Musculoskeletal disorders in hemodialysis patients: different disease clustering according to age and dialysis vintage

Hage, Sandrine; Hage, Valérie; El-Khoury, Nathalie; Azar, Hiba; Chelala, Dania; Ziadé, Nelly

doi:10.1007/s10067-019-04786-w

Cited by 22 publications

(30 citation statements)

References 23 publications

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“…On the other hand, the results of this study were lower than a study done in Beirut, Lebanon, which found a prevalence of MSDs, of 76.4%. 31 This observed difference could be related to be difference in eligibility criteria; in the Lebanon study, all of the participants were stage V chronic kidney disease patients, which has been a positive correlation with MSDs. 32 This discrepancy could be due to the adoption of differing definitions for musculoskeletal illnesses; in the Lebanon study, MSDs were classified according to predetermined diagnostic criteria.…”

Section: Discussionmentioning

confidence: 97%

“…This result had shown difference with the study done in Taiwan, Lebanon and Ankara turkey. 25 , 33 , 36 This difference might be the number of patients having MSDs and HTN can be varied in the studies, sample size difference and difference in eligibility criteria might be the potential reasons.…”

Section: Discussionmentioning

confidence: 99%

“…This result is supported by studies done in Lebanon (AOR=1.04; P=0.04), Spain (AOR=1.31; P<0.00) and also study in Canada. [29][30][31] This similarity can be explained by with ageing musculoskeletal tissue had increased risk of bone fragility, a decrease in ligament elasticity, a decreased muscular strength and function and a loss in cartilage resilience. This will affect the tissue not to perform their normal function.…”

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confidence: 96%

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Musculoskeletal Disorders and Associated Factors Among Patients with Chronic Kidney Disease Attending at Saint Paul Hospital, Addis Ababa, Ethiopia

Deme¹,

Fisseha²,

Kahsay³

et al. 2021

IJNRD

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Background Musculoskeletal disorders contributed from chronic kidney disease are increasing worldwide. Musculoskeletal disorders had a significant health burden and are leading causes of co-morbidities, disability and low productivity, which potentially affect individual’s functional status and quality of life. Purpose The aim of this study was to assess the prevalence of musculoskeletal disorders and its associated factors among patients with chronic kidney attending in Saint Paul Hospital, Addis Ababa, Ethiopia. Patients and Methods An institution-based cross-sectional study was conducted on 302 enrolled study participants through systematic random sampling techniques. Face-to-face interview, physical examination and chart reviews were used to collect data using semi-structured questionnaire adapted from a standard Nordic Musculoskeletal Questionnaire and other literatures. Data were entered into Epi Info version 7 and exported to SPSS version 23 for analysis. Bivariate logistic regression analysis was employed with a p-value less than 0.25. Finally, those variables having a p-value less than 0.05 with 95% CI in multivariate analysis were taken as statistically significant. Results The prevalence of musculoskeletal disorders among CKD individuals was found to be 58.6% (95% CI; 53.0, 64.1). Being female (AOR = 0.49; 95% CI 0.26, 0.94), age between 40 and 49 (AOR = 3.34; 95% CI 1.07, 10.44), stage III (AOR = 0.24; 95% CI 0.06, 0.89) and stage IV (AOR = 0.24; 95% CI 0.06, 0.89) chronic kidney disease, having HTN (AOR = 7.47; 95% CI 3.47, 16.06), parathyroid hormone level ≥100 pg/mL (AOR = 0.43; 95% CI 0.21, 0.87), calcium level <8.4 mg/dl (AOR = 5.89; 95% CI 2.66, 13.56) and serum 25 hydroxy vitamin D level <20 ng/mL (AOR = 3.91; 95% CI 1.32, 11.56) were significantly associated with musculoskeletal disorders. Conclusion MSDs were shown to be moderately common in CKD patients. Female gender, age between 40 and 49 yrs, stage III and stage IV CKD, hypertension, higher PTH level, lower calcium level and lower vitamin D level were statistically significant in their association with musculoskeletal disorders.

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Section: Discussionmentioning

confidence: 97%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 96%

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Musculoskeletal Disorders and Associated Factors Among Patients with Chronic Kidney Disease Attending at Saint Paul Hospital, Addis Ababa, Ethiopia

Deme¹,

Fisseha²,

Kahsay³

et al. 2021

IJNRD

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“…Pain in these patients could manifest as myalgia, cramps, headache, musculoskeletal pain, neuropathic pain, and/or chest pain [ 10 , 11 ]. In addition, bone pain and progressive loss of muscle mass can also affect the quality of life of these patients [ 12 , 13 , 14 ].…”

Section: Introductionmentioning

confidence: 99%

Pain in Hemodialysis Patients: Prevalence, Intensity, Location, and Functional Interference in Daily Activities

et al. 2021

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Although pain is a frequent complaint of patients with chronic kidney disease who undergo hemodialysis, few studies have assessed the functional interference of pain in activities of daily living (ADLs). Hence, the aim of this study was to evaluate the prevalence, location, intensity, and functional interference of pain in ADLs of chronic kidney disease patients undergoing hemodialysis and to estimate the association of specific pain sites with severe functional interference by pain in ADLs. This cross-sectional study included patients with chronic kidney disease undergoing hemodialysis. The prevalence, intensity, and functional interference of pain in ADLs were assessed using the brief pain inventory. Poisson regression was used to calculate the prevalence ratio. A total of 65 patients participated in the study. The overall prevalence of pain was 89.23%; the prevalence of headache was 18.46% and that of pain in the trunk was 55.38%, upper limbs was 35.38%, and lower limbs was 60.00%. The prevalence of moderate and severe pain at the time of hemodialysis was 13.85% and 21.54%, respectively. A high prevalence of severe functional interference of pain in general activity (61.54%), mobility (56.92%), and disposition (55.38%) was observed. Pain is a frequent complaint in patients undergoing hemodialysis, mainly musculoskeletal and intradialytic, and it interferes with ADLs and incapacitates the patient. Pain was highly prevalent in the upper and lower limbs and the trunk. Furthermore, a higher prevalence of severe pain at the time of hemodialysis and functional interference of pain, mainly in general activity, mobility, and disposition, were observed.

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“…The prevalence of grade III or IV osteoarthritis (OA) in CKD patients aged 15–64 years (9.4%) was three times greater than in the normal population (3.0%). In hemodialysis patients, the incidence of OA is high (53.9%) and localized in all joints including the knee joint (24.7%) 5 – 7 . Moreover, the chronic musculoskeletal pain associated with CKD has mechanisms that are multi-factorial in nature 8 .…”

Section: Introductionmentioning

confidence: 99%

Hypoperfusion of the infrapatellar fat pad and its relationship to MRI T2* relaxation time changes in a 5/6 nephrectomy model

Huang

Peng

Hsu

et al. 2021

Sci Rep

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The purpose of present study was to longitudinally investigate the alterations in infrapatellar fat pad (IPFP) vascularity in 5/6 nephrectomized rats by using dynamic contrast enhanced (DCE) MRI and IPFP degeneration by using MRI T2* relaxation time. Twelve male Sprague–Dawley rats were assigned to a control group and a 5/6 nephrectomy CKD group. The right knees of all rats were longitudinally scanned by 4.7 T MRI, and serial changes in the IPFP were assessed at 0, 8, 16, 30, and 44 weeks by DCE-MRI (parameters A, kel and kep) and MRI T2* mapping. After MRI measurements, knee specimens were obtained and evaluated histologically. The CKD group had IPFPs with lower blood volume A and lower permeability kep values from 16 weeks (p < 0.05), lower venous washout kel value from 30 weeks (p < 0.001), and significantly higher T2* values reflecting adipocyte degeneration beginning at 16 weeks (p < 0.05). The histopathological results confirmed the MRI findings. Hypoperfusion and adipocytes degeneration related to CKD were demonstrated in a rodent 5/6 nephrectomy model. DCE parameters and MRI T2* can serve as imaging biomarkers of fat pad degeneration during CKD progression.

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Musculoskeletal disorders in hemodialysis patients: different disease clustering according to age and dialysis vintage

Cited by 22 publications

References 23 publications

Musculoskeletal Disorders and Associated Factors Among Patients with Chronic Kidney Disease Attending at Saint Paul Hospital, Addis Ababa, Ethiopia

Musculoskeletal Disorders and Associated Factors Among Patients with Chronic Kidney Disease Attending at Saint Paul Hospital, Addis Ababa, Ethiopia

Pain in Hemodialysis Patients: Prevalence, Intensity, Location, and Functional Interference in Daily Activities

Hypoperfusion of the infrapatellar fat pad and its relationship to MRI T2* relaxation time changes in a 5/6 nephrectomy model

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