Musculoskeletal complications of neutron therapy for prostate cancer

Abstract

The purpose of this study was to investigate the cause of hip complaints following conformal neutron therapy delivered by opposed lateral and oblique anterior ports to treat prostate cancer. Twenty‐seven patients with hip complaints following neutron or mixed neutron and photon therapy for prostate cancer had 34 magnetic resonance imaging (MRI) studies 3–39 (mean 15.3) months following treatment; for comparison, 13 similarly treated patients without hip complaints were imaged 1–32 (mean 13.8) months post‐treatment; 25/40 imaged patients received concurrent nonsteroidal hormone therapy. Coronal and axial images of the hips/pelvis were obtained utilizing T1 weighted spin echo and fat suppressed inversion recovery (STIR) sequences. Signal amplitude (SA) of involved muscles was measured on the STIR images and normalized to that of the psoas outside the treatment field. Hip complaints ranged from mild soreness or motion limitation to severe pain and limitation of ambulation; presence and severity of symptoms (sx) were significantly related to neutron dose (P = 0.020 and 0.0001) but not to hormone therapy (each P > 0.17). Normalized SA of the obturator muscles differed significantly with neutron dose (P = 0.013), the presence, and the severity, of sx (P = 0.0002 and 0.0007); estimated extent of abnormal muscle also differed significantly with neutron dose (P = 0.039), presence, and severity, of sx (P = 0.00004 and 0.0007); [hormone treatment had a profound effect on SA (P = 0.0001) and extent (P = 0.005) which was independent of sx (P = 0.10 and 0.14, respectively) and neutron dose (P = 0.33 and 0.32, respectively)]. Subcutaneous changes localized lateral to the greater trochanter were seen in all, and edema of the subjacent gluteus muscles in many, symptomatic hips; only 4/13 asymptomatic hips showed subcutaneous changes, 6 had mild gluteus edema. Avascular necrosis of the femoral head was seen in 5 symptomatic hips, with marked acetabular necrosis in 3 of these; small joint effusions were seen in 8 symptomatic hips; asymptomatic hips had no significant bone or joint abnormalities. Neutron therapy for prostate cancer designed to spare the rectum results in significant dose‐dependent, musculoskeletal complications which are well demonstrated by MRI. SA abnormalities of irradiated muscle correlate significantly with neutron dose and both presence and severity of hip sx. Protocol modifications have been implemented to reduce these complications. MRI provides an objective means to assess both complications and the success of new protocols in ameliorating them. Concurrent hormone therapy has a profound effect on muscle changes on MRI which is independent of neutron dose and sx. Radiat. Oncol. Invest. 5:81–91, 1997. © 1997 Wiley‐Liss, Inc.

Changes in shoulder muscle size and activity following treatment for breast cancer

“…Radiation injury to normal tissues is believed to be nonspecific and generally to produce no pathognomic changes [5]. However, the combined changes in the parenchyma and vascular tissues [6,7] are thought to characterise the radiation damage to healthy tissues. Changes in the vascular network are thought to cause muscle ischaemia whilst a limited ability to expand, due to connective tissue constraints, is believed to have an effect on the efficacy of muscle contraction [8][9][10].…”

“…Most studies have found axillary radiation to be a prognostic factor for the development of shoulder morbidity [3,4,11]. Soft tissue changes have been seen from the onset of radiotherapy (dose dependent) to as late as 3 years after the start of radiotherapy [6,7]. MRI studies have shown radiation induced muscle morbidity in cervical cancer [9] and prostate cancer [7].…”

“…Soft tissue changes have been seen from the onset of radiotherapy (dose dependent) to as late as 3 years after the start of radiotherapy [6,7]. MRI studies have shown radiation induced muscle morbidity in cervical cancer [9] and prostate cancer [7]. In breast cancer only clinical observations have been reported for muscle morbidity of pectoralis major [6,10], serratus anterior and lattissimus dorsi [12].…”

Changes in Pectoral Muscle Volume During Subacute Period after Radiation Therapy for Breast Cancer: A Retrospective up to 4-year Follow-up Study

“…Muscle changes were mostly observed after 3 years at the latest after RT 17,18 . In breast cancer, clinical findings have been reported on muscle morbidity of the pectoralis major 17,19 .…”