Music alleviates pain perception in depression mouse models by promoting the release of glutamate in the hippocampus of mice to act on GRIK5

Mao, Xiuhua; Cai, Dandan; Lou, Wei

doi:10.1080/15257770.2022.2051048

Cited by 8 publications

(7 citation statements)

References 22 publications

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“…Music exposure did not modify thermal hyperalgesia but attenuated mechanical allodynia induced by CFA injection, an effect that was exclusively observed in females. This outcome aligns with an expanding body of literature supporting the efficacy of music across diverse rodent models (Metcalf et al 2019; Mao, Cai, and Lou 2022; A. Y. Rosalie Kühlmann et al 2018).…”

Section: Discussionsupporting

confidence: 80%

“…Numerous studies have investigated into how music interventions influence behavioral responses to pain, stress, and emotional states in different animal models (A. Y. Rosalie Kühlmann et al 2018; Metcalf et al 2019; Mao, Cai, and Lou 2022). It is important to note that animals may not listen to music in the same way humans do.…”

Section: Introductionmentioning

confidence: 99%

“…The effects of music exposure in animal models, particularly in the context of pain and mood disorders, have gained significant attention. Numerous studies have investigated into how music interventions influence behavioral responses to pain, stress, and emotional states in different animal models (A. Y. Rosalie Metcalf et al 2019;Mao, Cai, and Lou 2022). It is important to note that animals may not listen to music in the same way humans do.…”

Section: Introductionmentioning

confidence: 99%

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Dopamine dynamics in chronic pain: music-induced sex-dependent behavioral effects in mice

Flores-García,

Flores de los Heros,

Aso

et al. 2024

Preprint

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Chronic pain is a debilitating disease that is usually comorbid to anxiety and depression. Current treatment approaches primarily rely on analgesics, but they often neglect emotional aspects. Non-pharmacological interventions have been incorporated into clinics to provide a more comprehensive management of chronic pain. Among these interventions, listening to music is a well-accepted and cost-effective option. However, the underlying mechanisms of music-mediated pain relief remain insufficiently understood. Here, our aim was to evaluate the effects of music exposure in an animal model of chronic pain. First, we injected mice with the inflammatory agent complete Freund adjuvant (CFA) into the hind paw and housed them for 14 days with background music during their active period (Mozart K.205, overnight), or silence. The impact of music exposure on nociception and anxiety-like and depression-like behaviors was evaluated through different paradigms, including the hot plate, Von Frey, elevated plus maze, splash, and tail suspension tests. Additionally, we investigated whether music influences dopamine dynamics in the nucleus accumbens (NAcc), a pivotal region involved in pain processing, anhedonia, and reward. Our findings indicate that music exposure prevents the decreased NAcc activity observed in CFA-injected mice, linking with a sex-dependent reduction of allodynia, anxiety- and depression-like behaviors. Thus, females were more sensitive to music exposure. Collectively, our findings provide compelling evidence for the integration of music listening as a non-pharmacological intervention in chronic pain conditions. Moreover, the observed impact on the NAcc suggests its potential as a therapeutic target for addressing chronic pain and its associated symptoms.

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Section: Discussionsupporting

confidence: 80%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Dopamine dynamics in chronic pain: music-induced sex-dependent behavioral effects in mice

Flores-García,

Flores de los Heros,

Aso

et al. 2024

Preprint

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“…Y es que el sonido en sí nos penetra y lo percibimos físicamente debido al movimiento vibracional de la materia que nos rodea y, por lo tanto, puede afectarnos biológicamente, incluyendo un nivel emocional (Raghu, 2018) wood, membranes. De hecho, se ha observado en investigación preclínica [162] animal que la música sí influye en neurotransmisores relacionados con la nocicepción como GABA (Hao et al, 2020), serotonina y norepinefrina (Mao et al, 2022). En cuanto a ello, una limitante de los estudios abordados en esta revisión es que no llevaron a cabo un análisis cualitativo o cuantitativo de los neurotransmisores de los pacientes que tomaron musicoterapia, lo cual puede explicarse con el hecho de que esto requeriría mayor colaboración por parte de un paciente que ya tiene malestar y que en muchas ocasiones ya está siendo sometido a diversos procedimientos médicos, por lo cual este paso podría incomodarlo más en lugar de brindarle el mayor alivio posible, que es lo que se busca.…”

Section: Discussionunclassified

Musicoterapia analgésica: una revisión de los estudios recientes

Heyerdahl-Viau,

López-Naranjo

2024

FER

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Analgesic music therapy promises to be a safe alternative to complement pharmacotherapy for patients with various conditions. The aim of this narrative review is to know the effectiveness of music therapy and the quality of the clinical studies that have been carried out in this regard, which is why in this review, a search and selection of recent studies on the subject published inscientific literature databases was carried out. The selected articles were described and subsequently evaluated with the Jadad score. As a result, it was observed that despite the tendency to obtain promising results with this therapy, there is still no strongevidence to recommend its use. However, it is a versatile therapeutic approach that patients like, which is why it should continue to be studied, addressing some areas for improvement.

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“…A pain experience is often linked to anxiety [ 6 ]. Experimental studies of animal models have considered music’s potential in pain reduction, though the discrete effects are undefined and have not added much evidence toward supporting the development of defined mechanism-based music interventions in human clinical settings [ 7 ].…”

Section: Assessment-integrative Mechanismsmentioning

confidence: 99%

Underlying Music Mechanisms Influencing the Neurology of Pain: An Integrative Model

Loewy

2022

Brain Sciences

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Pain is often debilitating, and is associated with many pathologies, as either a cause or consequence. Pharmacological interventions, such as opioids, to manage pain may lead to potential problems, such as addiction. When pain is controlled and managed, it can prevent negative associated outcomes affiliated with disease. Music is a low-cost option that shows promise in the management of painful circumstances. Music therapy has provided potent options for pain relief across a variety of ages and populations. As a nonpharmacological alternative or complement lacking side effects, music interventions are growing in clinical application and research protocols. This article considers the neurological implications of varying kinds of pain to provide working considerations that preempt the use of music and music-therapy applications in treating pain.

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Music alleviates pain perception in depression mouse models by promoting the release of glutamate in the hippocampus of mice to act on GRIK5

Cited by 8 publications

References 22 publications

Dopamine dynamics in chronic pain: music-induced sex-dependent behavioral effects in mice

Dopamine dynamics in chronic pain: music-induced sex-dependent behavioral effects in mice

Musicoterapia analgésica: una revisión de los estudios recientes

Underlying Music Mechanisms Influencing the Neurology of Pain: An Integrative Model

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