Background Musculoskeletal disorders are injuries or dysfunctions affecting muscles, bones, nerves, tendons, ligaments, joints, cartilages, and spinal discs. Musculoskeletal disorders include sprains, strains, tears, soreness, pain, carpal tunnel syndrome, hernias, and connective tissue injuries of the structures previously mentioned. There is a scarcity of literature regarding musculoskeletal (MSDs) on porters including prevalence of musculoskeletal (MSDs), personal factors that can lead to musculoskeletal (MSDs) and ergonomic factors which should workers be exposed to the risk for the development of musculoskeletal (MSDs).Methodology A cross- sectional study design was used, and questionnaire has been employed as data collection instruments. The sample size was 114 individuals. The study used probability sampling with stratified random sampling technique where each person in the people has an equivalent opportunity of being included in the sample. Multivariate analysis was involved in data analysis for factor factors associated with musculoskeletal (MSDs) with 95% level of confidence Interval and P value of 0.05.Results The results showed a proportion of 68.2% for musculoskeletal (MSDs) prevalence. The knowledge of different types of musculoskeletal (MSDs) showed that the most known musculoskeletal disorders types was Sprains, strains, and tears. Lifting heavy luggage is 0.9 times less likely of developing musculoskeletal (MSDs) than those who not lifting heavy luggage with (OR:0.9; CI: 0.2–2.4), having much regular working hours is 0.9 times less likely of developing musculoskeletal (MSDs) than those who have less regular working hours with (OR:0.9; CI: 0.2–2.4), and being single is 1.63 times more likely associated with the risk of developing musculoskeletal (MSDs) than those who are married/separated or divorced with (OR:1.63, CI 0.72–1.77).Conclusion The study concluded that factors such as not lifting heavy luggage, less experience and much regular working hours are the protective factors for musculoskeletal (MSDs) while being single and having less weight are the associated factors with musculoskeletal (MSDs).