Muscle reinnervation—I. Restoration of transmitter release mechanisms

Carmignoto, Giorgio; Finesso, M.; Siliprandi, Renata; Gorio, A.

doi:10.1016/0306-4522(83)90187-2

Cited by 49 publications

(25 citation statements)

References 24 publications

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“…On the denervated groups, the functional behavior followed the evidence already mentioned by Carmignoto et al 1 and Gorio et al 2 , where complete function loss was observed between the 7 th and the 14 th day, and recovery at the 21 st PO day, when the muscle is almost completely re-innervated.…”

Section: Discussionsupporting

confidence: 75%

“…After crush injuries, regeneration occurs spontaneously. In rats, no axons are found in the muscle ten days after injury because the muscle reinnervation begins two weeks after the injury 1,2 . Poly-innervation is observed two days after the neuritis reach the muscle, given that fifteen days after nerve crush 25% of muscle fibers are poly-innervated.…”

Section: Introductionmentioning

confidence: 99%

“…The process that eliminates excessive synaptic contacts starts at this time and, around the 60 th day, muscle fibers become mono-innervated. The remaining nerve terminals are increased in size and after 90 days the postsynaptic cleft is almost completely occupied 1 . However, at the end of the regeneration morphological alterations on regenerated axons remain.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

High-voltage electrical stimulation improves nerve regeneration after sciatic crush injury

Teodori

Silva

et al. 2011

Rev. bras. fisioter.

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Section: Discussionsupporting

confidence: 75%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

High-voltage electrical stimulation improves nerve regeneration after sciatic crush injury

Teodori

Silva

et al. 2011

Rev. bras. fisioter.

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“…An unknown cellular or molecular change which occurs during maturation from youth to adulthood seems to be responsible for a gradual decrease in transmitter release. 5,25,26 Bupivacaine injection into skeletal muscle causes rapid deterioration of the sarcolemma, destruction of the neuromuscular junction, and retraction of ter- Because tetanic tension in contralateral control or regenerating muscles did not differ among recovery days 14, 21, and 28, they have been pooled. *Denotes statistical significant difference (p < 0.05) from maximal tetanic tension recorded at 150 Hz.…”

Section: Discussionmentioning

confidence: 99%

The force-frequency relationship is altered in regenerating and senescent rat skeletal muscle

Marsh¹,

Hinds²,

Lester³

et al. 1998

Muscle Nerve

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“…Firstly, the fibres might have been reinnervated only in their proximal region making impossible the recording of synaptic activity from the distal third of the muscle, where the micro-electrode was routinely placed. Secondly, the fibres might have been recently reinnervated and their nerve terminals were not yet producing m.e.p.p.s (Carmignoto, Finesso, Siliprandi & Gorio, 1983). Finally, the fibres might not have been reinnervated but the presence of nerves in surrounding fibres somehow influenced the properties of the fibres.…”

Section: Denervation Of Rat Tonic Fibresmentioning

confidence: 99%

Induction of action potentials by denervation of tonic fibres in rat extraocular muscles.

Bondi¹,

Chiarandini²,

Jacoby³

1986

The Journal of Physiology

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The effects of denervation by nerve section on the electrical properties of tonic and twitch fibres of rat extraocular muscles were examined. Normally innervated tonic fibres lack action potentials. Upon direct stimulation they generate graded, voltage‐dependent responses or slow peak potentials (s.p.p.s). However, one week after denervation the s.p.p.s are transformed into action potentials which are slower and broader than those of twitch fibres. The action potentials are Na dependent and partially resistant to blockade with 10(‐5) M‐tetrodotoxin and 10(‐6) M‐saxitoxin. Changing the holding potential of the fibres from ‐80 mV to more negative levels increases the maximal rate of rise of the action potential. This effect is not observed on the s.p.p.s of normally innervated fibres. Following denervation the resting potential of tonic and twitch fibres becomes about 10‐15 mV less negative. In denervated muscles stimulation with pulses of hyperpolarizing current evokes graded responses in tonic fibres and action potentials in twitch fibres. In normally innervated muscles, these anodal break responses are never observed in tonic fibres and are very rare in twitch fibres. By two weeks after nerve section, reinnervation is present. The action potentials of tonic fibres are still present but stronger stimulation is needed to evoke anodal break responses. By three weeks, direct stimulation of tonic fibres evokes normal s.p.p.s in about 25% of the studied fibres and action potentials in the rest. By four weeks, most tonic fibres have lost the action potential but small anodal break responses can be evoked in most. It is suggested that following denervation a new population of Na channels appears in tonic fibres. The properties of these channels are different from those of the channels normally present in innervated tonic fibres but they are in some ways similar to those of the channels which appear in twitch fibres following denervation.

show abstract

Muscle reinnervation—I. Restoration of transmitter release mechanisms

Cited by 49 publications

References 24 publications

High-voltage electrical stimulation improves nerve regeneration after sciatic crush injury

High-voltage electrical stimulation improves nerve regeneration after sciatic crush injury

The force-frequency relationship is altered in regenerating and senescent rat skeletal muscle

Induction of action potentials by denervation of tonic fibres in rat extraocular muscles.

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