Muscle Regeneration and Fiber-Type Transformation during Distraction Osteogenesis

Deyne, Patrick G. De; Hayatsu, Kazunori; Meyer, Rick; Paley, Dror; Herzenberg, John E.

doi:10.2106/00004623-200009000-00043

Cited by 11 publications

(17 citation statements)

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“…We do not recommend increasing the rate of distraction because lengthening is not a matter of bone alone. Although a faster distraction can make a faster removal of the external fixator, it results in greater burden to the surrounding muscles, consequently leaving more fibrosis or degeneration [12,35,49,51].…”

Section: Discussionmentioning

confidence: 99%

Bone Marrow Aspirate Concentrate and Platelet-rich Plasma Enhanced Bone Healing in Distraction Osteogenesis of the Tibia

Lee¹,

Ryu²,

Kim³

et al. 2014

Clin Orthop Relat Res

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Background During lower limb lengthening, poor bone regeneration is a devastating complication. Several local or systemic applications have been used to promote osteogenesis, and biologic stimulations are gaining attention, but their utility has not been proven in this setting. Questions/purposes In patients undergoing bilateral tibial lengthening, we compared those receiving an osteotomy site injection of autologous bone marrow aspirate concentrate (BMAC) plus platelet-rich plasma (PRP) with those not receiving such an injection in terms of external fixator index (time in external fixation divided by amount of lengthening), full weightbearing index (time until a patient was permitted to do full weightbearing divided by amount of lengthening), four cortical healing indexes (time until each cortical union divided by amount of lengthening), and callus shape and type. Methods Twenty-two patients (44 tibias) undergoing bilateral tibial lengthening enrolled in this randomized trial. Two patients were excluded, one due to insufficient radiographic evaluation and one who was lost to followup, leaving 20 patients (40 segments) for inclusion. Ten patients (20 segments) received BMAC combined with PRP injection (treatment group) and 10 patients (20 segments) received no injection (control group). All patients underwent stature lengthening for familial short stature with the lengthening over nail technique. Autologous BMAC combined with PRP was injected at the tibial osteotomy site at the end of the index surgery. Mean distraction rates were similar between groups (0.75 mm/day in the treatment group versus 0.72 mm/day in the control group; p = 0.24). Full weightbearing was permitted when we observed radiographic evidence of healing at two cortices; this assessment was made by the surgeon who was blinded to the treatment each patient received. Minimum followup was 24 months (mean, 28 months; range, 24-34 months).

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Section: Discussionmentioning

confidence: 99%

Bone Marrow Aspirate Concentrate and Platelet-rich Plasma Enhanced Bone Healing in Distraction Osteogenesis of the Tibia

Lee¹,

Ryu²,

Kim³

et al. 2014

Clin Orthop Relat Res

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“…Однако при этом требуется соот-ветствующее увеличение силы мышц бедра и голени. Важно заранее просчитать, не повлияет ли получаемый эстетический эффект от изменения пропорций тела на функциональную составляющую -скорость локомоций и проходимый за сутки путь [2,5].…”

Section: нарушение продольного роста конечности и сократительная спосunclassified

Disorder of the Longitudinal Limb Growth and Muscular Contractility

2015

Annals RAMS

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У здоровых детей продольный рост конечностей со-провождается адекватным увеличением объема мышц и их сократительной способности. У высокорослых де-тей сила мышц конечностей, отнесенная к массе тела, сравнительно больше. Положительная зависимость силы мышц от продольных размеров тела сохраняется у юно-шей вплоть до достижения длины тела 185 см. Такая взаимосвязь позволяет рассматривать прирост динамоме-трических показателей мышц, связанный с увеличением продольных размеров тела как положительное явление [1]. Данное положение подтверждается при анализе спор-тивных достижений атлетов и является одним из положи-тельных следствий акселерации роста тела [1].Продольный рост и увеличение силы идут не совсем синхронно. Известно, что рост и развитие -чередующи-еся по времени события, что обнаруживается в период пу-бертатного ускорения роста. Более того, при оперативном удлинении конечности, когда темп дистракции в 30 раз выше скорости естественного роста, наблюдается не уве-личение, а падение сократительной способности мышц, на последующее восстановление показателей которой требуются месяцы и годы [2]. V.A. Schurov

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“…Investigators have reported that distraction osteogenesis promotes muscle regeneration, including increased sarcomerogenesis, higher numbers of proliferating nuclei, and increased muscle weight. [8][9][10][11][12] In addition, Olfert et al 23 showed that VEGF produced by myocytes was required for regulating muscle capillarity. These results suggest that VEGF in the satellite cells, induced by mechanical tension-stress, also affect myogenesis and angiogenesis.…”

Section: Angiogenesis and Myogenesis In Lengthened Skeletal Musclesmentioning

confidence: 99%

“…[4][5][6][7] Similar results have been reported for myogenesis in the surrounding skeletal muscles following distraction osteogenesis. [8][9][10][11][12] However, the cellular and molecular mechanisms underlying angiogenesis and myogenesis in the skeletal muscles which are induced by mechanical tension-stress during distraction osteogenesis has not yet been elucidated.…”

mentioning

confidence: 99%

Angiogenesis and myogenesis in mouse tibialis anterior muscles during distraction osteogenesis: VEGF, its receptors, and myogenin genes expression

Nishisho

Yukata

Matsui

et al. 2012

Journal Orthopaedic Research

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Angiogenesis and myogenesis occur in the surrounding skeletal muscles following distraction osteogenesis, but their molecular mechanisms remain unclear. The present study investigated morphological features of lengthened muscles and the time course change of vascular endothelial growth factor (VEGF), its receptors (VEGFR-1 and VEGFR-2) and myogenin gene expression profiles related to angiogenesis and myogenesis in tibialis anterior (TA) muscles with a mouse model of distraction osteogenesis, which involves 1 week of waiting period (latency phase), 2 weeks of intermittent distraction (distraction phase), and 5 weeks of remodeling period (consolidation phase). Macroscopic findings showed that lengthened TA muscles increased to approximately 42% longer and 10% heavier at the end of the process when compared to pre-surgery. During the distraction phase, VEGF and its receptors were induced in the vascular endothelial cells, myogenin-positive satellite cells and myocytes, and subsequently, capillary progression and myogenesis were increased. Real-time RT-PCR showed that Vegf, Vegfr-1, Vegfr-2, and myogenin genes expression was enhanced during the muscle lengthening. Vegf and Vegfr-1 were upregulated following the recession of angiogenesis at the consolidation phase. We conclude that upregulation of VEGF and its receptors by mechanical tension-stress could be involved in the process of angiogenesis and myogenesis in lengthened muscles. ß

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Muscle Regeneration and Fiber-Type Transformation during Distraction Osteogenesis

Cited by 11 publications

References 0 publications

Bone Marrow Aspirate Concentrate and Platelet-rich Plasma Enhanced Bone Healing in Distraction Osteogenesis of the Tibia

Bone Marrow Aspirate Concentrate and Platelet-rich Plasma Enhanced Bone Healing in Distraction Osteogenesis of the Tibia

Disorder of the Longitudinal Limb Growth and Muscular Contractility

Angiogenesis and myogenesis in mouse tibialis anterior muscles during distraction osteogenesis: VEGF, its receptors, and myogenin genes expression

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