This research aims to study the psychophysiological effects of music on humans. This is qual-itative research of an exploratory nature. Initially, a Literature Review on the subject was im-plemented to support the analysis of two videos - that of an elderly woman with dementia and that of a six-month-old baby, both exposed to a musical experience. Three evaluators were invited to participate in the research: two music professionals – a Music Therapist and a Music Educator, and a Professional from another area. Through the technique of Content Analysis, the speeches of the three evaluators on the two videos outlined four categories of psychophysiological effects of music. They were: (1) music, emotion, and expression; (2) mu-sic and cognition; (3) music, rhythm, and movement; (4) music and physiology. These cate-gories were confirmed by the theoretical references studied. It is concluded that the psy-chophysiological effects of music on human beings are powerful and profound, even at the extremes of life. Music can be a stimulating and modifying agent of emotions, memories, movements, and subjective meanings that it provides to each individual. It sensitizes and produces narratives that fit into the time of the one who experiences it.