Muscular atrophy of the lower leg in unilateral post traumatic osteoarthritis of the ankle joint

Wiewiorski, Martin; Dopke, Kai; Steiger, Christina; Valderrábano, Víctor

doi:10.1007/s00264-012-1594-6

Cited by 32 publications

(27 citation statements)

References 28 publications

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“…The binary masks were subsequently applied on maps of T2, MD, FA, RD, and fat fraction to generate the average value. Muscle volumes of soleus were also quantified as the cross‐sectional area on the central slice of the T1‐weighted anatomic image . Eighteen subjects per group sufficiently afforded >80% power to detect an effect size of 0.85, with a measurement error of 30% at an alpha of 0.05 (as measured by PCr recovery halftime).…”

Section: Methodsmentioning

confidence: 99%

Metabolic and Structural Skeletal Muscle Health in Systemic Lupus Erythematosus–Related Fatigue: A Multimodal Magnetic Resonance Imaging Study

Cheung

Keenan

Senn

et al. 2019

Arthritis Care & Research

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Objective. To investigate the potential structural and metabolic role of skeletal muscle in systemic lupus erythematosus (SLE)-related fatigue.Methods. A case-control, multimodal magnetic resonance imaging (MRI) study was conducted. Cases were patients with inactive SLE who reported chronic fatigue. Controls were age-and sex-matched healthy members of the general population. Patients were clinically characterized and then underwent a 3T whole-body MRI scan. Resting and dynamic 31 P MRI spectroscopy of the calf muscles was applied, from which phosphocreatine (PCr) recovery halftime, a marker of mitochondrial dysfunction, was computed. In addition, microstructural sequences (T1-weighted anatomic images, T2 mapping, and diffusion tensor imaging) were acquired. Descriptive statistics evaluated group differences and within-case physical fatigue correlations were explored.Results. Of the 37 recruits (mean age 43.8 years, 89.2% female), cases (n = 19) reported higher levels of physical fatigue, pain, depression, and sleep disturbance compared to the control group (P < 0.0001). PCr was greater (P = 0.045) among cases (mean ± SD 33.0 ± 9.0 seconds) compared to controls (mean ± SD 27.1 ± 6.6 seconds). No microstructural group differences were observed. Within cases, physical fatigue did not correlate with PCr (r = -0.28, P = 0.25).Conclusion. We report preliminary data demonstrating greater skeletal muscle mitochondrial dysfunction among fatigued patients with SLE compared to healthy controls.

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Section: Methodsmentioning

confidence: 99%

Metabolic and Structural Skeletal Muscle Health in Systemic Lupus Erythematosus–Related Fatigue: A Multimodal Magnetic Resonance Imaging Study

Cheung

Keenan

Senn

et al. 2019

Arthritis Care & Research

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“…for review). Given that intramuscular adipose has been shown to increase and muscle mass has been shown to decrease in individuals with OA, longitudinal research is needed to quantify the extent to which these parameters change before versus after surgery. The fact that the current study demonstrated that no changes occur in the relative size of the muscle compartments between the fused and control limbs supports the theory that changes in tissue composition may occur pre‐operatively.…”

Section: Discussionmentioning

confidence: 99%

“…The paucity of data examining muscle function following tibiotalar arthrodesis limits our understanding of the relationship between tibiotalar joint motion, ankle strength, and post‐operative impairments. For example, end‐stage ankle OA is known to cause muscle atrophy, and studies postulate that this atrophy occurs because individuals limit their activities to avoid pain . If true, atrophy should reverse post‐operatively due to the elimination of pain.…”

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confidence: 99%

Ankle strength, muscle size, and adipose content following unilateral tibiotalar arthrodesis

Nichols

Foreman

Barg

et al. 2019

Journal Orthopaedic Research

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Tibiotalar arthrodesis is commonly used to treat end-stage ankle osteoarthritis. Post-operative impairments are often attributed to limited ankle motion. However, whether muscular deficits also exist, thereby potentially contributing to impairments, is unknown. This study aimed to identify post-operative deficits in ankle musculature by examining range of motion, strength (maximum isometric ankle joint torque), and leg composition (cross-sectional area of individual tissue types: bone, subcutaneous adipose, intramuscular adipose, muscle). Ten individuals with unilateral tibiotalar arthrodesis participated. Paired t-tests (p < 0.05) identified differences between the fused and contralateral, control limb. The results indicate that individuals with tibiotalar arthrodesis have profound losses of range of motion and strength. Across participants, range of motion in the fused limb was 53.5 AE 11.7%, 66.8 AE 6.3%, 38.2 AE 18.7%, 37.8 AE 13.6% less than the control for dorsiflexion, plantarflexion, inversion, and eversion, respectively. The largest strength deficit was in dorsiflexion, with the fused limb producing 47.2 AE 9.4% less torque than the control. The quantity and quality of muscle tissue was also negatively affected in individuals following tibiotalar arthrodesis. The total cross-sectional area of the fused limb was 11.4 AE 5.4% smaller than the control limb. This change was primarily due to the 16.1 AE 6.7% decrease in muscle cross-sectional area. However, intramuscular adipose was significantly increased. Although the posterior compartment demonstrated a significant decrease in cross-sectional area, when accounting for differences in total cross-sectional area, the relative sizes of the four muscle compartments were consistent between limbs. This cross-sectional study motivates longitudinal research examining muscular deficits and whether these deficits are reversible with exercise and rehabilitation. ß

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“…Furthermore, the major postural muscles of the lower limbs including quadriceps, gluteus, and hamstrings are affected (wasting and or compensatory over activity) with arthrosis of knee and hip joints [25][26][27] , affecting the balance and increasing the risk of fall. Muscles affected significantly in end stage ankle arthrosis include medial soleus and only fatty degeneration was reported in other muscles [28] . This may be the reason postural stability remains preserved in ankle arthrosis as well as why gait variability parameters are not as important in ankle arthrosis as they are in arthrosis of other weight bearing joints.…”

Section: Discmentioning

confidence: 99%

Outcome of ankle arthrodesis and total ankle replacement for ankle arthrosis in terms of gait variability

Chopra

Rouhani

Moerenhout

et al. 2015

JBEI

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Background: Higher variability in gait parameters has been reported in patients' with arthrosis of hip and knee joints, leading to dynamic instability and increased risk of falling. Higher variability and gait instability has also been noted to persist months after surgery. Ankle arthrosis is likely similar, but information regarding this is lacking. The purpose of the study was to evaluate gait variability following ankle arthrosis and its surgical treatments, ankle arthrodesis and total ankle replacement.Methods: Seventy participants, divided into controls, ankle arthrosis, ankle arthrodesis and total ankle replacement, performed gait assessment wearing 3-D inertial sensors through which gait parameters and the variability were compared among groups. Correlations between American Orthopedic Foot and Ankle score and Foot and Ankle Ability Measure score with the gait parameters and their variability were calculated.Results: All three case groups reported gait variability similar to that of the controls. On the contrary, significant differences (P < .01) were reported in several gait parameters when compared to the controls in all case groups. Furthermore, both clinical scores showed little to no correlation with gait variability and a good correlation was reported with gait parameters (P < .0001). Conclusions:The study did not find gait variability to be as reliable compared with gait parameters when assessing the outcome of ankle surgeries. Furthermore, among the gait parameters, walking speed showed a strong correlation with the patients' functional status and is confirmed as an important parameter for ankle arthrosis. Key wordsEnd stage ankle surgeries, American orthopaedic foot and ankle score, Foot and ankle ability measure, Outcome evaluation, Gait assessment

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Muscular atrophy of the lower leg in unilateral post traumatic osteoarthritis of the ankle joint

Cited by 32 publications

References 28 publications

Metabolic and Structural Skeletal Muscle Health in Systemic Lupus Erythematosus–Related Fatigue: A Multimodal Magnetic Resonance Imaging Study

Metabolic and Structural Skeletal Muscle Health in Systemic Lupus Erythematosus–Related Fatigue: A Multimodal Magnetic Resonance Imaging Study

Ankle strength, muscle size, and adipose content following unilateral tibiotalar arthrodesis

Outcome of ankle arthrodesis and total ankle replacement for ankle arthrosis in terms of gait variability

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