Mushroom-derived polysaccharides as antitumor and anticancer agent: A concise review

Hyder, Salman M.; Dutta, Sayan Deb

doi:10.1016/j.bcab.2021.102085

Cited by 27 publications

(11 citation statements)

References 119 publications

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“…Mushrooms are widely cultivated worldwide due to their high nutritional value and medicinal properties [ 1 , 2 ]. The cultivation of mushrooms improves their ecological value, promotes sustainable use and helps the conservation of the environment [ 3 ].…”

Section: Introductionmentioning

confidence: 99%

Lentinula edodes, a Novel Source of Polysaccharides with Antioxidant Power

2022

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The fruiting bodies of edible mushrooms represent an important source of biologically active polysaccharides. In this study, Lentinula edodes crude polysaccharides (LECP) were extracted in hot water, and their antioxidant and antiradical activities were investigated. The antioxidant activity of LECP was investigated against reactive species such as 1,1’-diphenyl-2-picrylhydrazyl, 2,2’-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid, hydroxyl and superoxide anion radicals, reducing power with EC50 values of 0.51, 0.52, 2.19, 3.59 and 1.73 mg/mL, respectively. Likewise, LECP inhibited the lipid peroxidation induced in methyl linoleate through the formation of conjugated diene hydroperoxide and malondialdehyde. The main sugar composition of LECP includes mannose, galactose, glucose, fucose and glucuronic acid. Characterization by Fourier transform infrared spectroscopy and nuclear magnetic resonance determined that LECP was made up of α and β glycosidic bonds with a backbone of α-D-Glc, →6)-β-D-Glcp-(1→, →6)-α-D-Galp-(1→ and β-D-Manp-(1→ residues. The results showed that LECP can scavenge all reactive species tested in a concentration-dependent manner and with a protective effect in the initial and final stages of lipid peroxidation. The natural antioxidant activity of the LECP that was investigated strengthens the high medicinal and nutritional value of this mushroom.

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Section: Introductionmentioning

confidence: 99%

Lentinula edodes, a Novel Source of Polysaccharides with Antioxidant Power

2022

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“…H. coralloides EPS has anti-proliferative activities on cancer cell lines and decreased viability of the cancer AGS and MKN-45 cells more than 80 and 70%, respectively, after 48 h of the treatment. Earlier studies showed strong anti-cancer potential of the polysaccharides of the genus Hericium [ 52 ]. β-Glucans can bind to specific receptors to activate macrophages, dendritic cells, neutrophils, and monocytes, and stimulate humoral and cellular immunity.…”

Section: Discussionmentioning

confidence: 99%

“…Aqueous extract of H. erinaceus reduced the formation of tumor nodules in the lungs almost twice [ 59 ]. Studies showed that H. erinaceus polysaccharides prevented migration of the cancer cells [ 52 ]. Our results as well as already-published data indicated that Hericium polysaccharides have strong antitumor activity.…”

Section: Discussionmentioning

confidence: 99%

Antioxidant activity and cytotoxicity of exopolysaccharide from mushroom Hericium coralloides in submerged fermentation

Tabibzadeh

Alvandi

Hatamian-Zarmi

et al. 2022

Biomass Conv. Bioref.

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Mushrooms of the genus Hericium spp. represent a series of delicious edible mushrooms with medicinal value. Here, for the first time, the species native to Iran, the mushroom Hericium coralloides , was collected in Mazandaran province, identified, and registered with the NCBI under accession number MW136052. The production of exopolysaccharides (EPS) in submerged culture was optimized using the response surface method. Among the physicochemical and culture medium conditions tested, rotation speed and concentration of maltose and peptone of soybean significantly affected the production of EPS. The proposed model predicts maximum EPS production (0.13 g/L) at 50 g/L maltose, 3 g/L soy peptone, and 1 g/L yeast extract, pH = 6.5, 200 rpm, inoculum at 5% v/v, and 22 °C. The molecular weight of the EPS chains was 413 and 1578 Da. EPS has antioxidant action (EC50 = 6.59 mg/mL) and cytotoxic activity against cancer cells. The viability of AGS and MKN-45 cancer cell lines declined to 20 and 30% after 48 h of the EPS treatment. H. coralloides EPS could be considered a natural dietary anti-cancer supplement. Further studies are necessary to understand the mechanism of the H. coralloides EPS activity on the cell cycle of cancer cells and to prove its action in vivo. Supplementary Information The online version contains supplementary material available at 10.1007/s13399-022-03386-0.

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“…[9] Other principal constituent of certain mushrooms such as Lentinan (derived from edible shitake mushrooms) and β-glucan ( derived from the cell wall of certain fungi) have shown to exert anti tumor effect and enhance immunity by activating natural killer cells and cytokines. [10,11]…”

Section: Necessity For Chemical Modificationmentioning

confidence: 99%

Diversity of Rationally Modified Polysaccharides for Pharmaceutical Applications

et al. 2023

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The pressing need for the development of diversified and non‐toxic biomaterials in recent decades has led to the emergence of novel and valuable structural modifications in polysaccharides to broaden their spectrum of applications. Polysaccharides are macromolecules with multifaceted diverse structures and exhibit wide range of pharmacological and biological activities. Naturally occurring polysaccharides such as starch, chitosan, alginate, acetalated dextran and pectin could potentially negate major concerns associated with the selection of suitable polysaccharides without compromising their unique bioactive nature. Chemical modification of polysaccharides offers distinctive benefits such as improved biocompatibility, stability, solubility, and functionality making them more valuable for a variety of biomedical applications such as drug delivery, gene delivery, cell culture technology and tissue engineering. The present review is a compendium of relevant chemically modified polysaccharides and discusses their role in diverse fields of pharmacy and medicine.

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Mushroom-derived polysaccharides as antitumor and anticancer agent: A concise review

Cited by 27 publications

References 119 publications

Lentinula edodes, a Novel Source of Polysaccharides with Antioxidant Power

Lentinula edodes, a Novel Source of Polysaccharides with Antioxidant Power

Antioxidant activity and cytotoxicity of exopolysaccharide from mushroom Hericium coralloides in submerged fermentation

Diversity of Rationally Modified Polysaccharides for Pharmaceutical Applications

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