Muscle power after glucose-potassium loading in undernourished patients.

Chan, Siu‐Lung; McLaughlin, Steve; Ponting, G. A.; Biglin, J.; Dudley, H. A. F.

doi:10.1136/bmj.293.6554.1055

Cited by 32 publications

(14 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…However, we think it unlikely that changes in blood gases affected our results because no direct effect of acute hypoxia and hypercapnia/acidosis on MRR has been shown in humans [23]. Nevertheless, other metabolic influences of MRR on skeletal muscle, such as thyroid [24] and nutritional [25] status, were not controlled in our study.…”

Section: Discussionmentioning

confidence: 40%

Noninvasive Measurement of the Maximum Relaxation Rate of Inspiratory Muscles in Patients with Neuromuscular Disorders

García‐Río

Mediano²,

Pino³

et al. 2006

Respiration

View full text Add to dashboard Cite

Background: Slowing of inspiratory muscle relaxation has been used as an index for inspiratory muscle fatigue. However, maximum relaxation rate measured from oesophageal pressure traces after maximum sniff (P_oes MRR) has limited clinical usefulness because it requires an oesophageal balloon catheter system. Objectives: It was the aim of this study to establish whether, in neuromuscular patients, maximum relaxation rate assessed from sniff nasal pressure (P_nasal MRR) reflects oesophageal MRR and the tension-time index of the diaphragm (TT_di). Methods: Twenty patients with neuromuscular disease and 10 healthy subjects were studied. P_oes and transdiaphragmatic pressure were measured while P_nasal was recorded with a balloon advanced through the nose into the nasopharynx. Maximum P_oes, transdiaphragmatic pressure and P_nasal were simultaneously measured while the patients performed maximal sniffs. The MRR (% pressure fall/10 ms) for each sniff, the TT_di and the tension-time index of respiratory muscles were determined. Results: Neuromuscular patients showed higher TT_di, lower P_oes MRR and lower P_nasal MRR than the control group. In patients with neuromuscular disease, the correlation coefficient of P_nasal MRR and P_oes MRR was 0.985 (p < 0.001). Regression analysis showed that P_oes MRR = –1.101 + 1.113·P_nasal MRR (r² = 0.929, standard error of the estimate = 0.208). Indeed, P_nasal MRR was negatively correlated with TT_di (r = –0.914, p < 0.001) and the tension-time index of respiratory muscles (r = –0.732, p < 0.001). In the neuromuscular group, the mean difference between P_nasal MRR and P_oes MRR was 0.286 ± 0.217%/10 ms. Conclusions: P_nasal MRR obtained from a maximal sniff accurately reflects P_oes MRR and TT_di in patients with neuromuscular disorders.

show abstract

Section: Discussionmentioning

confidence: 40%

Noninvasive Measurement of the Maximum Relaxation Rate of Inspiratory Muscles in Patients with Neuromuscular Disorders

García‐Río

Mediano²,

Pino³

et al. 2006

Respiration

View full text Add to dashboard Cite

show abstract

“…We (19) and others (20) have also observed that fasted and hypocalorically fed rats and malnourished humans have a slower relaxation rate, perhaps, as shown herein, due to a fall in AGATP.…”

Section: Musclefree Mg2+mentioning

confidence: 82%

Effect of dietary manipulations (fasting, hypocaloric feeding, and subsequent refeeding) on rat muscle energetics as assessed by nuclear magnetic resonance spectroscopy.

Pichard¹,

Vaughan²,

Struk³

et al. 1988

J. Clin. Invest.

View full text Add to dashboard Cite

31p nuclear magnetic resonance (NMR) spectroscopy in vivo and fluorometry were used to measure muscle ATP, total creatine, pH, and Mg2+ in vivo; and to calculate creatine phosphate (CrP), the ratios-of CrP/inorganic phosphate (Pi), CrP/ ATP, free ADP levels, and the free-energy change in ATP hydrolysis so nutritional effects could be ascertained. These parameters were determined in vivo in resting control, 2-dfasted, and hypocalorically fed rats and in animals similarly hypocalorically fed and then refed. The ATP, Pi, and intracellular Mg2+ levels were comparable in the four groups. When the fasted and underfed animals were compared with the control and refed animals, there were falls in the ratios of CrP/Pj and CrP/ATP, in the calculated CrP, and the free-energy change of ATP hydrolysis, but a rise in the calculated free ADP. In the hypocaloric group, intracellular pH fell significantly and a large peak was noted in the phosphodiester region. The data are consistent with the hypothesis that ATP levels are maintained at the cost of CrP, suggesting that ATP production is disturbed by aerobic and anaerobic mechanisms.

show abstract

“…This suggests other physiologic factors are involved. The observations that muscle dysfunction begins within 24 h of fasting in humans [33] prior to a significant loss of nitrogen (and, therefore, muscle size), and that muscle function is normalized sooner than expected with refeeding [33][34][35][36][37] further supports the presence of other factors.…”

Section: Alteration In Muscle Size and Functionmentioning

confidence: 75%

“…Impairment of the swallow caused by a lack of available energy, therefore, should improve quickly with nutritional support. Chan et al [33] observed a return to normal muscle function parameters in malnourished surgical patients after 2 days of intravenous glucose and potassium administration. This quick response to energy substrate may explain the normal muscle function parameters observed by Shizgal et al [34] (see Table 2).…”

Section: Nutrition Supportmentioning

confidence: 97%

See 1 more Smart Citation

Can protein-calorie malnutrition cause dysphagia?

Veldee

Peth

1992

Dysphagia

View full text Add to dashboard Cite

Nutrient deprivation has previously been shown to cause alterations in muscle and nerve function. Although an effect has never been studied in the neuromusculature of deglutition, the authors argue that an effect is likely. The proposed result is an increase in swallowing impairment in dysphagic individuals and associated risk of aspiration. Research studying the relationship between malnutrition and dysphagia is needed to verify clinical significance. Until controlled studies are completed, the authors suggest alternative alimentation in repleting severely malnourished dysphagic patients prior to attempting oral diet. A review of nutritional status indices is included to aid in identifying dysphagic patients at nutritional risk. Early identification of nutritional compromise and intervention can prevent malnutrition and its deleterious effects.

show abstract

Muscle power after glucose-potassium loading in undernourished patients.

Cited by 32 publications

References 13 publications

Noninvasive Measurement of the Maximum Relaxation Rate of Inspiratory Muscles in Patients with Neuromuscular Disorders

Noninvasive Measurement of the Maximum Relaxation Rate of Inspiratory Muscles in Patients with Neuromuscular Disorders

Effect of dietary manipulations (fasting, hypocaloric feeding, and subsequent refeeding) on rat muscle energetics as assessed by nuclear magnetic resonance spectroscopy.

Can protein-calorie malnutrition cause dysphagia?

Contact Info

Product

Resources

About