Muscular Echovariation: A New Biomarker in Amyotrophic Lateral Sclerosis

Martínez-Payá, J.J.; Baño-Aledo, María Elena del; Ríos-Díaz, José; Tembl-Ferrairó, Jose Ignacio; Vázquez-Costa, Juan Francisco; Medina-Mirapeix, Françesc

doi:10.1016/j.ultrasmedbio.2017.02.002

Cited by 48 publications

(60 citation statements)

References 24 publications

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“…Martínez-Payá et al (2017) studied muscle echovariance as a means of quantifying the changes seen in ALS. 31 In principal, higher variation in EI (i.e., more heterogeneity) is found in healthy muscle as opposed to ALS, in which the signal becomes more homogeneous. To investigate the utility of this approach, bilateral, transverse ultrasound of biceps/brachialis, forearm flexor group, quadriceps femoris, and tibialis anterior was performed in patients with ALS and matched healthy controls.…”

Section: Muscle Ultrasound In Alsmentioning

confidence: 94%

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Ultrasound in the Diagnosis and Monitoring of Amyotrophic Lateral Sclerosis: A Review

Hobson‐Webb

Simmons

2019

Muscle and Nerve

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Neuromuscular ultrasound is complementary to electrodiagnostic (EDx) testing and is useful in enhancing the diagnosis of mononeuropathies, peripheral nerve trauma, and demyelinating polyneuropathies. There is increasing interest in using ultrasound both to aid in the diagnosis of amyotrophic lateral sclerosis (ALS) and to monitor its progression. In this article we review the relevant literature on ultrasound in ALS. Ultrasound is more sensitive than EDx in identifying fasciculations in patients with ALS. It can detect decreased muscle thickness, increased muscle echointensity and echovariance, and reduced peripheral nerve size in these patients. Ultrasound is also a helpful tool in assessment of diaphragm function. Although additional studies are required to define the exact role of ultrasound in the evaluation and monitoring of ALS, it can improve the diagnostic yield in patients when ALS is suspected, but insufficiently supported, by clinical and EDx examinations. Muscle Nerve 60: 114–123, 2019

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Section: Muscle Ultrasound In Alsmentioning

confidence: 94%

“…Martínez‐Payá et al . (2017) studied muscle echovariance as a means of quantifying the changes seen in ALS . In principal, higher variation in EI (i.e., more heterogeneity) is found in healthy muscle as opposed to ALS, in which the signal becomes more homogeneous.…”

Section: Muscle Ultrasound In Alsmentioning

confidence: 99%

Ultrasound in the Diagnosis and Monitoring of Amyotrophic Lateral Sclerosis: A Review

Hobson‐Webb

Simmons

2019

Muscle and Nerve

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“…First-order statistical ultrasound parameter included the mean value of pixel reflection or echointensity, and the echovariation of the LM at resting from the CSA and the selected ROI ( Figure 2 B,C). As recommended by Ríos et al [ 53 ], the echointensity was calculated by the relationship between standard deviation and the echointensity (Echointensity = SD/echointensity *100) in order to obtain information about tissue homogeneity.…”

Section: Methodsmentioning

confidence: 99%

“…Moreover, the recently used first-order statistical parameter of echovariation has been suggested as potential biomarker of tissue homogeneity and uniformity of the pixel’s appearance across the selection area. Echovariation describes the degree of gray dispersion from the average value [ 53 , 54 ] through the relationship between the standard deviation (SD) and the mean pixel value of the histograms displayed from the ROI. Echovariation aims to improve the interpretation of the muscle echogenicity in combination with echointensity, which only considers the average of pixel’s intensity from the region selected.…”

Section: Introductionmentioning

confidence: 99%

Quantitative Ultrasound Imaging Differences in Multifidus and Thoracolumbar Fasciae between Athletes with and without Chronic Lumbopelvic Pain: A Case-Control Study

Almazán-Polo

López‐López

Romero‐Morales

et al. 2020

JCM

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New trends in ultrasound imaging are focused on exploration of morphology and muscle quality. The main goal of the study was to evaluate the first-order descriptor and echostructure of lumbar multifidus at the L4 vertebral level in athletes with and without chronic lumbopelvic pain (CLPP). A case-control study was performed in 15 semiprofessional athletes with CLPP and 15 without (healthy athletes). Lumbar multifidus echointensity and echovariation were measured for muscle quality assessment. Echostructure was used to evaluate lumbar multifidus cross-sectional area (CSA) at resting and during muscle contraction, respective differences during both phases (CSADif.), activation patterns, and thoracolumbar fasciae morphology and thickness. Significant differences with a large effect size were observed in quantitative data from CLPP and healthy athletes for left lumbar multifidus CSADif. and thoracolumbar fasciae morphology. Categorical data showed statistically significant differences with a small-to-moderate effect size for lumbar multifidus activation pattern and thoracolumbar fasciae morphology. Athletes with CLPP showed a reduced CSA difference between lumbar multifidus contraction and at resting and higher disorganization of thoracolumbar fasciae morphology compared to healthy athletes. These findings suggest the importance of dynamic exploration of the lumbar region and connective tissue in sports performance and injury prevention.

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“…To date, real-time ultrasound imaging has been used as a non-expensive, portable, non-invasive and safe tool with excellent diagnostic accuracy, which was commonly used to provide indirect and direct information about various vessels features in both extracranial and intracranial structures during the stroke disease course [ 25 ]. Currently, quantitative ultrasound may be considered as a potential biomarker and a complementary modality for the assessment of neurological conditions such as Duchenne muscular dystrophy [ 15 , 26 ] and amyotrophic lateral sclerosis [ 27 , 28 , 29 ]. Nevertheless, these analyses should be replicated in the stroke disease course including the AbH muscle based on our findings.…”

Section: Discussionmentioning

confidence: 99%

Quantitative Ultrasound Imaging Pixel Analysis of the Intrinsic Plantar Muscle Tissue between Hemiparesis and Contralateral Feet in Post-Stroke Patients

Calvo‐Lobo

Useros-Olmo

Almazán-Polo

et al. 2018

IJERPH

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Quantitative ultrasound imaging of the muscle tissue may be applied in the neurology field, due to B-mode grayscale pixels values could be used as potential biomarkers for disease progression and intervention effects in poststroke patients. Thus, the study aim was to compare and analyze the ultrasound imaging B-mode pixels differences between the intrinsic plantar muscles cross-sectional area (CSA) in hemiparetic and contralateral feet from poststroke patients by means of the Image J software. A case-control design and a convenience sampling method were used in order to recruit 22 feet from 11 poststroke patients. This total sample was divided into 11 hemiparetic feet and 11 contralateral feet. The Image J software was used in order to evaluate the interface distance, CSA as well as measure the pixels mean, standard deviation (SD) and count from all offline images in the flexor digitorum brevis, abductor hallucis (AbH), and flexor hallucis brevis muscles. Statistically significant differences (p = 0.003) were only shown for the pixels count in the AbH muscle. The rest of outcome measurements did not show any statistically significant difference (p > 0.05). Therefore, B-mode ultrasound imaging Image J software differences for the pixels count reduction were shown in the AbH muscle between hemiparetic and contralateral feet from poststroke patients. Further studies are necessary in order to apply our findings as potential biomarkers during the stroke disease course.

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Muscular Echovariation: A New Biomarker in Amyotrophic Lateral Sclerosis

Cited by 48 publications

References 24 publications

Ultrasound in the Diagnosis and Monitoring of Amyotrophic Lateral Sclerosis: A Review

Ultrasound in the Diagnosis and Monitoring of Amyotrophic Lateral Sclerosis: A Review

Quantitative Ultrasound Imaging Differences in Multifidus and Thoracolumbar Fasciae between Athletes with and without Chronic Lumbopelvic Pain: A Case-Control Study

Quantitative Ultrasound Imaging Pixel Analysis of the Intrinsic Plantar Muscle Tissue between Hemiparesis and Contralateral Feet in Post-Stroke Patients

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