Muscle wasting in patients with chronic heart failure: results from the studies investigating co-morbidities aggravating heart failure (SICA-HF)

Fülster, Susann; Tacke, Matthias; Sandek, Anja; Ebner, Nicole; Tschöpe, Carsten; Doehner, Wolfram; Anker, Stefan D.; Haehling, Stephan von

doi:10.1093/eurheartj/ehs381

Cited by 518 publications

(513 citation statements)

References 44 publications

Supporting

Mentioning

436

Contrasting

Unclassified

Order By: Relevance

“…This finding is similar to other studies 4. It has been shown that heart failure patients with higher BMI have better outcome in terms of mortality and hospitalization (obesity paradox),20 and the strong association between BMI and muscle wasting in the present study may be an explanation for this finding.…”

Section: Discussionsupporting

confidence: 93%

“…After the first definition of sarcopenia by Irwin Rosenberg, many investigators have studied different aspects of this phenomenon in different subgroups of population including healthy persons and patients suffering from chronic illnesses like chronic heart failure or renal failure 4, 6, 7, 12, 13, 14, 17…”

Section: Discussionmentioning

confidence: 99%

“…Although muscle wasting was first introduced as a phenomenon secondary to ageing, it is more prevalent in patients with a chronic illness such as heart failure, chronic renal failure, and chronic lung disease 1, 6, 7, 8. In most studies regarding muscle wasting in heart failure, elderly patients have been selected 2, 3, 4, 5, 9. The results of these studies indicate a higher prevalence of muscle wasting in older patients with heart failure compared with healthy subjects who are at the same age 2, 3, 4, 5, 9.…”

Section: Introductionmentioning

confidence: 99%

“…In most studies regarding muscle wasting in heart failure, elderly patients have been selected 2, 3, 4, 5, 9. The results of these studies indicate a higher prevalence of muscle wasting in older patients with heart failure compared with healthy subjects who are at the same age 2, 3, 4, 5, 9. There are only scant data regarding the presence of muscle wasting in younger patients with heart failure,3 and it is not known whether heart failure could possibly be a risk factor for muscle wasting regardless of ageing process or not.…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Muscle wasting in young patients with dilated cardiomyopathy

Hajahmadi

Shemshadi

Khalilipur

et al. 2017

J cachexia sarcopenia muscle

View full text Add to dashboard Cite

BackgroundMuscle wasting can be accelerated by chronic diseases such as heart failure and is one of the major causes of disability, morbidity, and mortality in this population. We aimed to investigate the incidence of muscle wasting and its associated factors in dilated cardiomyopathy patients younger than 55 years of age.MethodsBetween April 2014 and December 2015, all symptomatic patients with a diagnosis of non‐ischaemic dilated cardiomyopathy who were referred to heart failure clinic were included in our study.Dual energy X‐ray absorptiometry was used to evaluate body composition and identify muscle wasting. Muscle mass was calculated as the ratio of an individual's total lean mass of legs and arms (also called appendicular skeletal muscle) to their squared height (kg/m2). The muscle mass values of less than 5.45 kg/m2 for women and 7.26 kg/m2 for men were considered low.ResultsA total of 55 patients (32 male) were included. The mean (standard deviation) of age was 37.3 (10.1) years, and the mean of left ventricular ejection fraction was 21.4%. Most of the patients were in the New York Heart Association classes of II and II–III. Twenty‐six patients (47.3%) met criteria for muscle wasting. Patients with muscle wasting had lower left ventricular ejection fraction, lower 6‐min walk distance, and higher New York Heart Association function class and hospitalization rate.ConclusionsWe concluded that muscle wasting might be present in younger patients with heart failure, particularly in those who are in worse clinical condition.

show abstract

Section: Discussionsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Muscle wasting in young patients with dilated cardiomyopathy

Hajahmadi

Shemshadi

Khalilipur

et al. 2017

J cachexia sarcopenia muscle

View full text Add to dashboard Cite

show abstract

“…have previously suggested that repeated administration of ghrelin may improve left ventricular function, exercise capacity, and reduce muscle wasting in patients with HF. Because the relevance of sarcopenia in the clinical picture of HF22 is growing and approximately 20% of HF patients with an average age of nearly 70 years may meet the criteria for diagnosing sarcopenia,23 ghrelin may be an interesting treatment strategy to tackle the wasting continuum in HF 24…”

Section: Discussionmentioning

confidence: 99%

Ghrelin and hormonal markers under exercise training in patients with heart failure with preserved ejection fraction: results from the Ex‐DHF pilot study

et al. 2016

View full text Add to dashboard Cite

BackgroundOver 50% of patients with symptomatic heart failure (HF) experience HF with preserved ejection fraction (HFpEF). Exercise training (ET) is effective in improving cardiorespiratory fitness and dimensions of quality of life in patients with HFpEF. A systemic pro‐inflammatory state induced by comorbidities as the cause of myocardial structural and functional alterations has been proposed in HFpEF. ET modifies myocardial structure and has been related to inflammatory state. We investigated Ghrelin, related adipokines, markers of inflammation, and neuro‐hormonal activation in patients undergoing a structured ET vs. usual care are with HFpEF. Methods and resultsEx‐DHF‐P was a prospective, controlled, randomized multi‐centre trial on structured and supervised ET in patients with HFpEF. We performed a post hoc analysis in 62 patients from Ex‐DHF‐P. Ghrelin, adiponectin, leptin, IL‐1ß, IL‐6, IL‐10, tumour necrosis factor‐alpha, MR‐proANP, MR‐proADM, CT‐proET1, and CT‐proAVP were assessed to seize the impact of ET on these markers in patients with HFpEF. Thirty‐six (58%) patients were female, mean age was 64 years, and median ghrelin was 928 pg/mL (interquartile range 755–1156). When stratified for high versus low ghrelin, groups significantly differed at baseline in presence obesity, waist circumference, and adiponectin levels (P < 0.05, respectively). Overall, ghrelin levels rose significantly to 1013 pg/mL (interquartile range 813–1182) (P < 0.001). Analysis of covariance modelling for change in ghrelin identified ET (P = 0.013) and higher baseline adiponectin levels (P = 0.035) as influencing factors.ConclusionsExercise training tended to increase ghrelin levels in Ex‐DHF‐P. This increase was especially pronounced in patients with higher baseline adiponectin levels. Future trials are needed to investigate the effect of ET on endogenous ghrelin levels in regard to interactions with cardiac structure and clinically meaningful surrogate parameters.

show abstract

Sarcopenia and Other Chronic Organ Diseases

Arai

2021

Sarcopenia

View full text Add to dashboard Cite

Muscle wasting in patients with chronic heart failure: results from the studies investigating co-morbidities aggravating heart failure (SICA-HF)

Abstract: Muscle wasting is a frequent co-morbidity among patients with chronic HF. Patients with muscle wasting present with reduced exercise capacity and muscle strength, and advanced disease.

Cited by 518 publications

References 44 publications

Muscle wasting in young patients with dilated cardiomyopathy

Muscle wasting in young patients with dilated cardiomyopathy

Ghrelin and hormonal markers under exercise training in patients with heart failure with preserved ejection fraction: results from the Ex‐DHF pilot study

Sarcopenia and Other Chronic Organ Diseases

Contact Info

Product

Resources

About