Muscoloskeletal aging, sarcopenia and cancer

Colloca, G.; Capua, Beatrice Di; Bellieni, Andrea; Cesari, Matteo; Marzetti, Emanuele; Valentini, Vincenzo; Calvani, Riccardo

doi:10.1016/j.jgo.2018.11.007

Cited by 50 publications

(45 citation statements)

References 82 publications

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“…Sarcopenia in cancer patients might be caused by several factors; for example, inactivity, malnutrition, and cancer-related cytokines [40]. Another factor that might influence sarcopenia in gastric cancer patients is tumor (lymph) nodes metastasis (TNM) stage.…”

Section: Discussionmentioning

confidence: 99%

The Predictive Value of Low Muscle Mass as Measured on CT Scans for Postoperative Complications and Mortality in Gastric Cancer Patients: A Systematic Review and Meta-Analysis

Borggreve

Boer

Boxel

et al. 2020

JCM

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Risk assessment is relevant to predict outcomes in patients with gastric cancer. This systematic review aimed to investigate the predictive value of low muscle mass for postoperative complications in gastric cancer patients. A systematic literature search was performed to identify all articles reporting on muscle mass as measured on computed tomography (CT) scans in patients with gastric cancer. After full text screening, 15 articles reporting on 4887 patients were included. Meta-analysis demonstrated that patients with low muscle mass had significantly higher odds of postoperative complications (odds ratio (OR): 2.09, 95% confidence interval (CI): 1.55–2.83) and severe postoperative complications (Clavien–Dindo grade ≥III, OR: 1.73, 95% CI: 1.14–2.63). Moreover, patients with low muscle mass had a significantly higher overall mortality (hazard ratio (HR): 1.81, 95% CI: 1.52–2.14) and disease-specific mortality (HR: 1.58, 95% CI: 1.36–1.84). In conclusion, assessment of muscle mass on CT scans is a potential relevant clinical tool for risk prediction in gastric cancer patients. Considering the heterogeneity in definitions applied for low muscle mass on CT scans in the included studies, a universal cutoff value of CT-based low muscle mass is required for more reliable conclusions.

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Section: Discussionmentioning

confidence: 99%

The Predictive Value of Low Muscle Mass as Measured on CT Scans for Postoperative Complications and Mortality in Gastric Cancer Patients: A Systematic Review and Meta-Analysis

Borggreve

Boer

Boxel

et al. 2020

JCM

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mentioning

confidence: 99%

“…Secondary sarcopenia is frequently detected in elderly cancer patients and is a pathophysiological feature of cancer cachexia, a metabolic syndrome, characterized by cytokine-mediated degradation of muscle mass [1]. Etiologic factors of cachexia are higher levels of energy consumption through metabolic changes and inflammation, combined with malnutrition and decreased muscular activity [1]. In this state, the tumor and its microenvironment secrete pro-inflammatory and catabolic cytokines such as TNFs, IL-1 and proteolysis-inducing factor (PIF), which in turn lead to release of several myofibrillar proteins that activate cascades resulting in muscular atrophy.…”

mentioning

confidence: 99%

Sarcopenia in cancer—a focus on elderly cancer patients

Marhold

Topakian

Unseld

2020

memo

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SummaryGeriatric assessments, nutritional counseling and monitoring of muscle health before and during therapy are of high clinical significance in the management of elderly cancer patients. Criteria, data and cut-offs characterizing cancer-related geriatric sarcopenia are sparse and no consensus about definitions exists to date. We hence highlight a need for clinical trials focusing on sarcopenia in elderly cancer patients, based on its high prevalence and potential negative consequences on therapy outcomes, mortality, quality of life and physical mobility.

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“…It is worth to mention that BT plays an important role in treating elderly patients, particularly unfit, frail, or sarcopenic, in which a conservative therapeutic approach may be the best choice [15]. Analyzing the international scenario in terms of cultural background, it becomes clear that there is an adequate attention and consideration towards BT, supported by the presence of dedicated guidelines, with regard to several anatomical sites issued by the main European [16,17,18,19,20,21,22,23,24,25] and American societies [26,27,28].…”

Section: Airo Interventional Radiotherapy Study Group "State Of the Amentioning

confidence: 99%

Can brachytherapy be properly considered in the clinical practice? Trilogy project: The vision of the AIRO (Italian Association of Radiotherapy and Clinical Oncology) Interventional Radiotherapy study group

Tagliaferri¹,

Vavassori²,

Lancellotta³

et al. 2020

jcb

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Purpose: Brachytherapy (BT, interventional radiotherapy-IRT) is a kind of radiation therapy, in which the radioactive source is placed nearby or even inside the cancer itself. Even though this kind of radiation therapy appears effective and valuable, BT has been facing a slow but progressive decline over the past decades in Europe, particularly in Italy. Aims of this study were to identify the practical and theoretical reasons why BT is facing a slow decline in Italy, and to define a vision of the Italian Association of Radiotherapy and Clinical Oncology (AIRO) and a strategy about this emerged issues. Material and methods: A programmatic path divided into three steps like a trilogy was launched by AIRO Interventional Radiotherapy study group. The study group performed an initial data collection to highlight both the clinical and the educational topics and problems through specific surveys. After having analyzed the results of the surveys and shared a vision about the emerged issues, a specific strategy was adopted. Results: Four relevant domains were identified and for each ones, a strategy has been discussed and defined. This manuscript shows in detail the individual actions defined (accomplished or in progress). Conclusions: The AIRO vision implies that specific strategic interventions must be carried out in the field of national guidelines, education, research, and communication with patients and colleagues of other specialties in an interdisciplinary setting.

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Muscoloskeletal aging, sarcopenia and cancer

Cited by 50 publications

References 82 publications

The Predictive Value of Low Muscle Mass as Measured on CT Scans for Postoperative Complications and Mortality in Gastric Cancer Patients: A Systematic Review and Meta-Analysis

The Predictive Value of Low Muscle Mass as Measured on CT Scans for Postoperative Complications and Mortality in Gastric Cancer Patients: A Systematic Review and Meta-Analysis

Sarcopenia in cancer—a focus on elderly cancer patients

Can brachytherapy be properly considered in the clinical practice? Trilogy project: The vision of the AIRO (Italian Association of Radiotherapy and Clinical Oncology) Interventional Radiotherapy study group

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