Music therapy inhibits morphine-seeking behavior via GABA receptor and attenuates anxiety-like behavior induced by extinction from chronic morphine use

Kim, Ki Jin; Lee, Sang-Nam; Lee, Bong Hyo

doi:10.1016/j.neulet.2018.03.035

Cited by 11 publications

(8 citation statements)

References 27 publications

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“…Children given music therapy experienced a calming and relaxed state (Nilsson et al, 2009). An interesting study showed that Korean traditional music reduces stress and anxiety in rats (Kim et al, 2018). Our results revealed that exposure to classical music versus hard rock music during prenatal period plus 60 days postpartum reduced anxiety-like behavior as assessed by an EPM task.…”

Section: Discussionmentioning

confidence: 99%

“…This model is based on an aversion to open spaces, which is denoted by the animal spending more time in the enclosed arms of the maze. Therefore, the more time spent in the closed arms and the more number of entries into closed arms by the animals indicate anxiety behavior (Habibitabar et al, 2020; Kim et al, 2018). The schematic representation of the EPM apparatus is indicated in Figure 1A…”

Section: Methodsmentioning

confidence: 99%

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Retracted: Prenatal Exposure to Classical Music Improves Learning and Memory in Adult Rats

Zhang¹,

Vatanpour

et al. 2022

European Journal of Psychology Open

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Abstract. Background: Exposure to music during pregnancy enhances brain development and improves learning in neonatal rats. Methods: In these experiments, we examined the effects of exposure to silence, hard rock, classical, and rap music in utero plus 60 days postpartum on learning and memory in adult Wistar rats. Passive avoidance learning (PAL) was assessed at age 60 days, and a retention test was done 24 hours after training. Elevated plus maze (EPM) was also used as a standard behavioral task for assessing the effects of music therapy on anxiety. Furthermore, we measured serum corticosterone levels and adrenal weight at the end of experiments to show the possible effect of stress on the rats’ behavior. Results: Hard rock music impaired acquisition, increasing the number of trials to acquisition in PAL task. Hard rock music also impaired the retrieval process by decreasing step-through latency and increasing time spent in the dark compartment during the retention trial. Further, in the hard rock group, there were increases in serum corticosterone and adrenal weight of rats. Classical music, in turn, improved acquisition learning and retention memory and decreased serum corticosterone levels compared to the silence group. Rats’ exposure to rap music did not show any significant change in acquisition and retrieval processes compared to the silence group. In the EPM task, classical music exposure had anxiolytic-like effects revealed in an increase in the number of entries into open arms and time spent in the open arms. However, in this task, hard rock music induced an anxiogenic effect. Conclusions: Prenatal and postnatal exposure to music improves PAL and memory in adult rats. The effects of music therapy with classical music might be related to stress reduction by lowering corticosterone as a stress biomarker or anxiolytic effects; this deserves further examination.

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Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Retracted: Prenatal Exposure to Classical Music Improves Learning and Memory in Adult Rats

Zhang¹,

Vatanpour

et al. 2022

European Journal of Psychology Open

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“…Music stimulation might suppress agitated behavior by influencing the gamma aminobutyric acid (GABA) receptor pathway. GABA is one of the major inhibitory neurotransmitter receptors in the brain [28], and GABA can become synchronized to music stimuli, resulting in a calming effect [29]. Overall, our results could be used as a foundation for future research on the effect of music interventions on agitation.…”

Section: Discussionmentioning

confidence: 88%

Effects of Two Music Therapy Methods on Agitation and Anxiety among Patients Weaning off Mechanical Ventilation: A Pilot Study

Park

2019

J Korean Acad Fundam Nurs

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Purpose: The feasibility and differential effects of two music therapy methods (interventions with preferred music vs. classical relaxation music) were done to examine the effects on agitation and anxiety in patients weaning off mechanical ventilation. Methods: This pilot study was conducted using a crossover design. Six patients listened to preferred music choices and classical relaxation music. Anxiety scores were measured using the Richmond Agitation Sedation Scale (RASS), State-Trait Anxiety Inventory (STAI), and visual analog scale (VAS). Results: Patients showed a significant decrease in agitation and anxiety after both the preferred and classical relaxation music interventions. The difference in the effects of preferred music and that of classical relaxation music was not significant. As for feasibility, patients exhibited a change in agitated behaviors after the music interventions by not trying to take off medical devices and quietly listening to the music, and by smiling and moving lips along with the lyrics while listening. Conclusion: Music interventions which centered on either patients' preferences or classical relaxation music to enhance relaxation, helped reduce agitation and anxiety during the mechanical ventilation weaning process.

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“…Yoga breathing has been shown to significantly increase GABA levels [ 150 ]. At least one study has also shown that certain relaxing music therapy acts via the GABA receptor and that this effect was blocked by the GABA receptor antagonists [ 151 ].…”

Section: Discussionmentioning

confidence: 99%

The Aging GABAergic System and Its Nutritional Support

Mills¹

2021

Journal of Nutrition and Metabolism

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Aging is associated with a decline in hormones and an associated decline in GABAergic function and calcium and ion current dysregulation. Neurosteroid hormones act as direct calcium channel blockers, or they can act indirectly on calcium channels through their interaction with GABA receptors. The calcium channel dysfunction associated with hormone loss further leads to an excitatory cell state, which can ultimately lead to cell death. The calcium theory of aging posits that cellular mechanisms, which maintain the homeostasis of cytosol Ca2+ concentration, play a key role in brain aging and that sustained changes in Ca2+ homeostasis provide the final common pathway for age-associated brain changes. There is a link between hormone loss and calcium dysregulation. Loss of calcium regulation associated with aging can lead to an excitatory cell state, primarily in the mitochondria and nerve cells, which can ultimately lead to cell death if not kept in check. A decline in GABAergic function can also be specifically tied to declines in progesterone, allopregnanolone, and DHEA levels associated with aging. This decline in GABAergic function associated with hormone loss ultimately affects GABAergic inhibition or excitement and calcium regulation throughout the body. In addition, declines in GABAergic function can also be tied to vitamin status and to toxic chemicals in the food supply. The decline in GABAergic function associated with aging has an effect on just about every body organ system. Nutritional support of the GABAergic system with supportive foods, vitamins, and GABA or similar GABA receptor ligands may address some of the GABAergic dysfunction associated with aging.

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Music therapy inhibits morphine-seeking behavior via GABA receptor and attenuates anxiety-like behavior induced by extinction from chronic morphine use

Cited by 11 publications

References 27 publications

Retracted: Prenatal Exposure to Classical Music Improves Learning and Memory in Adult Rats

Retracted: Prenatal Exposure to Classical Music Improves Learning and Memory in Adult Rats

Effects of Two Music Therapy Methods on Agitation and Anxiety among Patients Weaning off Mechanical Ventilation: A Pilot Study

The Aging GABAergic System and Its Nutritional Support

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