Muscle satellite cell content and mRNA signaling in germ cell cancer patients – effects of chemotherapy and resistance training

Christensen, Jan; Schjerling, Peter; Andersen, Jesper L.; Daugaard, Gedske; Rørth, Mikael; Mackey, Abigail L.

doi:10.3109/0284186x.2016.1170200

Cited by 9 publications

(8 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The changes in SC count were significantly associated with changes in muscle CSA and with muscle strength, indicating that the increase in Pax7-positive cells in the RT-HIIT group reflects an activation of skeletal muscle regeneration processes. The increase in SC count in our study is in contrast to findings from an RT intervention that included patients with prostate cancer receiving androgen deprivation therapy (19) and from a trial that included patients with germ cell cancer receiving cisplatin-based chemotherapy (20). Furthermore, in a trial by Christensen et al (21), no improvements in muscle CSA after a 9 wk RT intervention were shown.…”

Section: Discussioncontrasting

confidence: 90%

“…Despite the increasing number of studies showing the ability of exercise training to improve or maintain muscle strength and cardiorespiratory fitness in patients with cancer during chemotherapy (15), only 2 randomized, controlled exercise trials including resistance training (RT) for patients with prostate (19) and germ cell cancer (20,21) have investigated the molecular adaptations expected to occur with exercise training. Molecular musculoskeletal responses, including mitochondrial markers to exercise training in patients with breast cancer and adaptations to different exercise modalities during chemotherapy, have not been studied.…”

mentioning

confidence: 99%

See 1 more Smart Citation

Exercise training during chemotherapy preserves skeletal muscle fiber area, capillarization, and mitochondrial content in patients with breast cancer

et al. 2018

View full text Add to dashboard Cite

Exercise has been suggested to ameliorate the detrimental effects of chemotherapy on skeletal muscle. The aim of this study was to compare the effects of different exercise regimens with usual care on skeletal muscle morphology and mitochondrial markers in patients being treated with chemotherapy for breast cancer. Specifically, we compared moderate-intensity aerobic training combined with high-intensity interval training (AT-HIIT) and resistance training combined with high-intensity interval training (RT-HIIT) with usual care (UC). Resting skeletal muscle biopsies were obtained pre- and postintervention from 23 randomly selected women from the OptiTrain breast cancer trial who underwent RT-HIIT, AT-HIIT, or UC for 16 wk. Over the intervention, citrate synthase activity, muscle fiber cross-sectional area, capillaries per fiber, and myosin heavy chain isoform type I were reduced in UC, whereas RT-HIIT and AT-HIIT were able to counteract these declines. AT-HIIT promoted up-regulation of the electron transport chain protein levels vs. UC. RT-HIIT favored satellite cell count vs. UC and AT-HIIT. There was a significant association between change in citrate synthase activity and self-reported fatigue. AT-HIIT and RT-HIIT maintained or improved markers of skeletal muscle function compared with the declines found in the UC group, indicating a sustained trainability in addition to the preservation of skeletal muscle structural and metabolic characteristics during chemotherapy. These findings highlight the importance of supervised exercise programs for patients with breast cancer during chemotherapy.-Mijwel, S., Cardinale, D. A., Norrbom, J., Chapman, M., Ivarsson, N., Wengström, Y., Sundberg, C. J., Rundqvist, H. Exercise training during chemotherapy preserves skeletal muscle fiber area, capillarization, and mitochondrial content in patients with breast cancer.

show abstract

Section: Discussioncontrasting

confidence: 90%

mentioning

confidence: 99%

Exercise training during chemotherapy preserves skeletal muscle fiber area, capillarization, and mitochondrial content in patients with breast cancer

et al. 2018

View full text Add to dashboard Cite

show abstract

“…Few studies have investigated the molecular adaptations in muscle to exercise training in cancer patients, but those who have, show that functional adaptations are poorly reflected by molecular adaptations. For example, patients with germ cell cancer undergoing standard chemotherapy showed physiological adaptations to high-intensity resistance training, but no increase in the number of satellite cells, and no shift in fiber type composition or hypertrophy, which was observed in the healthy age-matched control group [28].…”

Section: Molecular Response In Muscle Tissuementioning

confidence: 94%

Exercise-mediated improvement of depression in patients with gastro-esophageal junction cancer is linked to kynurenine metabolism

et al. 2019

View full text Add to dashboard Cite

Background: Exercise may improve depression in cancer patients, yet the molecular mechanism behind this protection is poorly understood. Here, we aimed to explore the link between exercise and regulation of kynurenine (Kyn) metabolism and inflammation in patients with operable gastro-esophageal junction (GEJ) cancer patients, who improved significantly in depression score with exercise training. Material and Methods: Fifty GEJ cancer patients were allocated to 12 weeks of supervised training twice weekly including interval-based aerobic exercise and resistance training, or standard care. Depression score was evaluated by HADS, and blood samples and muscle biopsies were collected for determination of Kyn metabolism and inflammation across the intervention. Results: Depression scores decreased by À1.3 points in the exercise group (p < 0.01), whereas no changes were observed in the control group. Plasma 3-hydroxykynurenine (HK), a Kyn metabolite giving rise to other neurotoxic metabolites, increased by 48% (p <0.001) in the control group, while exercise training attenuated this accumulation. The production of HK is induced by inflammation, and while we observed no differences in systemic pro-inflammatory cytokines, exercise training ameliorated the treatment-induced intramuscular inflammation. Moreover, exercise has been suggested to convert Kyn to the neuroprotective metabolite, kynurenic acid (KA), but despite marked functional and muscular exercise-mediated adaptations, we did not observe any enhancement of KA production and related enzyme expression in the muscles of GEJ cancer patients. Conclusion: Exercise training reduced symptoms of depression in patients with GEJ cancer, and this effect was associated with an exercise-dependent attenuation of the inflammation-induced conversion of Kyn to neurotoxic metabolites.

show abstract

“…38 The number of Pax7+ cells/fibre in our patients was roughly comparable to reports of weight-losing cancer patients, 38 and we observed a trend towards more Pax7+ cells/fibre compared with HC but no change in patients over time. The trend towards greater Pax7+ cells in patients is unlikely related to treatment, as prior studies show no increase in Pax7+ cells in patients with testicular cancer treated with similar chemotherapy agents used in the current study (cisplatin 8,39 ) but could result from exposure to cigarette smoke, which exacerbates muscle injury. 40 Similarly, no change over time in patients or differences between patients and HC were noted in markers of DNA damage.…”

Section: Mediators Of Muscle Fibre Atrophymentioning

confidence: 41%

Skeletal muscle adaptations in patients with lung cancer: Longitudinal observations from the whole body to cellular level

Snoke,

Bellefleur,

Rehman

et al. 2023

J cachexia sarcopenia muscle

View full text Add to dashboard Cite

BackgroundCancer and its treatment can adversely affect skeletal muscle, impacting physical function, treatment response and survival. No studies, however, have comprehensively characterized these muscle adaptations longitudinally in human patients at the cellular level.MethodsWe examined skeletal muscle size and function from the whole body to the sub‐cellular level in 11 patients with non‐small cell lung cancer (NSCLC; 6 male/5 female, mean age 58 ± 3 years) studied over a 2‐month observation period starting during their first cycle of standard of care cancer treatment and in 11 age‐ and sex‐matched healthy controls (HC) without a current or past history of cancer. Biopsies of the vastus lateralis were performed to assess muscle fibre size, contractility and mitochondrial content, along with assessments of physical function, whole muscle size and function, and circulating cytokines.ResultsBody weight, composition and thigh muscle area and density were unaltered over time in patients with NSCLC, while muscle density was lower in patients with NSCLC versus HC (P = 0.03). Skeletal muscle fibre size decreased by 18% over time in patients (all P = 0.02) and was lower than HC (P = 0.02). Mitochondrial fractional area and density did not change over time in patients, but fractional area was lower in patients with NSCLC compared with HC (subsarcolemmal, P = 0.04; intermyofibrillar, P = 0.03). Patients with NSCLC had higher plasma concentrations of IL‐6 (HC 1.40 ± 0.50; NSCLC 4.71 ± 4.22; P < 0.01), GDF‐15 (HC 569 ± 166; NSCLC 2071 ± 1168; P < 0.01) and IL‐8/CXCL8 (HC 4.9 ± 1.8; NSCLC 10.1 ± 6.0; P = 0.02) compared with HC, but there were no changes in inflammatory markers in patients with NSCLC over time. No changes were observed in markers of satellite cell activation or DNA damage in patients and no group differences were noted with HC. Whole‐muscle strength was preserved over time in patients with NSCLC coincident with improved single fibre contractility.ConclusionsThis study is the first to comprehensively examine longitudinal alterations in skeletal muscle fibre size and function in patients with NSCLC and suggests that muscle fibre atrophy occurs during cancer treatment despite weight stability and no changes in conventional clinical measurements of whole body or thigh muscle size over this period.

show abstract

Muscle satellite cell content and mRNA signaling in germ cell cancer patients – effects of chemotherapy and resistance training

Cited by 9 publications

References 14 publications

Exercise training during chemotherapy preserves skeletal muscle fiber area, capillarization, and mitochondrial content in patients with breast cancer

Exercise training during chemotherapy preserves skeletal muscle fiber area, capillarization, and mitochondrial content in patients with breast cancer

Exercise-mediated improvement of depression in patients with gastro-esophageal junction cancer is linked to kynurenine metabolism

Skeletal muscle adaptations in patients with lung cancer: Longitudinal observations from the whole body to cellular level

Contact Info

Product

Resources

About