Muscle strength mediates the relationship between mitochondrial energetics and walking performance

Zane, Ariel C.; Reiter, David A.; Shardell, Michelle; Cameron, Donnie; Simonsick, Eleanor M.; Fishbein, Kenneth W.; Studenski, Stephanie A.; Spencer, Richard G.; Ferrucci, Luigi

doi:10.1111/acel.12568

Cited by 110 publications

(98 citation statements)

References 42 publications

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“…In accordance with this hypothesis, we have recently shown that muscle mitochondrial capacity is a strong independent correlate of lower extremity performance, especially in tasks that require walking at fast speeds or for long distances, and that long‐term exposure to some adiposity‐related factors may adversely affect mitochondrial function in humans . We have also found that muscle strength significantly mediates the relationship of mitochondrial function with walking performance . Overall, these results indicate that oxidative phosphorylation is progressively impaired with ageing; it is unclear whether this is because the number of mitochondria per muscle volume is diminished, the intrinsic capacity of mitochondria to generate ATP is impaired, or the availability of oxygen and nutrients at different levels of effort is compromised.…”

Section: Mitochondrial Oxidative Capacity and Metabolic Flexibilitysupporting

confidence: 57%

“…Multiple distinct and pre‐packaged adaptive strategies and signalling pathways in muscle allow boosting of energy production when demand increases, such as during prolonged exercise . For example, studies in human and animal models have revealed that the ability for the mitochondrial electron transport system to respond to increased demand declines with ageing, and this may account for some of the observed decrease in fitness in older persons .…”

Section: Mitochondrial Oxidative Capacity and Metabolic Flexibilitymentioning

confidence: 99%

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Searching for a mitochondrial root to the decline in muscle function with ageing

González-Freire

Adelnia

Moaddel

et al. 2018

J cachexia sarcopenia muscle

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Sarcopenia, the age‐related loss of muscle mass and strength, is linked to a range of adverse outcomes, such as impaired physical performance, cognitive function, and mortality. Preventing sarcopenia may reduce the burden of functional decline with aging and its impact on physiological and economic well‐being in older adults. Mitochondria in muscle cells lose their intrinsic efficiency and capacity to produce energy during aging, and it has been hypothesized that such a decline is the main driver of sarcopenia. Oxidative phosphorylation becomes impaired with aging, affecting muscle performance, and contributing to an age‐associated decline in mobility. However, it is unclear whether this deterioration is due to a reduced mitochondria population, decreased mitochondrial energetic efficiency, or a reduced capacity to dynamically transport oxygen and nutrients into the mitochondria, and addressing these questions is an active area of research. Further research in humans will require use of new “omics” technologies, progress in neuroimaging techniques that permit energy production assessment, and visualization of molecules critical for energetic metabolism, as well as proxy biomarkers of muscle perfusion.

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Section: Mitochondrial Oxidative Capacity and Metabolic Flexibilitysupporting

confidence: 57%

Section: Mitochondrial Oxidative Capacity and Metabolic Flexibilitymentioning

confidence: 99%

Searching for a mitochondrial root to the decline in muscle function with ageing

González-Freire

Adelnia

Moaddel

et al. 2018

J cachexia sarcopenia muscle

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“…While this is expected, it raises questions about the clinical relevance of these findings. We have previously reported, using data from this cohort, that k PCR was strongly associated with 400‐meter walking speed,30 which suggests that even such variations in this normal range might underlie subclinical alterations in function. We are in the process of collecting longitudinal data of ABI, mitochondrial function, and walking endurance from a larger sample, which will allow further elaboration on these findings.…”

Section: Discussionmentioning

confidence: 80%

“…We have previously reported, using data from the same cohort, that reduced mitochondrial energy production was associated with less exercise endurance, assessed by 400‐meter walking speed 30. Future studies are needed to demonstrate whether modest reduction of ABI when associated with impaired mitochondrial function predicts the risk of developing overt PAD.…”

Section: Discussionmentioning

confidence: 95%

Lower Mitochondrial Energy Production of the Thigh Muscles in Patients With Low‐Normal Ankle‐Brachial Index

AlGhatrif

Zane

Oberdier

et al. 2017

JAHA

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BackgroundLower muscle mitochondrial energy production may contribute to impaired walking endurance in patients with peripheral arterial disease. A borderline ankle‐brachial index (ABI) of 0.91 to 1.10 is associated with poorer walking endurance compared with higher ABI. We hypothesized that in the absence of peripheral arterial disease, lower ABI is associated with lower mitochondrial energy production.Methods and ResultsWe examined 363 men and women participating in the Baltimore Longitudinal Study of Aging with an ABI between 0.90 and 1.40. Muscle mitochondrial energy production was assessed by post‐exercise phosphocreatine recovery rate constant (kPCr) measured by phosphorus magnetic resonance spectroscopy of the left thigh. A lower post‐exercise phosphocreatine recovery rate constant reflects decreased mitochondria energy production.The mean age of the participants was 71±12 years. A total of 18.4% had diabetes mellitus and 4% were current and 40% were former smokers. Compared with participants with an ABI of 1.11 to 1.40, those with an ABI of 0.90 to 1.10 had significantly lower post‐exercise phosphocreatine recovery rate constant (19.3 versus 20.8 ms−1, P=0.015). This difference remained significant after adjusting for age, sex, race, smoking status, diabetes mellitus, body mass index, and cholesterol levels (P=0.028). Similarly, post‐exercise phosphocreatine recovery rate constant was linearly associated with ABI as a continuous variable, both in the ABI ranges of 0.90 to 1.40 (standardized coefficient=0.15, P=0.003) and 1.1 to 1.4 (standardized coefficient=0.12, P=0.0405).ConclusionsAn ABI of 0.90 to 1.10 is associated with lower mitochondrial energy production compared with an ABI of 1.11 to 1.40. These data demonstrate adverse associations of lower ABI values with impaired mitochondrial activity even within the range of a clinically accepted definition of a normal ABI. Further study is needed to determine whether interventions in persons with ABIs of 0.90 to 1.10 can prevent subsequent functional decline.

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“…Therefore, it is reported that the step -up training is advantageous for increasing the strength of the knee extensor muscles (Kim, 2015). In addition, increased knee extensor muscular strength is closely related to the improvement of walking speed (Zane et al, 2017).…”

Section: ⅳ Discussionmentioning

confidence: 99%

Effects of Step-up Training on Walking Ability of Stroke Patients by Different Support Surface Characteristics

Choi

Bang

et al. 2017

KSPM

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| Abstract |1 )PURPOSE: Gait disturbances in patients with hemiplegic stroke involve asymmetry of stance time.Step box training is used to supplement the limitations of stair walking training and increasing the torque value of the paralyzed lower leg's strength. This study aimed to investigate whether step-up training on unstable support could change walking ability in patients with chronic stroke. METHODS:Thirty stroke patients were randomly assigned to the step-up training group (experimental group), that performed training on an unstable surface, and the control group, that performed training on a stable surface. Walking speed, step length, and cadence were measured before and after training. Paired t-tests were used to compare pre-and post-intervention data, while the independent samples t-test was used to determine intergroup differences. Values of p < .05 were considered statistically significant. † Corresponding Author : cha0874@dju.kr This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. RESULTS:There was a significant difference in walking ability before versus after the intervention in both groups, although the experimental group showed greater differences than the control group (walking velocity by 8.1%; step length of the non-paralyzed side by 6.9%, respectively; p<.05). CONCLUSION:Step-up training might be more effective on an unstable surface than on a stable surface for increasing walking speed and step length of the non-paralyzed side.

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Muscle strength mediates the relationship between mitochondrial energetics and walking performance

Cited by 110 publications

References 42 publications

Searching for a mitochondrial root to the decline in muscle function with ageing

Searching for a mitochondrial root to the decline in muscle function with ageing

Lower Mitochondrial Energy Production of the Thigh Muscles in Patients With Low‐Normal Ankle‐Brachial Index

Effects of Step-up Training on Walking Ability of Stroke Patients by Different Support Surface Characteristics

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