Muscular involvement of extranodal natural killer/T cell lymphoma misdiagnosed as polymyositis: A case report and review of literature

Liu, Lihui; Huang, Qing; Liu, Yunhai; Yang, Jie; Han, Fei; Lin, Jinxi

doi:10.12998/wjcc.v8.i5.963

Cited by 7 publications

(4 citation statements)

References 17 publications

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“…Imaging modalities including computed tomography (CT), magnetic resonance imaging (MRI), and 18 F-FDG PET/CT have been used to evaluate muscle lymphoma in case series and case reports. In previously published studies, ENKTCL invading the muscle showed slightly hypodense on CT, hypointense on T1WI sequence on MRI, heterogeneously hyperintense on T2WI sequence, and markedly heterogeneous enhancement on contrast-enhanced T1WI [7,10,11]. 18 F-FDG PET/CT plays an important role in the diagnosis, staging and prognostic assessment of lymphoma, including NK/T cell lymphoma [12][13][14].…”

Section: Discussionmentioning

confidence: 96%

“…18 F-FDG PET/CT plays an important role in the diagnosis, staging and prognostic assessment of lymphoma, including NK/T cell lymphoma [12][13][14]. Due to the rarity of ENKTCL invading muscles, only a few case studies have reported its PET/CT ndings, showing high radioactive uptake, with SUVmax ranging from 3.6 to 26.5 [7,9,10]. Our patient presented with multiple, slightly hypodense soft-tissue masses on PET/CT, with ill-de ned borders and prominent FDG uptake, broadly consistent with previous reports.…”

Section: Discussionmentioning

confidence: 99%

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A Case of Nasal Extranodal NK/T-cell Lymphoma of Lower Limb Muscle Revealed by 18F-FDG PET/CT

Hu,

Li,

et al. 2024

CMIR

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Background:: Extranodal NK/T-cell lymphoma (ENKTCL) is a type of malignant non-Hodgkin’s lymphoma originating from mature T cells and NK cells, mainly involving the upper aerodigestive tract, including the nasal cavity, nasopharynx, oropharynx, oral cavity, hypopharynx, larynx, and occasionally the skin, salivary glands, testes, and gastrointestinal tract, but rarely the skeletal muscle. Case Presentation:: An 82-year-old man presented with redness, swelling, and pain in his right lower limb for 3 months. He was initially diagnosed with cellulitis at another hospital and was treated conservatively for two weeks without improvement. He underwent a biopsy of the lesioned muscle and histopathology revealed nasal type ENKTCL. 18F-FDG PET/CT was recommended for the staging of the lymphoma, and the results showed that except for the muscles of the right lower extremity, no other organs and tissues were involved. Conclusion:: ENKTCL confined to the muscle of the lower extremity is rare and often initially misdiagnosed as myositis because of red, swollen, heat, and painful symptoms that resemble inflammation, and in it, higher radiotracer uptake in 18F-FDG PET/CT helps to distinguish it from myositis.

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Section: Discussionmentioning

confidence: 96%

Section: Discussionmentioning

confidence: 99%

A Case of Nasal Extranodal NK/T-cell Lymphoma of Lower Limb Muscle Revealed by 18F-FDG PET/CT

Hu,

Li,

et al. 2024

CMIR

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“…In contrast with typical ENKTL, the immunohistochemical result of our case is relatively rare since CD56 was negative while CD20 was positive. Although CD56 is an important clue to diagnose NK/T cell lymphoma and is believed to be a marker for ENKTL, it has been infrequently reported to be negative in some cases, especially in cases with uncommon clinical manifestations (17). ENKTL with aberrant CD20 expression is extremely rare.…”

Section: Discussionmentioning

confidence: 99%

Case report: Mononeuropathy multiplex of extranodal natural killer/T-cell lymphoma misdiagnosed as systemic vasculitis

Shi,

Niu,

et al. 2023

Front. Neurol.

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BackgroundExtranodal NK/T-cell lymphoma (ENKTL) is an aggressive non-Hodgkin lymphoma that typically develops in the upper aerodigestive tract.Case presentationWe encountered an ENKTL patient who presented with purpura-like rashes and foot drops as initial symptoms and later developed other peripheral nerve involvement. The nerve conduction study of both the motor nerve and the sensory nerve showed axonal damage resembling mononeuropathy multiplex. Although the initial response to steroids was encouraging, the patient's symptoms reappeared and aggravated. A biopsy of the abdominal subcutaneous fat tissue with additional immunohistochemistry revealed neoplastic NK/T lymphocytes.ConclusionWe reported the first case presented as mononeuropathy multiplex as the initial clinical manifestation in ENKTL patients. Lymphoma should be considered in the diagnosis of atypical mononeuropathy in multiplex patients.

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“…5 Only a few cases of extranodal nasal-type NK/T-cell lymphoma invading muscle have been reported, but it is extremely rare for it to be confined to the muscles of the lower limbs. [6][7][8][9][10] Our case suggests that extranodal nasal-type NK/T-cell lymphoma should be considered as one of the differential diagnoses of primary muscle lesions, especially when presenting a high FDG uptake on PET/CT.…”

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confidence: 85%

Primary Extranodal Nasal-Type Natural Killer/T-Cell Lymphoma of Lower Limb Muscles on 18F-FDG PET/CT

Li,

2023

Clin Nucl Med

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Extranodal nasal-type natural killer/T-cell lymphoma may arise anywhere outside the lymph nodes, predominantly including the nasal cavity, nasopharynx, oropharynx, upper respiratory tract, gastrointestinal tract, skin, testes, and salivary glands, whereas primary tumor arising in muscle is rarely documented. We report FDG PET/CT findings of primary extranodal nasal-type natural killer/T-cell lymphoma in the muscles of the right lower limb in an 82-year-old man.

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Muscular involvement of extranodal natural killer/T cell lymphoma misdiagnosed as polymyositis: A case report and review of literature

Cited by 7 publications

References 17 publications

A Case of Nasal Extranodal NK/T-cell Lymphoma of Lower Limb Muscle Revealed by 18F-FDG PET/CT

A Case of Nasal Extranodal NK/T-cell Lymphoma of Lower Limb Muscle Revealed by 18F-FDG PET/CT

Case report: Mononeuropathy multiplex of extranodal natural killer/T-cell lymphoma misdiagnosed as systemic vasculitis

Primary Extranodal Nasal-Type Natural Killer/T-Cell Lymphoma of Lower Limb Muscles on 18F-FDG PET/CT

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