Muscle Oxygenation of the Paretic and Nonparetic Legs During and After Arterial Occlusion in Chronic Stroke

Whyte, Elizabeth; Thomas, Scott; Marzolini, Susan

doi:10.1016/j.jstrokecerebrovasdis.2021.106265

Cited by 4 publications

(3 citation statements)

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“…The following data were calibrated from a 0% to 100% scale using the arterial occlusion results. Arterial occlusion results have been published elsewhere 44 . The desaturation slope during the second treadmill exercise was significantly steeper ( p = .047) in the paretic leg (−0.7 ± 0.6%/s) compared to the nonparetic leg (−0.3 ± 0.2%/s) (Table 3).…”

Section: Resultsmentioning

confidence: 70%

“…Arterial occlusion results have been published elsewhere. 44 The desaturation slope during the second treadmill exercise was significantly steeper (p = .047) in the paretic leg (À0.7 AE 0.6%/s) compared to the nonparetic leg (À0.3 AE 0.2%/s) (Table 3). A steeper desaturation slope was observed in the paretic leg in 80% (8/10) of the participants.…”

Section: Resultsmentioning

confidence: 95%

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Muscle oxygenation of the paretic and nonparetic legs during and after exercise in chronic stroke: Implications for mobility

Whyte

Thomas

Marzolini

2023

PM&R

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BackgroundOxygen delivery and demand are reduced in the paretic leg of individuals after stroke. However, it is unknown how muscle oxygenation, the balance between delivery and utilization of oxygen at the muscle, is altered post‐stroke during aerobic exercise and how it relates to mobility.ObjectiveTo monitor muscle oxygenation changes between the paretic and nonparetic legs of individuals after stroke during treadmill exercise and the 6‐minute walk test and analyze the association with mobility.DesignCross‐sectional study.SettingCardiac rehabilitation program.PatientsEleven male participants were enrolled in the study. Ten men (30.8 ± 4.1 months post‐stroke; age 63.9 ± 13.9 years) with hemiparetic gait pattern finished the study.Methods or interventionsNot applicable.Main outcome measuresMuscle oxygenation was measured with near‐infrared spectroscopy placed on the vastus lateralis of each leg during treadmill exercise at the first ventilatory threshold and during a 6‐minute walk test.ResultsThe desaturation slope during treadmill exercise was significantly steeper (p = .047) in the paretic (−0.7 ± 0.6%/s) compared to the nonparetic leg (−0.3 ± 0.2%/s). There was no other significant difference between legs. The 6‐minute walk test distance was not correlated with 6‐minute walk test muscle oxygenation in either leg (paretic: r = 0.20, p = 0.590; nonparetic: r = 0.42, p = .232).ConclusionsAt the onset of treadmill exercise, the paretic leg was unable to effectively match the oxygen demand and extraction of the nonparetic leg, suggesting the need for an immediate cardiovascular warmup prior to initiating moderate intensity exercise in this population. Because the exercise desaturation rate is thought to indicate increased anaerobic metabolism and lactate production, efforts to delay rapid desaturation could improve the sustainability of activities of daily living and exercise.

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Section: Resultsmentioning

confidence: 70%

Section: Resultsmentioning

confidence: 95%

Muscle oxygenation of the paretic and nonparetic legs during and after exercise in chronic stroke: Implications for mobility

Whyte

Thomas

Marzolini

2023

PM&R

Self Cite

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“…In particular, there are many examples where both the central and peripheral aerobic functions have to be monitored, such as in chronic heart failure (CHF) patients [ 157 ]. To better understand the impact of exercise training, pulmonary ventilation and cardiac output measurements should also be acquired by a computerized metabolic cart [ 158 ]. The assessment of the muscle-fiber recruitment patterns on muscle oxygen utilization is of interest to gain a comprehensive knowledge of the muscular activation patterns.…”

Section: Resultsmentioning

confidence: 99%

A Narrative Review on Multi-Domain Instrumental Approaches to Evaluate Neuromotor Function in Rehabilitation

Scano

Guanziroli²,

Brambilla

et al. 2023

Healthcare

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In clinical scenarios, the use of biomedical sensors, devices and multi-parameter assessments is fundamental to provide a comprehensive portrait of patients’ state, in order to adapt and personalize rehabilitation interventions and support clinical decision-making. However, there is a huge gap between the potential of the multidomain techniques available and the limited practical use that is made in the clinical scenario. This paper reviews the current state-of-the-art and provides insights into future directions of multi-domain instrumental approaches in the clinical assessment of patients involved in neuromotor rehabilitation. We also summarize the main achievements and challenges of using multi-domain approaches in the assessment of rehabilitation for various neurological disorders affecting motor functions. Our results showed that multi-domain approaches combine information and measurements from different tools and biological signals, such as kinematics, electromyography (EMG), electroencephalography (EEG), near-infrared spectroscopy (NIRS), and clinical scales, to provide a comprehensive and objective evaluation of patients’ state and recovery. This multi-domain approach permits the progress of research in clinical and rehabilitative practice and the understanding of the pathophysiological changes occurring during and after rehabilitation. We discuss the potential benefits and limitations of multi-domain approaches for clinical decision-making, personalized therapy, and prognosis. We conclude by highlighting the need for more standardized methods, validation studies, and the integration of multi-domain approaches in clinical practice and research.

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Identification of Ischemic Stroke Condition Based on Hemodynamic Biomarkers

2022

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Muscle Oxygenation of the Paretic and Nonparetic Legs During and After Arterial Occlusion in Chronic Stroke

Cited by 4 publications

References 42 publications

Muscle oxygenation of the paretic and nonparetic legs during and after exercise in chronic stroke: Implications for mobility

Muscle oxygenation of the paretic and nonparetic legs during and after exercise in chronic stroke: Implications for mobility

A Narrative Review on Multi-Domain Instrumental Approaches to Evaluate Neuromotor Function in Rehabilitation

Identification of Ischemic Stroke Condition Based on Hemodynamic Biomarkers

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