Music box spine keratoderma without any systemic manifestation

Saha, Atanu; Naskar, Biswanath; Singha, Joydeep; Chaterjee, Gobinda

doi:10.4103/2229-5178.137798

Cited by 7 publications

(14 citation statements)

References 6 publications

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“…The top differential diagnoses of spiny keratoderma are porokeratosis, multiple filiform verrucae, punctate palmoplantar keratosis (Buschke‐Fischer‐Brauer disease), and arsenical keratosis . Differentiation between spiny keratoderma and porokeratosis is essential because the latter is associated with squamous cell carcinoma at the site . Clinically, porokeratosis usually presents with plaques or annular lesions with a raised ridge at the periphery and histologically, besides the column of parakeratosis, there is underlying dyskeratosis and vacuolated keratinocytes in the epidermis, which are not observed in spiny keratoderma.…”

Section: Discussionmentioning

confidence: 99%

Spiny keratoderma: Report of three cases

Azevedo

Sodré

Santangelo

et al. 2019

J of Cosmetic Dermatology

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Background Spiny keratoderma shows “music box spine” keratotic papules limited to the palms and soles and these lesions do not cause any trouble besides the cosmetic impairment and the sensation of roughness of hands and soles. Aim To present cases and review the literature on spiny keratoderma. Patients/Methods, Results Three cases of spiny keratoderma are presented. The first case is a 52‐year‐old man with protein S deficiency presented with multiple spiny keratotic papules on palms and soles for more than 30 years, referring to remove them with a razor blade. The second case is an 84‐year‐old man who was hospitalized due to a rectal adenocarcinoma diagnosed 2 months before and presented multiples papules on palms and soles that were present for more than 50 years, with worsening after being bedridden. The third case is a 59‐year‐old woman who had since birth together with relatives the same type of spiny keratotic papules on palms and soles. Conclusion The authors discuss the epidemiologic data and differential diagnosis of spiny keratoderma, as well as the related literature. Associations with systemic disease or malignancy occur in some acquired cases. It is important to distinguish from other palmoplantar keratodermas as some of that can be linked to cutaneous and internal malignancies. To date, no cases of spiny keratoderma in patients with protein S deficiency and only one case of association with rectal carcinoma have been reported.

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Section: Discussionmentioning

confidence: 99%

Spiny keratoderma: Report of three cases

Azevedo

Sodré

Santangelo

et al. 2019

J of Cosmetic Dermatology

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“…Arsenical keratoses result from chronic arsenic exposure and can potentially progress to invasive squamous cell carcinoma. 2 Gray-to-yellow hyperkeratotic papules are most commonly located on the palms and soles. 1 Histopathologically, keratinocytes demonstrate cellular atypia and marked vacuolization.…”

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confidence: 99%

“…4 FAH – Incorrect. FAH is often considered a variant of acrokeratoelastoidosis 2 and typically manifests in childhood or adolescence. 1 Asymptomatic, round-to-oval, yellow or translucent papules occur on the palms and soles.…”

mentioning

confidence: 99%

“… 1 Histopathology shows hyperkeratosis, hypergranulosis, and mild acanthosis 1 ; elastorrhexis is present in acrokeratoelastoidosis but not FAH. 1 , 2 …”

mentioning

confidence: 99%

“…A history of environmental or occupational chemical exposure would be more likely in the case of arsenic keratoses. 1 , 2 Immunosuppression – Incorrect. The prevalence of porokeratosis is found to be higher in immunosuppressed individuals, suggesting that immunosuppression or immunodeficiency may increase the risk of porokeratosis in those who are genetically predisposed.…”

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confidence: 99%

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Palmoplantar hyperkeratotic projections

2020

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An 81-year-old woman reported a 1-year history of intermittently pruritic rough bumps on her palms and soles that had steadily increased in number. She denied associated hyperhidrosis and denied a personal or family history of skin disease. She had a history of breast cancer in remission, hypertension, diabetes mellitus, hypothyroidism, and hyperlipidemia with elevated low-density lipoprotein cholesterol and normal triglycerides for which she took a statin. On examination, scattered discrete hyperkeratotic projections were noted on her bilateral palms and soles (Fig 1). Histopathology found columns of compact hyperkeratosis and parakeratosis with underlying hypogranulosis and without underlying dyskeratosis in the spinous layer (Fig 2). Question 1: What is the most likely diagnosis?A. Buschke-Fisher-Brauer disease (punctate palmoplantar keratoderma type I)

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“Gloves cling to my hands”

Jorge

2018

The Nurse Practitioner

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Music box spine keratoderma without any systemic manifestation

Cited by 7 publications

References 6 publications

Spiny keratoderma: Report of three cases

Spiny keratoderma: Report of three cases

Palmoplantar hyperkeratotic projections

“Gloves cling to my hands”

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