Music, immunity and cancer

Núñez, M. R.; Mañá, Paula; Liñares, David; Riveiro, María P.; Balboa, José; Suárez‐Quintanilla, Juan; Maracchi, Mónica; Rey-Méndez, Manuel; López, José Manuel García; Freire‐Garabal, Manuel

doi:10.1016/s0024-3205(02)01796-4

Cited by 65 publications

(34 citation statements)

References 24 publications

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“…Our study also has implications for other chronic medical conditions including cancer. Music and EE-based interventions may serve as preclinical surrogate for developing adjunct digital therapeutics for cancer patients (43,58,127), since music can lower cancer-treatment biomarker IL-6 (94,112,145) while EE and physical exercise can reduce tumor size and increase lifespan in cancer animal models (127,128,146). Other clinical opportunities to combine non-pharmacological modalities with pharmaceutical drugs and biologics include Parkinson's and Alzheimer's diseases (21), asthma (147), arthritis (148) and affective disorders (143,149).…”

Section: Translational Implications Of Studying Enriched Environmentmentioning

confidence: 99%

Music-Enhanced Analgesia and Antiseizure Activities in Animal Models of Pain and Epilepsy: Toward Preclinical Studies Supporting Development of Digital Therapeutics and Their Combinations With Pharmaceutical Drugs

Metcalf

Huntsman

Garcia³

et al. 2019

Front. Neurol.

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Digital therapeutics (software as a medical device) and mobile health (mHealth) technologies offer a means to deliver behavioral, psychosocial, disease self-management and music-based interventions to improve therapy outcomes for chronic diseases, including pain and epilepsy. To explore new translational opportunities in developing digital therapeutics for neurological disorders, and their integration with pharmacotherapies, we examined analgesic and antiseizure effects of specific musical compositions in mouse models of pain and epilepsy. The music playlist was created based on the modular progression of Mozart compositions for which reduction of seizures and epileptiform discharges were previously reported in people with epilepsy. Our results indicated that music-treated mice exhibited significant analgesia and reduction of paw edema in the carrageenan model of inflammatory pain. Among analgesic drugs tested (ibuprofen, cannabidiol (CBD), levetiracetam, and the galanin analog NAX 5055), music intervention significantly decreased paw withdrawal latency difference in ibuprofen-treated mice and reduced paw edema in combination with CBD or NAX 5055. To the best of our knowledge, this is the first animal study on music-enhanced antinociceptive activity of analgesic drugs. In the plantar incision model of surgical pain, music-pretreated mice had significant reduction of mechanical allodynia. In the corneal kindling model of epilepsy, the cumulative seizure burden following kindling acquisition was lower in animals exposed to music. The music-treated group also exhibited significantly improved survival, warranting further research on music interventions for preventing Sudden Unexpected Death in Epilepsy (SUDEP). We propose a working Metcalf et al. Music-Enhanced Analgesic and Antiseizure Activities model of how musical elements such as rhythm, sequences, phrases and punctuation found in K.448 and K.545 may exert responses via parasympathetic nervous system and the hypothalamic-pituitary-adrenal (HPA) axis. Based on our findings, we discuss: (1) how enriched environment (EE) can serve as a preclinical surrogate for testing combinations of non-pharmacological modalities and drugs for the treatment of pain and other chronic diseases, and (2) a new paradigm for preclinical and clinical development of therapies leading to drug-device combination products for neurological disorders, depression and cancer. In summary, our present results encourage translational research on integrating non-pharmacological and pharmacological interventions for pain and epilepsy using digital therapeutics.

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Section: Translational Implications Of Studying Enriched Environmentmentioning

confidence: 99%

Music-Enhanced Analgesia and Antiseizure Activities in Animal Models of Pain and Epilepsy: Toward Preclinical Studies Supporting Development of Digital Therapeutics and Their Combinations With Pharmaceutical Drugs

Metcalf

Huntsman

Garcia³

et al. 2019

Front. Neurol.

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“…Music exposure has been shown to enhance lymphocyte function in the brain, thereby reversing stress induced immunosuppression of rats during a controlled trial with two treatments, music and auditory stress (Núñez et al, 2002). Like music, group drumming therapy in age- and sex-matched human volunteers has been shown to enhance cellular immunity by increasing lymphocyte activated NK cell activity during a single trial experimental intervention with control groups (Bittman et al, 2001).…”

Section: Environmental Enrichmentmentioning

confidence: 99%

Cellular and molecular mechanisms of immunomodulation in the brain through environmental enrichment

Singhal

Jaehne

Corrigan

et al. 2014

Front. Cell. Neurosci.

165

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Recent studies on environmental enrichment (EE) have shown cytokines, cellular immune components [e.g., T lymphocytes, natural killer (NK) cells], and glial cells in causal relationship to EE in bringing out changes to neurobiology and behavior. The purpose of this review is to evaluate these neuroimmune mechanisms associated with neurobiological and behavioral changes in response to different EE methods. We systematically reviewed common research databases. After applying all inclusion and exclusion criteria, 328 articles remained for this review. Physical exercise (PE), a form of EE, elicits anti-inflammatory and neuromodulatory effects through interaction with several immune pathways including interleukin (IL)-6 secretion from muscle fibers, reduced expression of Toll-like receptors on monocytes and macrophages, reduced secretion of adipokines, modulation of hippocampal T cells, priming of microglia, and upregulation of mitogen-activated protein kinase phosphatase-1 in central nervous system. In contrast, immunomodulatory roles of other enrichment methods are not studied extensively. Nonetheless, studies showing reduction in the expression of IL-1β and tumor necrosis factor-α in response to enrichment with novel objects and accessories suggest anti-inflammatory effects of novel environment. Likewise, social enrichment, though considered a necessity for healthy behavior, results in immunosuppression in socially defeated animals. This has been attributed to reduction in T lymphocytes, NK cells and IL-10 in subordinate animals. EE through sensory stimuli has been investigated to a lesser extent and the effect on immune factors has not been evaluated yet. Discovery of this multidimensional relationship between immune system, brain functioning, and EE has paved a way toward formulating environ-immuno therapies for treating psychiatric illnesses with minimal use of pharmacotherapy. While the immunomodulatory role of PE has been evaluated extensively, more research is required to investigate neuroimmune changes associated with other enrichment methods.

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“…There is also evidence that music may lead to production of hormones and neurotransmitters that participate in T cell proliferation and antitumor signaling. 31,32 Explanations for certain phenomena, such as learning, have become possible with knowledge of the effect of music on the production of messengers. For example, music influences production of steroids including cortisol, testosterone, and estrogen as well as their receptor proteins, leading to neurogenesis and improvements in learning in the brain.…”

mentioning

confidence: 99%

The Effect of Music on the Production of Neurotransmitters, Hormones, Cytokines, and Peptides: A Review

Gangrade¹

2011

Music and Medicine

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Research on the effects of music exposure on the release of biochemical messengers is an expanding field. The importance of understanding the influence of music on messenger production is a means of explaining behavioral reactions through physiological mechanisms. Signaling molecules that prove integral for important regulatory functions include neurotransmitters, hormones, cytokines, and peptides. Thus music elicits responses promoting positive emotions, alleviation of stress, and immune function. Study of the production of the messengers reveals the connection between the mind and the body. The purpose of the review is to provide a closer look into the effectual relationship between music and production of these messengers by providing literature and analysis.

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Music, immunity and cancer

Cited by 65 publications

References 24 publications

Music-Enhanced Analgesia and Antiseizure Activities in Animal Models of Pain and Epilepsy: Toward Preclinical Studies Supporting Development of Digital Therapeutics and Their Combinations With Pharmaceutical Drugs

Music-Enhanced Analgesia and Antiseizure Activities in Animal Models of Pain and Epilepsy: Toward Preclinical Studies Supporting Development of Digital Therapeutics and Their Combinations With Pharmaceutical Drugs

Cellular and molecular mechanisms of immunomodulation in the brain through environmental enrichment

The Effect of Music on the Production of Neurotransmitters, Hormones, Cytokines, and Peptides: A Review

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