Musculoskeletal Disorders (MSDs) are a group of medical conditions that affect the musculoskeletal systems, which include muscles, tendons, ligaments, and nerves, that support the body and allow movement. In the context of workers in the unorganized sector, due to the nature of their profession, MSDs are expected, which often involve repetitive motions, heavy lifting, awkward postures, and other physical demands. Loss of money, decreased productivity, and a decline in quality of life are all possible consequences for the workers. Therefore, it is crucial to prevent and manage MSD among workers in the unorganized sector such as improving working conditions, providing training on safe work practices, and promoting early detection and treatment of MSD. The study aims to identify the variables that affect informal worker’s quality of life. The researcher gathered the available data and suggested a few guidelines. The condition of employees may be improved with certain adjustments to the workplace, work tools, worker health, work duties, and work management.