Muscle-UCP3 in the regulation of energy metabolism

Della Guardia, Lucio; Luzi, Livio; Codella, Roberto

doi:10.1016/j.mito.2024.101872

Cited by 2 publications

(1 citation statement)

References 86 publications

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“…UCP3 is the predominant UCP isoform in skeletal muscle [ 97 ]. Mitochondrial dysfunction in skeletal muscle may be a contributing factor to impaired lipid oxidation, which is associated with decreased expression of the UCP3 protein in muscle [ 98 ].…”

Section: Scfas and Human Glucose And Lipid Metabolismmentioning

confidence: 99%

Mechanisms of regulation of glycolipid metabolism by natural compounds in plants: effects on short-chain fatty acids

Li,

Zhao,

Tian

et al. 2024

Nutr Metab (Lond)

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Background Natural compounds can positively impact health, and various studies suggest that they regulate glucose‒lipid metabolism by influencing short-chain fatty acids (SCFAs). This metabolism is key to maintaining energy balance and normal physiological functions in the body. This review explores how SCFAs regulate glucose and lipid metabolism and the natural compounds that can modulate these processes through SCFAs. This provides a healthier approach to treating glucose and lipid metabolism disorders in the future. Methods This article reviews relevant literature on SCFAs and glycolipid metabolism from PubMed and the Web of Science Core Collection (WoSCC). It also highlights a range of natural compounds, including polysaccharides, anthocyanins, quercetins, resveratrols, carotenoids, and betaines, that can regulate glycolipid metabolism through modulation of the SCFA pathway. Results Natural compounds enrich SCFA-producing bacteria, inhibit harmful bacteria, and regulate operational taxonomic unit (OTU) abundance and the intestinal transport rate in the gut microbiota to affect SCFA content in the intestine. However, most studies have been conducted in animals, lack clinical trials, and involve fewer natural compounds that target SCFAs. More research is needed to support the conclusions and to develop healthier interventions. Conclusions SCFAs are crucial for human health and are produced mainly by the gut microbiota via dietary fiber fermentation. Eating foods rich in natural compounds, including fruits, vegetables, tea, and coarse fiber foods, can hinder harmful intestinal bacterial growth and promote beneficial bacterial proliferation, thus increasing SCFA levels and regulating glucose and lipid metabolism. By investigating how these compounds impact glycolipid metabolism via the SCFA pathway, novel insights and directions for treating glucolipid metabolism disorders can be provided.

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Section: Scfas and Human Glucose And Lipid Metabolismmentioning

confidence: 99%

Mechanisms of regulation of glycolipid metabolism by natural compounds in plants: effects on short-chain fatty acids

Li,

Zhao,

Tian

et al. 2024

Nutr Metab (Lond)

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Role of Abscisic Acid in the Whole-Body Regulation of Glucose Uptake and Metabolism

Spinelli,

Humma,

Magnone

et al. 2024

Nutrients

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Abscisic acid (ABA) is a hormone with a long evolutionary history, dating back to the earliest living organisms, of which modern (ABA-producing) cyanobacteria are likely descendants, which existed long before the separation of the plant and animal kingdoms, with a conserved role as signals regulating cell responses to environmental challenges. In mammals, along with the anti-inflammatory and neuroprotective function of ABA, nanomolar ABA regulates the metabolic response to glucose availability by stimulating glucose uptake in skeletal muscle and adipose tissue via an insulin-independent mechanism and increasing metabolic energy production and also dissipation in brown and white adipocytes. Chronic ABA intake of micrograms per Kg body weight improves blood glucose, lipids, and morphometric parameters (waist circumference and body mass index) in borderline subjects for prediabetes and metabolic syndrome. This review summarizes the most recent in vitro and in vivo data obtained with nanomolar ABA, the involvement of the receptors LANCL1 and LANCL2 in the hormone’s action, and the importance of mammals’ endowment with two distinct hormones governing the metabolic response to glucose availability. Finally, unresolved issues and future directions for the clinical use of ABA in diabetes are discussed.

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Muscle-UCP3 in the regulation of energy metabolism

Cited by 2 publications

References 86 publications

Mechanisms of regulation of glycolipid metabolism by natural compounds in plants: effects on short-chain fatty acids

Mechanisms of regulation of glycolipid metabolism by natural compounds in plants: effects on short-chain fatty acids

Role of Abscisic Acid in the Whole-Body Regulation of Glucose Uptake and Metabolism

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