Muscle sympathetic nervous activity in depressed patients before and after treatment with sertraline

Scalco, Andréia Zavaloni; Rondon, Maria Urbana Pinto Brandão; Trombetta, Ivani C.; Laterza, Mateus Camaroti; Azul, J B C C Serro; Pullenayegum, Eleanor; Scalco, Mônica Zavaloni; Kuniyoshi, Fatima H. Sert; Wajngarten, Maurı́cio; Negräo, Carlos Eduardo; Lotufo-Neto, Francisco

doi:10.1097/hjh.0b013e3283310ece

Cited by 59 publications

(43 citation statements)

References 59 publications

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“…Anti-depressants, in particular, have been shown to dramatically inhibit central sympathetic outflow and reduce MSNA (Esler et al, 1991; Scalco et al, 2009). The reduction in MSNA, while not statistically significant, appeared to be even greater with the combination of MS disease modifying therapy and these medications compared to disease modifying therapy alone (Figure 3).…”

Section: Discussionmentioning

confidence: 99%

Reduced spontaneous sympathetic nerve activity in multiple sclerosis patients

Keller

Fadel

Harnsberger

et al. 2014

Journal of the Neurological Sciences

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For the first time, we obtained direct intra-neural measurements of muscle sympathetic nerve activity (MSNA) in relapsing-remitting multiple sclerosis (MS) patients to test the hypothesis that spontaneous resting MSNA is reduced in MS patients compared to age, sex-matched healthy controls. Spontaneous MSNA (microneurography; peroneal nerve), plasma norepinephrine, arterial blood pressure (finger photoplethysmography), and heart rate were measured at rest in three groups: 1) relapsing remitting MS patients on disease modifying therapy only (MS-DT; n=6); 2) relapsing-remitting MS patients on disease modifying therapy and medications for MS-related symptoms that are known to effect the central nervous system (MS-DT/ST; n=5), and 3) healthy age and sex-matched controls (CON; n=6). Compared to the CON group, MSNA burst frequency (bursts/min) was significantly lower in both MS-DT (P=0.027) and MS-DT/ST groups (P=0.003). Similarly, MSNA burst incidence (bursts/100 heart beats) was significantly reduced in both MS-DT (P=0.049) and MS-DT/ST groups (P=0.004) compared to the CON group. Burst frequency and burst incidence were not different between MS-DT and MS-DT/ST groups. Resting plasma norepinephrine was also significantly lower in both MS-DT (P=0.039) and MS-DT/ST groups (P=0.021) compared to the CON group. Reduced MSNA may signify an important dysfunction in autonomic control of cardiovascular function in patients with MS.

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Section: Discussionmentioning

confidence: 99%

Reduced spontaneous sympathetic nerve activity in multiple sclerosis patients

Keller

Fadel

Harnsberger

et al. 2014

Journal of the Neurological Sciences

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“…The symptoms of major depression were shown to be associated with cardiovascular disease and myocardial infarction (Musselman, Evans, & Nemeroff, 1998). Sympathetic muscle activity in depression patients was higher than in normal subjects, and the muscle activity augmentation effect was reduced after treatment with the antidepressant sertraline (Scalco et al, 2009). Conversely, some data have indicated that depression facilitates the parasympathetic division but not the sympathetic division (Lechin et al, 1995a,b).…”

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confidence: 99%

Effects of stress, depression, and their interaction on heart rate, skin conductance, finger temperature, and respiratory rate: sympathetic‐parasympathetic hypothesis of stress and depression

Lin

et al. 2011

J Clin Psychol

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We examined effects of stress, depression, and their interaction on sympathetic-parasympathetic responses, including percentage heart rate (PHR), percentage skin conductance (PSC), percentage finger temperature (PTEMP), and percentage respiratory rate (PRESPR). Participants were categorized into normal, low-risk, and high-risk depression groups under stress or no-stress by measuring psychophysiological responses. Stress increased PHR and PSC and decreased PTEMP. Depression negatively correlated with PHR and PTEMP. PSC and PTEMP were significantly dependent on and positively correlated with depression. PTEMP was significantly affected by the stress and depression interaction. Stress affects sympathetic, rather than parasympathetic, activity. Depression and the interaction between stress and depression initially associated with the sympathetic division and are then correlated with parasympathetic activity. A sympathetic-parasympathetic hypothesis and its clinical implications are discussed.

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“…Other investigations have found local SNS activity to be associated with depression. Muscle SNS activity was elevated in major depression disorder (MDD) patients that had high depression symptoms compared with MDD patients with lower depression symptoms (10). Despite the lack of relationship between depression and catecholamines in the present study, observed differences in leukocyte β-AR sensitivity in relation to major depression may illustrate that functional measures of SNS may be important in depression studies for examining SNS activation.…”

Section: Discussionmentioning

confidence: 99%

“…This confirms observations from other studies that also did not find a correspondence between depression as a continuous variable and β-AR sensitivity (24). However, some studies have found non-linear relationships between sympathetic activity and depression symptoms (10), 13). For example, the overall rate of spillover of NE to plasma did not differ between the healthy subjects and the patients with major depressive disorder (MDD); whereas the rate of NE spillover to plasma followed a bimodal distribution with a subset of MDD patients having very high sympathetic nervous activity, including sympathetic outflow to the heart (13).…”

Section: Discussionmentioning

confidence: 99%

Leukocyte ß-Adrenergic Receptor Sensitivity and Depression Severity in Patients With Heart Failure

Redwine

Hong

Rutledge³

et al. 2014

Psychosomatic Medicine

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Objectives Clinical outcomes are worse for patients with heart failure (HF) and elevated depression symptoms. Depression related sympatho-immune dysregulation may be one mechanism leading to poorer HF prognosis. Sympathetically mediated adrenergic activity is known to regulate immune activity via β-adrenergic receptors (β-ARs). However, studies show conflicting relationships between leukocyte β-AR sensitivity and depression symptoms. The aim of this study was to determine in patients with HF the relationship of leukocyte β-AR sensitivity with two diverse measures of depression, self-report questionnaire versus clinical diagnostic interview. Methods Patients with HF (N=73, mean age = 56.3, S.D. = 13.0) completed the Beck Depression Inventory −1A (BDI) and a modified Structured Clinical Interview for the DSM-IV (SCID). Leukocyte β-AR sensitivity was determined from isoproterenol stimulated cyclic AMP levels; plasma norepinephrine and epinephrine were also assessed. Results Patients with major depression determined by SCID had significantly higher β-AR sensitivity than non-depressed (F(6, 72) = 9.27, p = .003, η2 = .12). Meanwhile, the BDI revealed a more complex relationship. Minimal, mild, and moderate-to-severe depression symptom groups had significant differences in β-AR sensitivity (F(7, 72) = 7.03, p = .002, η2 = .18), with mild symptoms appearing to correspond with reduced β-AR sensitivity and moderate-to-severe symptoms with higher β-AR sensitivity. Conclusions By deconstructing depression measurements a greater depth of information may be garnered to potentially reveal subtypes of depression symptoms and their relation to β-AR sensitivity in HF.

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Muscle sympathetic nervous activity in depressed patients before and after treatment with sertraline

Abstract: Moderate-to-severe depression is associated with increased MSNA. Sertraline treatment reduces MSNA at rest and during mental challenge in depressed patients, which may have prognostic implications in this group.

Cited by 59 publications

References 59 publications

Reduced spontaneous sympathetic nerve activity in multiple sclerosis patients

Reduced spontaneous sympathetic nerve activity in multiple sclerosis patients

Effects of stress, depression, and their interaction on heart rate, skin conductance, finger temperature, and respiratory rate: sympathetic‐parasympathetic hypothesis of stress and depression

Leukocyte ß-Adrenergic Receptor Sensitivity and Depression Severity in Patients With Heart Failure

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