Bone cells might be considered in response to the distribution of nerves in the periosteum, epiphysis and bone marrow.The sensory and sympathetic neurotransmitters have trophic effects critically on normal osteogenic differentiation and bone metabolism in bone development and regeneration. It could modulate bone regeneration, bone remodeling, and articular cartilage homeostasis to their classic neurological actions. With touching and hearing mediated osseoperception, sensation can be adapted from the mechanical stimulation of a bone-anchored prosthesis. Investigations of the influence of music on the human brain showed structural and functional cerebro-neuroplasticity emerge as a result of long-term musical practice, which may cause cognitive differences between non-musicians and musicians. Meanwhile, the physical mechanical hits and touch strings and keys of instruments hypothetically were considered to cause adaptability for professional musicians in their peripheral tissues, especially bone sensation of fingers and correlated joints. Music practice is bone-strengthening activity. We hypothesis that it produces sensation adaptation in the fingers and correlated joints of instrument players, especially musicians after tremendous training and practice. Both the bone, correlated joint and its innervation are adapted by neuroplasticity for something part of “hardware constructing” to accomplish music performance. We thought that neuroplasticity occurred both in central nervous system and peripheral nervous system. Besides of developed in soft tissues of subcutaneous, connective tissue, muscle, inter-tissue coordination through neuro-network may occur in bone innervation coupled with correlated joint for specialized music-practice-oriented neuroplasticity. Soft tissues, such as muscle and tendon cannot directly hit instrument with stiffness to generate sound and rhythmic. Functionally, innervated-bone as bio-mechanical device becomes sensory musical target bone.