Mussel-Derived, Cancer-Targeting Peptide as pH-Sensitive Prodrug Nanocarrier

Ma, Yue; He, Peiyan; Tian, Xiaohua; Liu, Guanglei; Zeng, Xiaowei; Pan, Guoqing

doi:10.1021/acsami.9b09031

Cited by 53 publications

(45 citation statements)

References 55 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Molecular Synthesis and Surface Functionalization. The clickable mussel-inspired peptide was prepared by solid-phase peptide synthesis according to our previously reported method (38)(39)(40). Briefly, DOPA, a catecholic amino acid abundant in Mfps (30,41), was introduced into the peptide sequence using acetonideprotected Fluorenylmethyloxycarbonyl-DOPA(acetone)-OH.…”

Section: Resultsmentioning

confidence: 99%

Bioclickable and mussel adhesive peptide mimics for engineering vascular stent surfaces

Yang

Zhao

Hao

et al. 2020

Proc. Natl. Acad. Sci. U.S.A.

Self Cite

117

View full text Add to dashboard Cite

Thrombogenic reaction, aggressive smooth muscle cell (SMC) proliferation, and sluggish endothelial cell (EC) migration onto bioinert metal vascular stents make poststenting reendothelialization a dilemma. Here, we report an easy to perform, biomimetic surface engineering strategy for multiple functionalization of metal vascular stents. We first design and graft a clickable mussel-inspired peptide onto the stent surface via mussel-inspired adhesion. Then, two vasoactive moieties [i.e., the nitric-oxide (NO)-generating organoselenium (SeCA) and the endothelial progenitor cell (EPC)-targeting peptide (TPS)] are clicked onto the grafted surfaces via bioorthogonal conjugation. We optimize the blood and vascular cell compatibilities of the grafted surfaces through changing the SeCA/TPS feeding ratios. At the optimal ratio of 2:2, the surface-engineered stents demonstrate superior inhibition of thrombosis and SMC migration and proliferation, promotion of EPC recruitment, adhesion, and proliferation, as well as prevention of in-stent restenosis (ISR). Overall, our biomimetic surface engineering strategy represents a promising solution to address clinical complications of cardiovascular stents and other blood-contacting metal materials.

show abstract

Section: Resultsmentioning

confidence: 99%

Bioclickable and mussel adhesive peptide mimics for engineering vascular stent surfaces

Yang

Zhao

Hao

et al. 2020

Proc. Natl. Acad. Sci. U.S.A.

Self Cite

117

View full text Add to dashboard Cite

show abstract

“…Nevertheless, the opposite is true at a basic pH as catechol–boronate complexes can be formed instead. Additionally, this chemistry has been widely exploited to prepare pH‐responsive capsules, [ 150 ] assemblies, [ 151 ] and coatings, [ 152 ] which have utilities in bioimaging, cancer cell targeting, and drug delivery (Figure 6A, b,c). It has also ignited great interest in the development of self‐healing materials that work under ambient humidity conditions.…”

Section: Control Of Phenolic Chemistrymentioning

confidence: 99%

“…Reproduced with permission. [ 151 ] Copyright 2019, American Chemical Society. d) Formation of catechol–boronate inspired dynamic biointerface and its sugar‐responsiveness for applications in e) modulation of cell adhesion and f) cancer‐cell isolation.…”

Section: Control Of Phenolic Chemistrymentioning

confidence: 99%

Strategic Advances in Spatiotemporal Control of Bioinspired Phenolic Chemistries in Materials Science

Jia

Wen

Cheng

et al. 2021

Adv Funct Materials

View full text Add to dashboard Cite

Nature-inspired phenolic chemistries have substantially nourished the engineering of advanced materials for widespread applications in energy, catalysis, and biomedicine, among others. To achieve predictable yet adaptable material structures and properties, the spatial and/or temporal control over the phenolic chemistries per se is increasingly demanded. In this review, a systematic overview of recent strategical advances in the spatiotemporal control of phenolic chemistries in materials science is given. The chemical diversity and reactivity of catechols and polyphenols are first introduced as phenolic building blocks. With a main focus on catechols (especially dopamine), renewed insights into their mechanisms of polymerization/assembly, adhesion, and cohesion are provided. The conditions for tuning phenolic polymerization/assembly are also outlined. This paper focuses on the latest strategies for imparting controlled manipulation of phenolic chemistries in terms of many aspects: growth kinetics, chemical compositions and structures, dimensions and architectures, spatial patterns, and surface functionality. Finally, critical issues facing this field with perspectives delivered on future research are discussed. As envisaged, this review will provide helpful guidance to orchestrate state-of-the-art phenolic chemistries and materials science for producing materials with intended, application-oriented properties and functions.

show abstract

“…The in vivo experimental results showed that this system could effectively deliver drug to tumor cells and suppresstumor growth. 43 Recently, several limitations of single drug cancer chemotherapy have been reported such as poor bioavailability, low therapeutic efficacy, and multidrug resistance. 44 Therefore, combination chemotherapy of two or more anticancer drugs has been thoroughly investigated and extensively developed in the past few years.…”

Section: Introductionmentioning

confidence: 99%

<p>Co-Delivery of Paclitaxel and Doxorubicin by pH-Responsive Prodrug Micelles for Cancer Therapy</p>

Jiang¹,

Zhou²,

Zhang³

et al. 2020

IJN

View full text Add to dashboard Cite

Background: It is of great significance to develop intelligent co-delivery systems for cancer chemotherapy with improved therapeutic efficacy and few side-effects. Materials and Methods: Here, we reported a co-delivery system based on pH-sensitive polyprodrug micelles for simultaneous delivery of doxorubicin (DOX) and paclitaxel (PTX) as a combination chemotherapy with pH-triggered drug release profiles. The physicochemical properties, drug release profiles and mechanism, and cytotoxicity of PTX/DOX-PMs have been thoroughly investigated. Results and Discussion: The pH-sensitive polyprodrug was used as nanocarrier, and PTX was encapsulated into the micelles with high drug-loading content (25.6%). The critical micelle concentration (CMC) was about 3.16 mg/L, indicating the system could form the micelles at low concentration. The particle size of PTX/DOX-PMs was 110.5 nm, and increased to approximately 140 nm after incubation for 5 days which showed that the PTX/DOX-PMs had high serum stability. With decrease in pH value, the particle size first increased, and thenwas no longer detectable. Similar change trend was observed for CMC values. The zetapotential increased sharply with decrease in pH. These results demonstrated the pHsensitivity of PTX/DOX-PMs. In vitro drug release experiments and study on release mechanism showed that the drug release rate and accumulative release for PTX and DOX were dependent on the pH, showing the pH-triggered drug release profiles. Cytotoxicity assay displayed that the block copolymer showed negligible cytotoxicity, while the PTX/ DOX-PMs possessed high cytotoxic effect against several tumor cell lines compared with free drugs and control. Conclusion: All the results demonstrated that the co-delivery system based on pH-sensitive polyprodrug could be a potent nanomedicine for combination cancer chemotherapy. In addition, construction based on polyprodrug and chemical drug could be a useful method to prepare multifunctional nanomedicine.

show abstract

Mussel-Derived, Cancer-Targeting Peptide as pH-Sensitive Prodrug Nanocarrier

Cited by 53 publications

References 55 publications

Bioclickable and mussel adhesive peptide mimics for engineering vascular stent surfaces

Bioclickable and mussel adhesive peptide mimics for engineering vascular stent surfaces

Strategic Advances in Spatiotemporal Control of Bioinspired Phenolic Chemistries in Materials Science

<p>Co-Delivery of Paclitaxel and Doxorubicin by pH-Responsive Prodrug Micelles for Cancer Therapy</p>

Contact Info

Product

Resources

About