Muscle mass has a greater impact on serum creatinine levels in older males than in females

Yim, Jisook; Son, Nak-Hoon; Kyong, Taeyoung; Park, Yongjung; Kim, Jeong-Ho

doi:10.1016/j.heliyon.2023.e21866

Cited by 4 publications

(1 citation statement)

References 26 publications

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“…A significant correlation between serum creatinine levels and skeletal muscle mass index was reported, while significant decline in muscle mass in older males as serum levels of creatinine increasing but sustain stable or even increasing in females [ 30 ]. The sharp decline in skeletal muscle mass among older male individuals is attributed to the decrease in testosterone levels and its anabolic effects [ 31 ], as well as the reduction in protein synthesis [ 32 ].…”

Section: Discussionmentioning

confidence: 99%

Skeletal muscle mass and kidney function among Chinese older adults: a cross-sectional study

Li,

Yang,

Wang

2024

Renal Failure

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Section: Discussionmentioning

confidence: 99%

Skeletal muscle mass and kidney function among Chinese older adults: a cross-sectional study

Li,

Yang,

Wang

2024

Renal Failure

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National trends of allergic diseases and pandemic–related factors among individuals with obesity in South Korea: A nationwide representative serial study, 2005–2021

Son,

Park,

Choi

et al. 2024

Heliyon

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Clinical Utility of LC-MS/MS for Blood Myo-Inositol in Patients with Acute Kidney Injury and Chronic Kidney Disease

Omosule,

Blair,

Herries

et al. 2024

Clinical Chemistry

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Background Diagnosing acute kidney injury (AKI) and chronic kidney disease (CKD) relies on creatinine, which lacks optimal diagnostic sensitivity. The kidney-specific proximal tubular enzyme myo-inositol oxygenase (MIOX) catalyzes the conversion of myo-inositol (MI) to D-glucuronic acid. We hypothesized that proximal tubular damage, which occurs in AKI and CKD, will decrease MIOX activity, causing MI accumulation. To explore this, we developed an LC-MS/MS assay to quantify plasma MI and assessed its potential in identifying AKI and CKD patients. Methods MI was quantified in plasma from 3 patient cohorts [normal kidney function (n = 105), CKD (n = 94), and AKI (n = 54)]. The correlations between MI and creatinine were determined using Deming regression and Pearson correlation and the impact of age, sex, and ethnicity on MI concentrations was assessed. Receiver operating characteristic curve analysis was employed to evaluate MI diagnostic performance. Results In volunteers with normal kidney function, the central 95th percentile range of plasma MI concentrations was 16.6 to 44.2 µM. Age, ethnicity, and sex showed minimal influence on MI. Patients with AKI and CKD exhibited higher median MI concentrations [71.1 (25th percentile: 38.2, 75th percentile: 115.4) and 102.4 (77, 139.5) µM], respectively. MI exhibited excellent sensitivity (98.9%) and specificity (100%) for diagnosing CKD. In patients with AKI, MI increased 32.9 (SD 16.8) h before creatinine. Conclusions This study unveils MI as a potential renal biomarker, notably elevated in plasma during AKI and CKD. Plasma MI rises 33 h prior to serum creatinine, enabling early AKI detection. Further validation and exploration of MI quantitation in kidney disease diagnosis is warranted.

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Muscle mass has a greater impact on serum creatinine levels in older males than in females

Cited by 4 publications

References 26 publications

Skeletal muscle mass and kidney function among Chinese older adults: a cross-sectional study

Skeletal muscle mass and kidney function among Chinese older adults: a cross-sectional study

National trends of allergic diseases and pandemic–related factors among individuals with obesity in South Korea: A nationwide representative serial study, 2005–2021

Clinical Utility of LC-MS/MS for Blood Myo-Inositol in Patients with Acute Kidney Injury and Chronic Kidney Disease

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