Muscular blood flow responses as an early predictor of the severity of diabetic neuropathy at a later stage in streptozotocin-induced type I diabetic rats: a diffuse correlation spectroscopy study

Ono, Yumie; Esaki, Kimiya; Takahashi, Yuta; Nakabayashi, Mikie; Ichinose, Masashi; Lee, Kijoon

doi:10.1364/boe.9.004539

Cited by 17 publications

(22 citation statements)

References 28 publications

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“…It has been reported that microvascular malfunctions of muscle tissue are affected by hyperglycemia and are correlated with the severity of diabetic neuropathy in later stages. 80 With the development of HRU, muscle atrophy (resulting from a variety of factors) can be identified at an earlier stage. The lack of research on the normal value of muscle observed by ultrasound and the diagnostic value of muscle in patients with DA necessitates further study using HRU of the characteristics of various neurologic diseases.…”

Section: Diagnosis Of Diabetic Muscular Atrophymentioning

confidence: 99%

Application of High-Resolution Ultrasound on Diagnosing Diabetic Peripheral Neuropathy

Huang¹,

Wu²

2021

DMSO

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Diabetic peripheral neuropathy (DPN) is a common complication of diabetes mellitus (DM). The typical manifestation is a length-dependent "glove and sock" sensation. At present, diagnosis is mainly dependent on clinical manifestations. Since the pathogenesis is not clear, there are no effective treatment measures. Management consists mainly of glucose control, peripheral nerve nutrition, and other measures to delay the progress of the disease; early diagnosis is therefore crucial to improving prognosis and quality of life for patients with DPN. Due to the lack of obvious symptoms in 50% of patients and the low sensitivity of neuro-electrophysiology to small fibers, the missed diagnosis rate is high. Highresolution ultrasound (HRU), as a convenient noninvasive tool, has been proven by many studies to have excellent clinical value in diagnosing DPN. With the development of related new technology, HRU shows promise for the screening, diagnosing, and follow-up of DPN, which could serve as a biomarker and provide new diagnostic insights. In this paper, we review the ability of HRU to detect nerve cross-sectional area and blood flow, and echo and other image changes, and in showing the characteristics of peripheral nerve morphological changes in patients with DPN. We also explore the application of two other recent technological developments-shear wave elastography (SWE) and ultrasound scoring systems-in improving the diagnostic efficiency of HRU in peripheral neuropathy.

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Section: Diagnosis Of Diabetic Muscular Atrophymentioning

confidence: 99%

Application of High-Resolution Ultrasound on Diagnosing Diabetic Peripheral Neuropathy

Huang¹,

Wu²

2021

DMSO

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“…In future work, we intend to compare the results between diabetic patients and healthy subjects to assess the key factors distinguishing these two groups, so that early diagnosis of diabetic complications may be possible. To date, some research groups have studied the early diagnosis of diabetic complications using optical systems with near-infrared sources 44 – 46 . However, these studies have focused on the time-averaged hemodynamic variables and disregarded LFO information.…”

Section: Discussionmentioning

confidence: 99%

Low frequency oscillations assessed by diffuse speckle contrast analysis for foot angiosome concept

Yeo

Jung

Lee

et al. 2020

Sci Rep

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An angiosome refers to a 3D tissue volume that is vascularized by a single artery and is a relatively new concept that is useful in vascular surgery; however, the direct relationship between arterial blood flow and micro-perfusion is still controversial. Here, we propose a diffuse speckle contrast analysis (DSCA), which is an emerging tissue perfusion monitoring modality, to investigate the correlations among low frequency oscillations (LFOs) measured from different areas on the feet of healthy subjects. We obtained reproducible results from the correlation analyses of LFOs, and their physiological implications were discussed. In order to confirm the changes in the frequency oscillations, we analyzed and compared the power spectral density changes due to heart rate variability in the electrocardiographic signal during reactive hyperemia and head-up tilt protocols.

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“…A detailed description of the DCS system is provided elsewhere (Nakabayashi and Ono ; Ono et al. ). Briefly, the system consists of a long coherence, continuous wave laser operating at 785 nm (DL 785‐100‐S, 100 mW; CrystaLaser, USA), which serves as the source, and a photon‐counting avalanche‐photodiode, which serves as the detector (COUNT‐T‐100‐FC; Laser Components, Germany).…”

Section: Methodsmentioning

confidence: 99%

“…; Frisbee ; Ono et al. ). Elevated adrenergic vascular tone is one of the factors that compromises the capacity for vasodilation in such pathological states as diabetes mellitus and metabolic syndrome (Friedman ; Frisbee , ; Ono et al.…”

Section: Introductionmentioning

confidence: 99%

“…Elevated adrenergic vascular tone is one of the factors that compromises the capacity for vasodilation in such pathological states as diabetes mellitus and metabolic syndrome (Friedman ; Frisbee , ; Ono et al. ). It has been shown, for example, that sympathetic vascular tone in humans restrains PORH assessed in the forearm as a whole (Sinoway et al.…”

Section: Introductionmentioning

confidence: 99%

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Difference in the integrated effects of sympathetic vasoconstriction and local vasodilation in human skeletal muscle and skin microvasculature

2019

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We investigated the integration of sympathetic vasoconstriction and local vasodilation in the skeletal muscle and skin microvasculature of humans. In 39 healthy volunteers, we simultaneously measured the blood flow index in the flexor carpi radialis muscle using diffuse correlation spectroscopy and the skin using laser‐Doppler flowmetry. We examined the effects of acute sympathoexcitation induced by forehead cooling on relatively weak and robust vasodilatory responses during postocclusive reactive hyperemia ( PORH ) induced by 70‐sec and 10‐min arterial occlusion in the upper arm. To increase sympathetic tone during PORH , forehead cooling was begun 60 sec before the occlusion release and ended 60 sec after the release. In the 70‐sec occlusion trials, acute sympathoexcitation reduced the peak and duration of vasodilation in both skeletal muscle and skin. The inhibition of vasodilation by sympathoexcitation was blunted in both tissues by the robust vasodilatory stimulation produced by the 10‐min occlusion, and the degree of blunting was greater in skeletal muscle than in skin, especially the initial and peak responses. Sympathoexcitation reduced the peak vasodilation only in skin, while it accelerated the initial vasodilation only in skeletal muscle. However, the decline in vasodilation after the peak was significantly hastened in skeletal muscle, shortening the duration of the vasodilation. We conclude that, in humans, the integration of sympathetic vasoconstriction and local vasodilation has different effects in skeletal muscle and skin and is likely an important contributor to the selective control of perfusion in the microcirculations of different tissues.

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Muscular blood flow responses as an early predictor of the severity of diabetic neuropathy at a later stage in streptozotocin-induced type I diabetic rats: a diffuse correlation spectroscopy study

Cited by 17 publications

References 28 publications

Application of High-Resolution Ultrasound on Diagnosing Diabetic Peripheral Neuropathy

Application of High-Resolution Ultrasound on Diagnosing Diabetic Peripheral Neuropathy

Low frequency oscillations assessed by diffuse speckle contrast analysis for foot angiosome concept

Difference in the integrated effects of sympathetic vasoconstriction and local vasodilation in human skeletal muscle and skin microvasculature

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