Muscle lactate, ATP, and CP levels during exercise after physical training in man.

Karlsson, Jan; Nordesjö, Lars‐Olof; Jorfeldt, L.; Saltin, Bengt

doi:10.1152/jappl.1972.33.2.199

Cited by 165 publications

(67 citation statements)

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“…ATP contents of muscle obtained from conditioned athletes are higher (19). Of interest is the observation that the ATP and creatine phosphate depletion for a given amount of work appears to be less for conditioned muscle than for muscle from sedentary individuals (19). This latter observation may bear some resemblance to the finding that after prolonged incubation with aldosterone, the "glucose cost" of H+ transport was decreased.…”

Section: Resultsmentioning

confidence: 94%

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Effect of aldosterone on the coupling between H+ transport and glucose oxidation.

Al‐Awqati¹

1977

J. Clin. Invest.

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A B S T R A C T The mode of action of aldosterone on the energetics of H+ transport in the turtle bladder was examined with the rate of glucose oxidation as an index of the metabolic activity of the epithelium (we show that H+ transport is not coupled to fatty acid oxidation).Within 6 h of addition of aldosterone H+, transport increased; so did glucose oxidation. The amount of H+ transport per mole of 14CO2 produced from glucose oxidation was 15.6 eq mol-' in the control hemibladder, while in the aldosterone-treated bladder it was 13.6, A = 2.0+4.0 (n = 6). However, in bladders exposed to aldosterone for 20 h, the relation oftransport to glucose oxidation was significantly altered: control 10.8, aldosterone 16.4, A = 4.5+2.5, P < 0.02, ni = 7. The slope of H+ transport on the applied electrochemical gradient was steeper during both short-and long-term incubations. However, the maximum gradient necessary to nullify the net rate of secretion was unaltered in both experiments. Evidence is presented that aldosterone does not alter the passive backflux into the cell. In five additional experiments where aldosterone produced no significant stimulation of H+ transport, no change was noted in any of the metabolic or transport characteristics measured, suggesting that the alterations discussed above are dependent on the stimulation of H+ transport by the hormone.These results, along with some thermodynamic considerations, suggest that the effect of aldosterone is primarily exerted on the transport process rather than on metabolism. Further, it appears that prolonged stimulation of transport work leads to secondary alterations in the metabolic pathways reminiscent of the changes that occur in skeletal muscles of athletes undergoing physical conditioning.

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Section: Resultsmentioning

confidence: 94%

“…This kind of adaptation to increased work occurs in skeletal muscle. ATP contents of muscle obtained from conditioned athletes are higher (19). Of interest is the observation that the ATP and creatine phosphate depletion for a given amount of work appears to be less for conditioned muscle than for muscle from sedentary individuals (19).…”

Section: Resultsmentioning

confidence: 99%

Effect of aldosterone on the coupling between H+ transport and glucose oxidation.

Al‐Awqati¹

1977

J. Clin. Invest.

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“…Differences in level (Boning et al 1984), type (Stuart et al 1981) or duration (Nickleberry & Brooks, 1996) of training do not appear to have an effect on either gross or delta efficiency. Further, ýOµ is unchanged for a given moderate power output after training (Hagberg et al 1980), although during heavy exercise ýOµ may be reduced (Karlsson et al 1972), presumably due to a reduction in the slow component (Casaburi et al 1987). However, there is one brief report (Jammes et al 1997) which suggests enhanced motor unit recruitment in trained cyclists compared to untrained subjects, based on a greater increase in the root mean square (RMS) of the EMG of the vastus lateralis during incremental exercise.…”

Section: Discussionmentioning

confidence: 99%

Influence of Muscle Fibre Type and Fitness on the Oxygen Uptake/Power Output Slope During Incremental Exercise in Humans

Barstow

Jones

Nguyen

et al. 2000

Experimental Physiology

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We recently reported that a higher percentage of type I fibres in vastus lateralis and a greater peak oxygen uptake (V̇O2) were associated with a greater initial rise in V̇O2 (ΔV̇O2/ΔW, where W is work rate) following the onset of heavy constant power output exercise (above the lactate threshold, LT). It was unclear if these results were true only for heavy exercise, or if the association between fibre type and/or fitness and ΔV̇O2/ΔW would also be seen for moderate (< LT) exercise. The purpose of the present study was to compare the relationships between fibre type or peak V̇O2 and ΔV̇O2/ΔW determined for moderate (< LT) and heavy (> LT) exercise intensities during incremental exercise. Nine healthy subjects performed an incremental ramp test on a cycle ergometer. The V̇O2/Wslope was calculated for the domain of power outputs up to the LT (S1), from the LT towards peak V̇O2 (S2), and over the entire linear portion of the ΔV̇O2/ΔW response (ST), and compared to fibre type distribution determined from biopsy of the vastus lateralis, and to peak V̇O2 (as ml kg‐1 min‐1). Significant correlations between ΔV̇O2/ΔW and the proportion of type I fibres were found for each exercise domain (r is 0.69, 0.71 and 0.84 for S1, S2 and ST, respectively, P < 0.05). S1 ranged between about 9 ml min‐1 W‐1 for a low proportion of type I fibres and 11 ml min‐1 W‐1 for a high proportion of type I fibres. Similar correlations were also found between S2 (r = 0.70) and ST (r = 0.76) and peak V̇O2. These results are consistent with our previous findings during > LT constant power output exercise, and suggest that the proportion of type I fibres, and possibly fitness as indicated by peak V̇O2, is associated with greater ΔV̇O2/ΔW during the initial adjustment to < LT as well as > LT exercise. These results do not appear to be explained by classical descriptions of the kinetics of adjustment of V̇O2 following the onset of ramp or constant power output exercise. They might reflect enhanced motor unit recruitment in subjects with a greater percentage of type I fibres, and/or who are more aerobically fit. However, the underlying mechanism for these findings must await further study.

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“…The concentration of phosphocreatine and of ATP in muscles is lower the higher is the muscle metabolic rate at the steady state of an aerobic exercise Karlsson et al 1972;Molé et al 1985;Piiper et al 1968), as a consequence of the contraction of the oxygen deficit. The equilibrium constant of the Lohmann's reaction, however, is such that the equilibrium is displaced towards ATP resynthesis.…”

Section: Abbreviations and Symbolsmentioning

confidence: 99%

“…A comparison between the data of Ferretti et al (1987) as a function of steadystate oxygen consumption and the average ATP values obtained in the isolatedperfused dog muscle preparation (Piiper et al 1968) is reported in Fig. 6.7, in which b _ w and ATP concentration ([ATP]) are expressed relative to the respective resting Karlsson et al (1972) is also given on top of the figure. From Ferretti et al (1987) …”

Section: Abbreviations and Symbolsmentioning

confidence: 99%

Energetics of Muscular Exercise

Ferretti¹

2015

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Muscle lactate, ATP, and CP levels during exercise after physical training in man.

Cited by 165 publications

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Effect of aldosterone on the coupling between H+ transport and glucose oxidation.

Effect of aldosterone on the coupling between H+ transport and glucose oxidation.

Influence of Muscle Fibre Type and Fitness on the Oxygen Uptake/Power Output Slope During Incremental Exercise in Humans

Energetics of Muscular Exercise

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