Mushroom intoxication, a fatal condition in Romanian children

Mărginean, Cristina Oana; Meliţ, Lorena Elena; Mărginean, Maria Oana

doi:10.1097/md.0000000000017574

Cited by 7 publications

(4 citation statements)

References 21 publications

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“…In this study, however, more than half of the patients reported GI symptoms; additionally, non-specific symptoms, such as general weakness, were prevalent, causing difficulty in the identification of cases according to the clinical symptoms. In some previous studies, diarrhea was found to cause dehydration and severe renal failure [10,29]. In this study, diarrhea was not related to admission.…”

Section: Discussionsupporting

confidence: 46%

Mushroom intoxications presented to emergency departments in South Korea: a 2011‐2019 national registry study

2023

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This study aimed to investigate the association of characteristics and clinical outcomes of patients who presented with mushroom intoxication. We conducted a retrospective study of mushroom intoxication cases using national registry data (representative of the period 01 January 2011 to 31 December 2019). Specifically, we analyzed the demographics, vital signs, mental status, intoxication related factors, and clinical presentations of the patients. The outcomes were assessed based on general ward admission, intensive care unit (ICU) admission, length of hospitalization, and mortality. The t-test or chi-square test were used to compare the emergency department (ED) discharge group and admission group. Logistic regressions were used to predict patients that were high-risk with regards to being admitted. A total of 393 patients with mushroom intoxication were presented at the ED, and the highest number of visits occurred in the month of September. Overall, 277 (70.5%) patients were discharged from the ED and 116 (29.5%) patients were admitted. Of these, 25 (6.4%) patients were admitted to the ICU, and 3 (2.6%) patients died. Patients are more likely to be admitted to the general ward or ICU when symptoms presented after 6 h: 6 to 24 h (Odds ratio (OR) 2.158; 95% Confidence interval (CI), 1.218–3.816) or >24 h (OR: 3.382; 95% CI, 1.438–8.050). Additionally, when the patients presented with diarrhea, they were more likely to be discharged with favorable outcomes with a less likelihood for admission (OR: 0.237; 95% CI, 0.093–0.523). Most cases of mushroom intoxication presented with gastrointestinal symptoms and followed a benign course. The longer time to onset of symptoms increased the likelihood of hospitalization. Clinicians should evaluate more carefully, observe, or admit those with delayed symptom onset.

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Section: Discussionsupporting

confidence: 46%

Mushroom intoxications presented to emergency departments in South Korea: a 2011‐2019 national registry study

2023

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“…In extreme cases, the sole option for survival may be a liver transplant, which is occasionally either not possible or medically problematic. Dialysis may be necessary if renal insufficiency is severe [ 5 , 14 ]. Patients with liver failure must be moved as soon as possible to a hospital that has a liver transplantation center.…”

Section: Discussionmentioning

confidence: 99%

“…The clinical picture of patients with wild mushroom intoxication depends mainly on the type of ingested mushroom, which can range from minor gastrointestinal symptoms, such as abdominal pain, nausea, vomiting, and diarrhea, to organ failure and death. Hepatotoxicity and liver failure are associated with a small group of mushrooms [ 5 ].…”

Section: Introductionmentioning

confidence: 99%

Severe Hepatotoxicity in Mushroom Poisoning by Lepiota brunneoincarnata from Complete Recovery to Liver Transplantation: A Case Series with Review on Liver Function Tests and Liver Histopathology

Anbardar,

Soleimani,

Kazemi

et al. 2024

International Journal of Hepatology

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Background. In spite of the scientific evidence supporting health advantages of mushrooms, some of them are seriously poisonous. The clinical picture of mushroom intoxication ranges from minor gastrointestinal symptoms to organ failure, such as liver failure and death. Method. We provided demographics, clinicopathological characteristics, applied treatments, and outcomes of mushroom poisoning by Lepiota species in a series of 18 cases that were referred from Kermanshah and Lorestan provinces to Abu-Ali-Sina Hospital, Shiraz, Iran. Clinical and paraclinical data were collected by taking history and reviewing of medical documents. Pathologic findings were extracted through a review of hematoxylin and eosin pathologic slides. Results. The patients were between the ages of 18 and 67 years, composed of ten females and eight males. The most frequent clinical manifestations were nausea and vomiting followed by abdominal pain. Four cases presented decreased consciousness on admission. One of them passed away. Three other cases underwent liver transplantation, two of them died after transplantation, and one fully recovered without any major issues. All instances had elevated ALT levels, which ranged from 44 to 9,140 IU/L (mean: 3259±2476), with most of them also having concurrent AST elevations (mean: 1,361±1,532). Only few patients had modest elevations in alkaline phosphatase. Total and direct bilirubin elevations up to 47.6 and 24 mg/dL, respectively, were found in most cases. Decreased total protein and albumin concentrations and increased BUN and creatinine levels were observed in some patients. In addition, some instances revealed increased LDH, increased WBC, decreased hemoglobin, and decreased platelet count. Most patients had increased prothrombin time; hematuria and positive stool occult blood were observed in few patients. Histopathologic examination of three explanted livers revealed massive necrosis with moderate to severe macrovesicular steatosis, significant ductular reaction, and parenchymal inflammation. Other patients followed a recovery process with a considerable drop in liver enzymes, especially ALT, during hospitalization utilizing conservative treatment. They had no liver problems or relevant issues after a two-year follow-up. Conclusion. In our study, highly elevated liver enzymes with a significantly high ALT/AST ratio were observed in cases of mushroom poisoning by Lepiota species, leading to fulminant liver failure and death in some cases. These laboratory findings were correlated with liver necrosis and macrovesicular steatosis in explanted livers.

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“…Of course, a special role was played by the observance of the mating matching system, specific to the studs, to avoid inbreeding. Marginean et al (2005Marginean et al ( , 2012 and Maftei et al (2012 shows that the kinship between individuals directly influences the increase of homozygosity.…”

Section: Introductionmentioning

confidence: 99%

Study Regarding the Genetic Relationship between Broodmares from the Reproductive Nucleus of a Native Horse Breed

Maftei,

Nistor,

Defta

et al. 2023

IJAR

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Background: In this study we present a part of the genetic history of a native horse breed. Genetic analyzes are the basis of the development of strategies regarding the conservation of genetic resources and implicitly of inbreeding management plan. In this study we present another essential component of the inbreeding of a population, namely the inbreeding of broodmares themselves. Method: The method that we used in this study is based on A matrix coefficients. The research was carried out during 2012-2021, at Lucina National stud farm. The material was represented by a sample of 73 broodmares from the reproductive nucleus of the breed, from 5 bloodlines, analyzed on 5 generation of ascendants. The research was performed in the profile laboratories of the Faculty of Engineering and Management in Animal Production (Animal Sciences) from Bucharest. Results: The correlation between the breeding values of the reproductive active broodmares of Huþul from the Lucina stud, Suceava County, at the time of the analysis is 0.1875±0.0015. It was found the existence some differences between the values of the kinship coefficients of the mares born in different years, but the calculated value of the Fisher test (F= 1.3667NS) shows that the observed differences have no statistical significance.

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Mushroom intoxication, a fatal condition in Romanian children

Cited by 7 publications

References 21 publications

Mushroom intoxications presented to emergency departments in South Korea: a 2011‐2019 national registry study

Mushroom intoxications presented to emergency departments in South Korea: a 2011‐2019 national registry study

Severe Hepatotoxicity in Mushroom Poisoning by Lepiota brunneoincarnata from Complete Recovery to Liver Transplantation: A Case Series with Review on Liver Function Tests and Liver Histopathology

Study Regarding the Genetic Relationship between Broodmares from the Reproductive Nucleus of a Native Horse Breed

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