Musculoskeletal Health of the Adults Over 50 Years of Age in Relation to Antioxidant Vitamin Intakes

Kim, Namhee; Kang, Yeji; Choi, Yong Jun; Lee, Yunhwan; Park, Seok Jun; Park, Hyoung Su; Kwon, Miyoung; Chung, Yoon‐Sok; Park, Yoo Kyoung

doi:10.7762/cnr.2022.11.2.84

Cited by 2 publications

(1 citation statement)

References 43 publications

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“…The protective effect of dried fruit intake on low back pain might be related to the micronutrients and bioactive compounds dried fruits contain. For instance, vitamin E could improve musculoskeletal health by maintaining bone mineral density and reducing oxidative stress and inflammation ( 38 , 39 ). In addition, some authors found that flavonoids had antioxidant and antinociceptive activities, which may be used to relieve pain ( 40 , 41 ).…”

Section: Discussionmentioning

confidence: 99%

Dried fruit intake causally protects against low back pain: A Mendelian randomization study

Huang

Xie

2023

Front. Nutr.

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BackgroundLow back pain is the leading cause of years lived with disability worldwide. The aim of this study was to evaluate whether dried fruit intake causally protects against low back pain using two-sample Mendelian randomization (MR).MethodsWe obtained summary-level data for dried fruit intake (N = 421,764) from the IEU Open GWAS Project. Forty-one independent genetic variants proxied dried fruit intake. The corresponding data for low back pain were derived from the FinnGen project (13,178 cases and 164,682 controls; discovery data) and the Neale lab (5,423 cases and 355,771 controls; replication data). We conducted univariable and multivariable MR analyses.ResultsIn the univariable MR analysis, the inverse variance weighted estimate showed that greater dried fruit intake was associated with decreased risk of low back pain [odds ratio (OR) = 0.435, 95% confidence interval (CI): 0.287–0.659, P = 8.657 × 10−5]. Sensitivity analyses using the MR-Egger (OR = 0.078, 95% CI: 0.013–0.479, P = 0.009), maximum likelihood (OR = 0.433, 95% CI: 0.295–0.635, P = 1.801 × 10−5), weighted median (OR = 0.561, 95% CI: 0.325–0.967, P = 0.038) and Mendelian Randomization Pleiotropy RESidual Sum and Outlier (MR-PRESSO) (OR = 0.454, 95% CI: 0.302–0.683, P = 4.535 × 10−4) methods showed consistent results. No evidence of directional pleiotropy was identified according to the Egger intercept (intercept P-value = 0.065) or applying the MR-PRESSO method (global test P-value = 0.164). The replication analysis yielded similar results. The multivariable MR revealed that the inverse association between dried fruit intake and low back pain was consistent after adjustment for fresh fruit intake, body mass index, current tobacco smoking, alcohol intake frequency, total body bone mineral density, serum 25-hydroxyvitamin D levels, and vigorous physical activity.ConclusionThis MR study provides evidence to support that dried fruit intake causally protects against low back pain.

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Section: Discussionmentioning

confidence: 99%

Dried fruit intake causally protects against low back pain: A Mendelian randomization study

Huang

Xie

2023

Front. Nutr.

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Plant-Based Diets and Their Associations with Physical Performance in the Baltimore Longitudinal Study of Aging

Bigman,

Rusu,

Kleckner

et al. 2024

Nutrients

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Background: Plant-based diets are associated with various health benefits; however, their impact on physical performance in aging populations remains unclear. Objectives: To investigate the associations between adherence to plant-based diets and physical performance, focusing on their potential protective effects against age-related declines in function. Methods: Data were obtained from men and women aged 40 years or older in the Baltimore Longitudinal Study of Aging (BLSA) (mean ± SD age: 68 ± 13 years at the first dietary visit; n = 1389). Dietary intake was assessed using a food frequency questionnaire (FFQ). Plant-based diets, calculated from 18 food groups, were categorized as overall (PDI), healthful (hPDI), or unhealthful (uPDI), and their tertiles across visits were analyzed. Multivariable linear mixed-effects models were used to examine the association between repeated measurements of three physical performance outcomes—Short Physical Performance Battery (SPPB), grip strength (kg), and gait speed (m/s)—and adherence to each plant-based diet. Results: In fully adjusted models, SPPB and grip strength were significantly associated with both hPDI and uPDI, but not with PDI. For hPDI, the intermediate tertile showed the greatest benefit, with SPPB scores 0.5 points higher (βT2vs.T1 = 0.50, 95% CI: 0.30–0.70, p < 0.001) over the follow-up period. In contrast, for uPDI, a 0.27-point lower SPPB score was seen (βT3vs.T1 = −0.27, 95% CI: −0.48 to −0.07, p = 0.009). Longitudinally, grip strength was positively associated with hPDI (βT3vs.T1 = 1.14, 95% CI: 0.24–2.05, p = 0.0013). Similar results were observed in older adults aged ≥65 years. Conclusions: Adherence to hPDI may benefit lower body function and muscle strength, while uPDI appears to have adverse effects. This suggests that the quality of plant-based foods is essential for maintaining functional well-being in older adults. Further research is needed to confirm these findings, explore underlying mechanisms, and identify strategies to optimize plant-based dietary patterns for aging populations.

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Musculoskeletal Health of the Adults Over 50 Years of Age in Relation to Antioxidant Vitamin Intakes

Cited by 2 publications

References 43 publications

Dried fruit intake causally protects against low back pain: A Mendelian randomization study

Dried fruit intake causally protects against low back pain: A Mendelian randomization study

Plant-Based Diets and Their Associations with Physical Performance in the Baltimore Longitudinal Study of Aging

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