Musculosketal Symptoms and Non-REM Sleep Disturbance in Patients with “Fibrositis Syndrome” and Healthy Subjects

Moldofsky, Harvey; Scarisbrick, Phillip; England, Robert W.; Smythe, H A

doi:10.1097/00006842-197507000-00008

Cited by 761 publications

(142 citation statements)

References 14 publications

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“…Several researchers conducted PSG in order to explore physiological foundations of poor sleep quality in patients with fibromyalgia experience. 25,26 In their study, Drewes et al 27 discovered various changes 31 demonstrated in their study that sleep disorder, waking up unrefreshed and PSG changes, which occur in FMS, might also occur in patients with OSAS.…”

Section: Discussionmentioning

confidence: 99%

Decrease of Serum IGF-1 Level is Not Associated With Obstructive Sleep Apnea in Fibromyalgia Patients

Hayta

Oksasoglu

2017

Arch Rheumatol

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Objectives: This study aims to investigate the relationship of serum insulin-like growth factor 1 (IGF-1) level with obstructive sleep apnea, the Pittsburgh sleep quality index (PSQI), age, body mass index, and fibromyalgia impact questionnaire (FIQ) in fibromyalgia syndrome (FMS) patients. Patients and methods: A total of 105 female patients (mean age 41.8±9.0 years; range 26 to 55 years) with fibromyalgia (FMS group) who were diagnosed according to 2010 American College of Rheumatology criteria, and 51 female patients (mean age 39.9±10.8 years; range 24 to 54 years) with mechanical low back pain (MLBP) (control group) were included in the study. Age, smoking, educational status, tender point number, body mass index, duration of disease, FIQ, PSQI, and polysomnographic assessment of both FMS and control groups were recorded. Results: Sleep disorder was detected in 88 patients in FMS group and 15 patients in control group (p<0.05). The PSQI score was higher in the FMS group compared to the control group (9.9±4.6 vs 5.7±3.5). The FIQ score was higher in the FMS group compared to the control group (53.4±17.4 vs 26.4±13.9; p<0.05). The serum IGF-1 level of FMS group was significantly lower than that of the control group (140.6±49.5 ng/mL vs 177.2±58.5 ng/mL; p<0.05). In the FMS group, an examination of the correlation between serum IGF-1 level with the age, body mass index, obstructive sleep apnea syndrome, FIQ, and PSQI revealed a negative correlation between serum IGF-1 with the age and PSQI. The obstructive sleep apnea syndrome ratios of study groups were comparable with regard to the frequencies of mild, moderate, and severe obstructive sleep apnea syndrome. Conclusion: In FMS patients, serum IGF-1 levels may decrease due to age and PSQI; however, this may not be related to the severity of obstructive sleep apnea.

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Section: Discussionmentioning

confidence: 99%

Decrease of Serum IGF-1 Level is Not Associated With Obstructive Sleep Apnea in Fibromyalgia Patients

Hayta

Oksasoglu

2017

Arch Rheumatol

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“…In patients with FMS, impairment of especially NREM stage of sleep is seen [24]. First, in the year 1975, PSG reports indicated the presence of alpha intrusions in NREM deep sleep in patients with FMS [25].…”

Section: Discussionmentioning

confidence: 99%

“…Patients with AHI of ≥5 events/h were diagnosed with OSAS. Based on their AHI scores, the patients were categorized into mild (AHI, 5-15), moderate (AHI, [15][16][17][18][19][20][21][22][23][24][25][26][27][28][29][30], and severe OSAS (AHI, >30) groups according to the AASM Task Force criteria [11]. Oxygen desaturation index (ODI) was defined as the total number of measurements of oxyhemoglobin desaturation of ≥4% within ≥10 s-<3 min from the baseline divided by the total sleep time.…”

Section: Psg Evaluationmentioning

confidence: 99%

Is There a Link Between Obstructive Sleep Apnea Syndrome and Fibromyalgia Syndrome?

et al. 2017

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OBJECTIVES:Fibromyalgia syndrome (FMS) is characterized by complaints of chronic musculoskeletal pain, fatigue, and difficulty in falling asleep. Obstructive sleep apnea syndrome (OSAS) is associated with symptoms, such as morning fatigueness and unrefreshing sleep. We aimed to investigate the presence of OSAS and objectively demonstrate changes in sleep pattern in patients with FMS. MATERIAL AND METHODS:Polysomnographic investigations were performed on 24 patients with FMS. Patients were divided into two groups: patients with and without OSAS (Group 1 and Group 2, respectively). A total of 40 patients without FMS who presented to the sleep disorders polyclinic with an initial diagnosis of OSAS were included in Group 3. Based on their apnea hypopnea index (AHI), OSAS in the patients were categorized as mild (AHI,(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15), moderate (30), or severe (>30). RESULTS:OSAS was detected in 50% of patients with FMS. The most prominent clinical findings were morning fatigue and sleep disorder, which were similar in three groups. In polysomnography (PSG) evaluation, patients with FMS had mild (33%), moderate (25%), and severe (42%) OSAS. In correlation analyses, negative correlations were observed between fibromyalgia impact questionnaire (FIQ) and mean oxygen saturation, visual analogue scale (VAS), and minimum oxygen saturation, whereas a positive correlation was found between FIQ and desaturation times in patients with FMS. CONCLUSION:Detection of OSAS in 50% of the patients with FMS, and similar rates of complaints of sleep disorder and morning fatigue of OSAS and FMS cases are important results. Detection of correlation between the severity of hypoxemia and FIQ and VAS scores are significant because it signifies the contribution of increased tissue hypoxemia to the deterioration of clinical status. Diagnosis and treatment of OSAS associated with FMS are important because of their favorable contributions to the improvement of the clinical picture of FMS. KEYWORDS:Obstructive sleep apnea syndrome, fibromyalgia syndrome, polysomnography, sleep disorders, apnea hypopnea index, hypoxemia INTRODUCTIONFibromyalgia syndrome (FMS) is a chronic health problem that presents with pain all over the body, with other symptoms, such as tenderness of the affected joints, muscles fatigue, sleep problems (waking up unrefreshed and excessive daytime sleepiness), and cognitive impairment [1]. Since its etiology is not fully known, its treatment is symptomatic. Patients with FMS are usually treated with various combinations of physiotherapy, psychotherapy, psychotrophic drugs, and analgesics. Treatment effectiveness in FMS is limited, and these patients frequently lead their lives with symptoms of chronic insomnia, sleep problems, fatigue, and pain [2].Obstructive sleep apnea syndrome (OSAS) is a pathology with systemic effects that are characterized by associated symptoms of recurrent episodes of upper respiratory tract obstruction, hypoxemia, arousals during sleep, morning fatigue because of impaired sleep ...

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“…Poor sleep may aggravate pain and may also contribute to disturbed sleep. There is a relationship, in fact, between poor sleep and pain, and sleep disturbances are important in the genesis of tender points (37,38). Loss of deeper phases of sleep (stages three and four) is characteristic of FM and leads to the loss of restorative feelings on awakening.…”

Section: Sleep Dysfunctionmentioning

confidence: 99%

Symptoms and signs in fibromyalgia syndrome

Cassisi¹,

Sarzi-Puttini²,

Alciati³

et al. 2011

Reumatismo

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Musculosketal Symptoms and Non-REM Sleep Disturbance in Patients with “Fibrositis Syndrome” and Healthy Subjects

Cited by 761 publications

References 14 publications

Decrease of Serum IGF-1 Level is Not Associated With Obstructive Sleep Apnea in Fibromyalgia Patients

Decrease of Serum IGF-1 Level is Not Associated With Obstructive Sleep Apnea in Fibromyalgia Patients

Is There a Link Between Obstructive Sleep Apnea Syndrome and Fibromyalgia Syndrome?

Symptoms and signs in fibromyalgia syndrome

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