Musculoskeletal pain in adults born preterm: Evidence from two birth cohort studies

Evensen, Kari Anne I.; Tikanmäki, Marjaana; Heinonen, Kati; Matinolli, Hanna‐Maria; Sipola-Leppänen, Marika; Lano, Aulikki; Wolke, Dieter; Vääräsmäki, Marja; Eriksson, Johan G.; Andersson, Sture; Järvelin, Marjo‐Riitta; Hovi, Petteri; Räikkönen, Katri; Kajantie, Eero

doi:10.1002/ejp.1320

Cited by 3 publications

(2 citation statements)

References 52 publications

(130 reference statements)

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“…Studies have linked migraine to musculoskeletal symptoms (41) and dysfunctions (42). However, there is no clear association between gestational age and musculoskeletal pain: One cohort study reported an association between preterm birth and chronic pain (43), but other larger studies found no association between preterm birth and chronic pain in adolescents (44) or widespread musculoskeletal pain in young adults (45). With this background, the lack of association between gestational age and migraine in our study may not be unexpected.…”

Section: Discussionmentioning

confidence: 99%

Migraine in children and adults born preterm: A nationwide register linkage study

et al. 2020

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Objective Being born preterm is related to adverse health effects later in life. We studied whether preterm birth predicts the risk of migraine. Methods In this nationwide register study, we linked data from six administrative registers for all 235,624 children live-born in Finland (January 1987 to September 1990) and recorded in the Finnish Medical Birth Register. n = 228,610 (97.0%) had adequate data and were included. Migraine served as primary outcome variable and was stringently defined as a diagnosis from specialised health care and/or ≥2 reimbursed purchases of triptans. We applied sex- and birth year-stratified Cox proportional hazard regression models to compute hazard ratios and confidence intervals (95% confidence intervals) for the association between preterm categories and migraine. The cohort was followed up until an average age of 25.1 years (range: 23.3–27.0). Results Among individuals born extremely preterm (23–27 completed weeks of gestation), the adjusted hazard ratios for migraine was 0.55 (0.25–1.24) when compared with the full-term reference group (39–41 weeks). The corresponding adjusted hazard ratios and 95% confidence intervals for the other preterm categories were: Very preterm (28–31 weeks); 0.95 (0.68–1.31), moderately preterm (32–33 weeks); 0.96 (0.73–1.27), late preterm (34–36 weeks); 1.01 (0.91–1.11), early term (37–38 weeks); 0.98 (0.93–1.03), and post term (42 weeks); 0.98 (0.89–1.08). Migraine was predicted by parental migraine, lower socioeconomic position, maternal hypertensive disorder and maternal smoking during pregnancy. Conclusion We found no evidence for a higher risk of migraine among individuals born preterm.

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Section: Discussionmentioning

confidence: 99%

Migraine in children and adults born preterm: A nationwide register linkage study

et al. 2020

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“…Evaluating associations between preterm birth, neonatal experience and the incidence of chronic pain in later life are hampered by differences in patient populations, definition of chronic pain, methodology and outcome [14,[18][19][20][21](Table 1). In addition, differentiating persistent biological effects related to neonatal exposures, and subsequent modulation by psychosocial and environmental factors, becomes more difficult at older ages [22].…”

Section: Pain Report and Experience In Young Adultsmentioning

confidence: 99%

Early life pain—effects in the adult

Walker

2019

Current Opinion in Physiology

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Early life stress and injury can have long-term effects on nociceptive processing and the risk of persistent pain in later life. Neonates requiring prolonged intensive care, particularly those born extremely preterm, are at risk due both to immaturity at birth and exposure to tissue injury and pain from procedural interventions and surgery. This review will summarise clinical evaluations of pain experience and somatosensory function in preterm-born young adults; and highlight data from laboratory studies evaluating the potential for tissue injury in neonatal rodents to prime nociceptive processing and alter the response to subsequent injury in adulthood.

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The relation between preterm birth and self-reported spinal pain in pre-adolescence—a study of 47,063 subjects from the Danish National Birth Cohort

Kaltoft,

Nielsen,

Andersen

et al. 2023

Eur J Pediatr

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Repeated exposure to pain and stress in early life may cause alterations in pain sensitivity later in life. Children born preterm are often exposed to painful invasive procedures. This study aimed to explore the relationship between being born preterm and self-report of spinal pain in pre-adolescence. This prospective study was based on the Danish National Birth Cohort and consisted of 47,063 11–14-year-olds. Data from the Danish National Birth Cohort were linked with national registers through Statistics Denmark. Analyses were performed as multiple logistic regression models estimating odds ratios and 95% confidence intervals. Spinal pain (neck, mid back, and/or low back pain) was assessed using a subdivision of the Young Spine Questionnaire. Severe spinal pain was defined as having pain often or once in a while with an intensity of four to six on the Revised Faces Pain Scale. Inverse probability weighting was used to account for potential selection bias. Girls born very preterm (< 34 full weeks of gestation) were less likely to report spinal pain (OR: 0.60; 95% CI: 0.40–0.93) compared with those term-born. The associations were weaker when examining moderate to severe spinal pain and when examining the three spinal regions separately. None of these was statistically significant.Conclusion: We found no associations for boys. In conclusion, this study indicates that girls born very preterm are seemingly less likely to have severe spinal pain in pre-adolescence than girls born at term. What is Known:• Spinal pain is one of the largest disease burdens globally, and the evidence regarding the etiology of spinal pain in children and adolescents is limited.• Repeated exposure to pain and stress in early life (i.e., being preterm) may cause alterations in pain sensitivity later in life. What is New:• Girls born very preterm (< 34 full weeks of gestation) seem less likely to report severe spinal pain in pre-adolescence compared with girls born at full term.• There is no association between gestational age and later experience of spinal pain in pre-adolescent boys.

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Musculoskeletal pain in adults born preterm: Evidence from two birth cohort studies

Cited by 3 publications

References 52 publications

Migraine in children and adults born preterm: A nationwide register linkage study

Migraine in children and adults born preterm: A nationwide register linkage study

Early life pain—effects in the adult

The relation between preterm birth and self-reported spinal pain in pre-adolescence—a study of 47,063 subjects from the Danish National Birth Cohort

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