Muscle nerve sympathetic activity during sleep and its change with arousal response

Shimizu, Tetsuo; Takahashi, Yūji; Suzuki, Kazumasa; Kogawa, Susumu; Tashiro, Tetsuo; Takahasi, Kenichi; Hishikawa, Yasuo

doi:10.1111/j.1365-2869.1992.tb00035.x

Cited by 40 publications

(27 citation statements)

References 23 publications

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“…Increased muscle SNA and BP coincided with the phasic eye movements of REM sleep [10,51], while muscle SNA tended to decrease as REM sleep duration increased [51]. Auditory stimuli causing arousals during NREM sleep also gave rise to a transient increase in muscle SNA and BP [10,51]. It should be emphasized that muscle SNA, although physiologically important, is only part of total SNA.…”

Section: The Cardiovascular System In Normal Sleepmentioning

confidence: 91%

“…Recent studies in humans have shown that muscle SNA increased above the wakefulness level during tonic REM sleep [42,49], and fell whenever muscle tone increased (REM twitches), concomitant with an increase in BP [42]. Increased muscle SNA and BP coincided with the phasic eye movements of REM sleep [10,51], while muscle SNA tended to decrease as REM sleep duration increased [51]. Auditory stimuli causing arousals during NREM sleep also gave rise to a transient increase in muscle SNA and BP [10,51].…”

Section: The Cardiovascular System In Normal Sleepmentioning

confidence: 99%

“…Parasympathetic tone is high during sleep [8], but the sympathetic system is activated during apnoeas [9] and is likely to be involved in OSA-induced cardiocirculatory changes. Finally, most OSA end with an arousal, which increases sympathetic activity, blood pressure, and heart rate [10,11]. Therefore, OSA-induced acute circulatory changes should be considered as integrated responses to different pathogenic factors acting simultaneously or in rapid succession.…”

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confidence: 99%

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The cardiovascular effects of obstructive sleep apnoeas: analysis of pathogenic mechanisms

Mr¹,

Marrone²,

Insalaco³

et al. 1994

Eur Respir J

132

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Section: The Cardiovascular System In Normal Sleepmentioning

confidence: 91%

Section: The Cardiovascular System In Normal Sleepmentioning

confidence: 99%

mentioning

confidence: 99%

See 1 more Smart Citation

The cardiovascular effects of obstructive sleep apnoeas: analysis of pathogenic mechanisms

Mr¹,

Marrone²,

Insalaco³

et al. 1994

Eur Respir J

132

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“…The sympathetic activity during tonic REM sleep is much higher than that in wakefulness. As differentiated from REM sleep, NREM sleep is characterized by the prevalence of parasympathetic influences [17][18][19].…”

Section: Importance Of Monitoring Of Emotional Stress and Physiologicalmentioning

confidence: 99%

Importance of Monitoring of Emotional Stress and Physiological Functions of Humans during the Night Sleep

Yumatov¹,

Перцов²

2017

JPP

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Abstract:The diagnosis of disease and prescription of therapy are mainly realized through the control of physiological functions in humans during wakefulness. However, little attention is paid to evaluate the functional state of a patient in sleep. The efficiency of prescribed medicines is also determined in wakefulness. The effects of these drugs during sleep are usually out-of-sight of a physician. Human psychoemotional state during wakefulness is closely related to sleep. Various serious disturbances in physiological functions appear during the night sleep. They include cardiovascular disorders (hypertensive crisis, myocardial infarction, arrhythmias, stroke, etc.), which may cause sudden death. A large body of evidence shows that stress is followed by sleep disorders. They serve as a factor, which contributes to the development of stress. It should be noted that sleep is the major anti-stress factor. The vicious circle is formed, which can be revealed by a complex control of human physiological functions during wakefulness and sleep. We developed a new methodology and constructed an information-and-equipment device for monitoring of vital physiological functions of humans during sleep in a real everyday life. This approach holds much promise for the diagnosis of disease and evaluation of therapeutic efficacy.

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“…28 Arousal from sleep defends against asphyxia but elicits a further, centrallyinitiated increase in sympathetic nerve firing and withdrawal of vagal tone. 29 The oscillations in ventilation characteristic of CSA are accompanied by similar autonomic and chemical disturbances but by less variation in intrathoracic pressure. 30, 31 Hence stroke volume tends to rise subtly rather than fall with each central apnea or hypopnea.…”

Section: Observational Studiesmentioning

confidence: 99%

Sleep-Disordered Breathing in Heart Failure　― A Therapeutic Dilemma ―

Haruki

Floras

2017

Circ J

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for their deployment can be advocated (Table). However, the promise of observational studies and randomized trials of small size and duration describing a beneficial effect of treating SDB in HF via positive airway pressure (PAP) was not realized in 2 recent randomized outcome-driven trials: SAVE, which evaluated the cardiovascular effect of treating OSA in a cohort without HF, 7 and SERVE-HF, which reported the results of a strategy of random allocation of minute-ventilation-triggered adaptive servo-ventilation (ASV) for HF patients with CSA. 3 Consequently, equipoise remains as to whether either OSA or CSA, once detected in a HF patient with reduced left ventricular ejection fraction (LVEF), should be therapeutically suppressed. The threefold purpose of this review was to: (1) summarize current knowledge concerning the prevalence, pathophysiology, and prognostic implications of SDB in HF in support of treatment; (2) examine and reflect upon the results of randomized controlled trials evaluating the effect of treating OSA or CSA on cardiovascular endpoints and mortality; and (3) illustrate how ADVENT-HF, a randomized controlled trial designed to determine the effect of treating HF patients with either CSA or nonsleepy OSA using a peak-airflow triggered ASV algorithm, could resolve the present clinical equipoise concerning the treatment of one or both forms of SDB.A fundamental and as yet unresolved question for the heart failure (HF) community is whether coexisting obstructive (OSA) or central sleep apnea (CSA) should be specific targets of therapy. For individuals without HF, the principal clinical indication to treat sleep apnea is to improve quality of life (QOL) and avert accidental injury or death by alleviating daytime hypersomnolence. However, this indication does not pertain to the majority of patients with reduced left ventricular systolic function and sleep-disordered breathing (SDB) as they are not burdened by excess daytime sleepiness. 1-3 In such individuals, the impetus to diagnosis and treatment is the hypothesis that attenuation or abolition of SDB will modify beneficially the natural history of HF.OSA and CSA interrupt breathing by different mechanisms but impose qualitatively similar autonomic, chemical, mechanical, and inflammatory burdens on the heart and circulation. 4-6 Because contemporary evidence-based drug and device HF therapies have little or no mitigating effect on the acute consequences of such stimuli or on the long-term structural and functional adaptations they induce within the atria and ventricles, the brain and the peripheral vasculature, there is a sound mechanistic rationale for targeting SDB to reduce cardiovascular event rates and prolong life. Importantly, effective treatment is presently available for both OSA and CSA and cogent reasons Sleep-disordered breathing (SDB) occurs in approximately 50% of patients with reduced left ventricular ejection fraction receiving contemporary heart failure (HF) therapies. Obstructive (OSA) and central sleep apneas (CSA) interrupt brea...

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Muscle nerve sympathetic activity during sleep and its change with arousal response

Cited by 40 publications

References 23 publications

The cardiovascular effects of obstructive sleep apnoeas: analysis of pathogenic mechanisms

The cardiovascular effects of obstructive sleep apnoeas: analysis of pathogenic mechanisms

Importance of Monitoring of Emotional Stress and Physiological Functions of Humans during the Night Sleep

Sleep-Disordered Breathing in Heart Failure　― A Therapeutic Dilemma ―

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Muscle nerve sympathetic activity during sleep and its change with arousal response

Cited by 40 publications

References 23 publications

The cardiovascular effects of obstructive sleep apnoeas: analysis of pathogenic mechanisms

The cardiovascular effects of obstructive sleep apnoeas: analysis of pathogenic mechanisms

Importance of Monitoring of Emotional Stress and Physiological Functions of Humans during the Night Sleep

Sleep-Disordered Breathing in Heart Failure ― A Therapeutic Dilemma ―

Contact Info

Product

Resources

About

Sleep-Disordered Breathing in Heart Failure　― A Therapeutic Dilemma ―