The article is devoted to the mechanisms of action and effectiveness of the original technology, combining the blockade in accordance with Vishnevsky method and pharmacopuncture with the drug Alflutop.Materials and methods. 90 patients under 65 years of age with exacerbation of lumbosacral dorsopathy, who signed informed consent form were inсluded in observation. Along with clinical characteristics, the results of psychological tests, thermography and zonal rheovasography were evaluated. Patients were divided into 3 groups in which standard treatment was performed. In the 1st control group, they were limited to it, and in others, local stimulation was additionally performed. Methodically, up to 20 loci in the lumbar zone and 6–8 reflexology points in the lower extremities were selected. At the same time, the anesthetic Lidocaine was injected into the points of the lumbar zone, and the drug Alflutop (2nd group) or physiological solution (3rd) was injected into the distal points. The course of stimulation included 10 procedures performed every other day.Outcomes. Both variants of local stimulation significantly exceeded the effectiveness of basic therapy. However, despite the comparability of the rate of pain symptomatics reduction in these groups, the final level of pain was significantly lower in the case of Alflutop. These data were consistent with a clear tendency to normalize the mental and vascular background in patients of the 2nd group. This phenomenon can be explained by the points of application of medicines: rapid anesthesia due to blockade by anesthetic and the maximum effectiveness provided by pharmacopuncture.