Muscle Quality is More Impaired in Sarcopenic Patients With Chronic Obstructive Pulmonary Disease

Abstract

Type I muscle fiber proportion is lower in sarcopenic compared with nonsarcopenic patients with COPD. Longitudinal studies may elucidate if the loss of muscle oxidative phenotype drives or accelerates the process of muscle wasting.

Sarcopenia in COPD: a systematic review and meta-analysis

“…Additionally, we meta-analysed all the excluded studies that measured only the lean mass component of sarcopenia given that, prior to 2010, having a low lean mass was considered to represent sarcopenia (figure 1) [34,38,40]. These studies applied two main muscle indices: appendicular skeletal muscle mass index (ASMI), also referred as skeletal mass index (SMI) [9][10][11][12][13][14][15], and fat-free mass index (FFMI) [16][17][18][19][20][21][22][23][24][25][26][27][28][29]. The prevalence of low lean mass based on ASMI in COPD patients was 31.0% (95 CI 28.2%-34.2%, I 2 =65%, p<0.01).…”

Malnutrition and sarcopenia assessment in patients with chronic obstructive pulmonary disease according to international diagnostic criteria, and evaluation of raw BIA variables

“…Widely accepted diagnostic criteria for sarcopenia have been developed by the European Working Group of Sarcopenia in Older People (EWGSOP), who have proposed an algorithm based on loss of skeletal muscle mass (SM) plus reduced strength and/or performance [4,9]. However, only few studies evaluating sarcopenia in COPD have so far considered muscle mass plus strength and performance [10,11], and other papers have just focused on the loss of muscle mass [12][13][14][15][16][17][18][19][20]. Finally, it is also worth underlining that no study has evaluated the simultaneous presence of sarcopenia and malnutrition in COPD (as assessed by ESPEN and EWGSOP criteria).…”

Increased Myogenic and Protein Turnover Signaling in Skeletal Muscle of Chronic Obstructive Pulmonary Disease Patients With Sarcopenia

“…1 Apart from an age-associated decline in muscle mass, sarcopenia also encompasses the loss of muscle mass due to diseases such as chronic obstructive pulmonary disease (COPD). 2 In COPD patients, sarcopenia is a frequently observed comorbidity, affecting exercise capacity, 3,4 quality of life, 3 and survival. 5e7 Although muscle mass maintenance is considered to be primarily dictated by the balance between protein degradation and protein synthesis rates (ie, protein turnover), their relative contribution to imbalanced protein turnover during muscle mass loss remains unclear.…”