Mushroom Poisoning Outbreaks — China, 2023

Li, Haijiao; ,; Zhang, Yizhe; Zhang, Hongshun; Zhou, Jing; Chen, Zuohong; Liang, Jiaqi; Yin, Yu; He, Qian; Jiang, Shaofeng; Zhang, Yutao; Yuan, Yuan; Lang, Nan; Cheng, Bowen; Zhong, Jiaju; Li, Zhongfeng; Sun, Chengye; ,

doi:10.46234/ccdcw2024.014

Cited by 6 publications

(1 citation statement)

References 7 publications

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“…However, some wild mushrooms are poisonous due to the presence of natural toxins [4]. According to The Situation of Food Poisoning Incidents Nationwide published by the China National Health Commission, more than half of all poisoning deaths are attributed to the ingestion of poisonous mushrooms or poisonous animals and plants [5][6][7][8][9]. For example, in Yunnan, a province on the southwestern border of China, where more than half of the world's edible mushroom production originates, a significant proportion of which is for domestic consumption, there are consistently several or dozens of deaths from mushroom poisoning each year [10,11].…”

Section: Introductionmentioning

confidence: 99%

Simultaneous Determination of Multi-Class Mushroom Toxins in Mushroom and Biological Liquid Samples Using LC-MS/MS

Lu,

Zhang,

et al. 2024

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A comprehensive analytical method based on liquid chromatography–tandem mass spectrometry (LC-MS/MS) was developed for the simultaneous detection of 12 mushroom toxins (ibotenic acid, muscimol, muscarine, β-amanitin, α-amanitin, desoxoviroidin, γ-amanitin, phallisacin, illudin S, phallacidin, phalloidin and illudin M) in mushrooms, serum, urine and simulated gastric fluid. The samples were extracted with water or acetonitrile solution, and the serum sample was further purified with PSA sorbent. Chromatographic separation was performed on an ACQUITY UPLC HSS T3 column with gradient elution using methanol and water containing 1 mM ammonia fluoride as a mobile phase. Mass spectrometric acquisition was performed in electrospray positive ionization mode. Good linearities (R2 > 0.994) were obtained for 12 toxins over the range of 0.05~200 µg/L. Matrix-matched calibration curves were used for quantification. The method limits of quantification were 0.01~0.2 mg/kg for mushrooms and 0.15~2.0 µg/L for three biological liquid samples. The mean recoveries of 12 target toxins (spiked at three concentration levels) ranged from 73.0% to 110.3%, with relative standard deviations not exceeding 19.4%, which meets the requirements for the determination of trace compounds in a biological matrix. This method was applied to the analysis of mushroom samples from Yunnan Province. As a result, 11 toxins, not including illudin M, were detected with a concentration range of 0.61~2143 mg/kg.

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