Muscle wasting after coronary artery bypass graft surgery: impact on post-operative clinical status and effect of exercise-based rehabilitation

Abstract

Background: Coronary artery bypass graft (CABG) surgery is known to induce significant muscle wasting. It remains to be investigated whether muscle wasting after CABG surgery relates to a worse clinical status at entry of rehabilitation and exercise-based rehabilitation remediates such muscle wasting.Design: Prospective observational study. Methods:In 21 males, changes in lean tissue mass (LTM) after CABG surgery were assessed and during a 12-week endurance exercise-based rehabilitation intervention. Changes in blood parameters and cardiopulmonary exercise capcity were assessed, and relations with changes in LTM were analyzed.Results: LTM decreased by -1.9±2.5kg (p<0.05) within 3 weeks after CABG surgery: greater LTM loss related to a lower ventilatory threshold at entry of rehabilitation (r=0.58-0.61, p<0.05). LTM was fully restored (+2.1±2.4kg, p<0.05) during rehabilitation. Conclusion:In males, CABG-induced LTM reduction was associated with a worse aerobic exercise tolerance at entry of rehabilitation, but this LTM reduction was fully remediated by endurance exercise-based rehabilitation.

The Age Factor in Cardiac Rehabilitation

“…12 The increase in METs after CR was varied in some studies. [13][14][15][16] Regarding gender, this study showed that it does not influence the METs difference after CR, which contradicts previous studies reporting significant differences in METs improvement between men and women after CR following PCI or CABG. [16][17][18][19] The gender role mechanism in METs response after CR is not fully understood, but it suggests that socioeconomic and cultural factors, including disparities in health care access, variations in exercise completion, societal expectations, and lifestyle patterns, can also impact CR outcomes.…”

“…In CR outcomes, both genders have positive results as they both have an increased post-CR METs response 12. The increase in METs after CR was varied in some studies 13-16. Regarding gender, this study showed that it does not influence the METs difference after CR, which contradicts previous studies reporting significant differences in METs improvement between men and women after CR following PCI or CABG 16-19.…”

Evaluation of Skeletal Muscle Dysfunction Associated With Acute Inflammation by Electrical Impedance Myography: A Case Report on Skeletal Muscle Dysfunction After Cardiac Surgery and Literature Review

“…Second, follow-up was terminated on POD 14. Muscle strength and PA were reduced compared with preoperative values and discharged from the hospital, generally improved at 12 weeks [ 13 ], which may also prove the value of EIM by evaluating the course of improvement. The results of this case report also warrant further study on acute inflammation of the skeletal muscle and the superior results of the evaluation using EIM.…”

Relationship between Perme ICU Mobility Score and length of stay in patients after cardiac surgery

“…Baseline characteristics and clinical outcomes of polled patients are shown in Table 1. The median [IQR] of the mobility status at ICU admission and ICU discharge to 6 [3][4][5][6][7] points and 27 [23][24][25][26][27][28][29][30] points, respectively (p < 0.001) (Figure 2).…”

“…Coronary artery bypass grafting (CABG) is still the most common cardiac surgery worldwide and is associated with valve replacement; it stands out for its significant economic and social impact 1,2 . Several studies have demonstrated that CABG induced lean tissue mass reduction, loss of handgrip strength, and pulmonary complications 3,4 . In addition, during the first three days after CABG surgery, a significant inflammatory reaction and insulin resistance occurred, and during the first week after CABG, slight vital capacity decreased by 30-60% 5,6 .…”