Mussel Foot Protein Inspired Tape‐Type Adhesive with Water‐Responsive, High Conformal, Tough, and On‐Demand Detachable Adhesion to Wet Tissue

Ni, Peng; Huang, Hongjian; Zhang, Lidan; Chen, Yiming; Liang, Ziyi; Weng, Yunxiang; Fang, Yan; Liu, Haiqing

doi:10.1002/adhm.202203342

Cited by 9 publications

(3 citation statements)

References 41 publications

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“…However, the interfacial adhesion is relatively weak to low surface energy adherends such as PE, PC, and PMMA because van der Waals and hydrophobic associations prevail at the interfaces. The interfacial toughness of mTA 5 -PAA/PEI 3 exceeds that of many reported wTA PEC hydrogel materials, such as polyTA–PETEA–PEGDA–agar and PAGU hydrogels with wet interfacial toughness values of 858 and 818 J/m 2 , respectively, and the interface toughness of our work is approximately 1.8 times that of both (Figure I and Table S3) ,,– and higher than that of common commercial TAs, such as commercially available cyanoacrylate (Histoyl) and fibrin sealant (Tisseel), both of which have interfacial toughness less than 20 J/m 2 …”

Section: Resultsmentioning

confidence: 45%

Robust but On-Demand Detachable Wet Tissue Adhesive Hydrogel Enhanced with Modified Tannic Acid

Wang,

Huang,

et al. 2023

ACS Appl. Mater. Interfaces

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Adhesives with robust but readily detachable wet tissue adhesion are of great significance for wound closure. Polyelectrolyte complex adhesive (PECA) is an important wet tissue adhesive. However, its relatively weak cohesive and adhesive strength cannot satisfy clinical applications. Herein, modified tannic acid (mTA) with a catechol group, a long alkyl hydrophobic chain, and a phenyl group was prepared first, and then, it was mixed with acrylic acid (AA) and polyethylenimine (PEI), followed by UV photopolymerization to make a wet tissue adhesive hydrogel with tough cohesion and adhesion strength. The hydrogel has a strong wet tissue interfacial toughness of ∼1552 J/m2, good mechanical properties (∼7220 kPa cohesive strength, ∼873% strain, and ∼33,370 kJ/m3 toughness), and a bursting pressure of ∼1575 mmHg on wet porcine skin. The hydrogel can realize quick and effective adhesion to various wet biological tissues including porcine skin, liver, kidney, and heart and can be changed easily with triggering urea solution to avoid tissue damage or uncomfortable pain to the patient. This biosafe adhesive hydrogel is very promising for wound closure and may provide new ideas for the design of robust wet tissue adhesives.

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Section: Resultsmentioning

confidence: 45%

Robust but On-Demand Detachable Wet Tissue Adhesive Hydrogel Enhanced with Modified Tannic Acid

Wang,

Huang,

et al. 2023

ACS Appl. Mater. Interfaces

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“…However, the interaction between the hydrogel and wood interface is more mechanically interlocking than that between hydrogel and PET. [43]…”

Section: Wet Adhesive Mechanism and Debondingmentioning

confidence: 99%

Tough and On‐Demand Detachable Wet Tissue Adhesive Hydrogel Made from Catechol Derivatives with a Long Aliphatic Side Chain

Chen

et al. 2023

Adv Healthcare Materials

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Wet adhesion is critical in cases of wound closure, but it is usually deterred by the hydration layer on tissues. Inspired by dopamine‐mediated underwater adhesion in mussel foot proteins, wet tissue adhesives containing catechol with 2–3 carbons side chains are reported mostly. To make wet adhesion of this type of adhesives much tougher, catechol derivatives with a long aliphatic side chain (≈10 atoms length) are synthesized. Then, a series of strong wet tissue adhesive hydrogels are prepared through photoinduced copolymerization of acrylic acid with synthetic monomers. The adhesive hydrogel has a high cohesion strength, that is, tensile strength and strain, and toughness of ≈1800 kPa, ≈540%, and ≈4100 kJ m−3, respectively. Its interfacial toughness on wet and underwater porcine skin is respectively ≈1300 and ≈1100 J m−2, and its adhesion strength to wet porcine skin is ≈153 kPa. These values are much higher than those of dopamine‐based adhesives in the same conditions, demonstrating that the long aliphatic side chain on catechol can greatly improve the wet tissue‐adhesion. Additionally, the tough interfacial adhesion can be broken on demand with 5 wt.% aqueous urea solution. This adhesive hydrogel is highly promising in safe wound closure.

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“…[39] Recently, on-demand detachable adhesive tape was developed for wet tissue adhesion by Peng et al but it needs UV-radiation for curing the adhesive and the resulted adhesive tape has inferior optical transparency as compared to our PECs adhesive, which discussed in next section. [41]…”

Section: Adhesive Strength Testing On Mammalian Bonesmentioning

confidence: 99%

Underwater Adhesives from Redox‐Responsive Polyplexes of Thiolated Polyamide Polyelectrolytes

Sharma,

Dutta,

Srivastava

2023

Chemistry A European J

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We report the fabrication of optically clear underwater adhesives using polyplexes of oppositely charged partially‐thiolated polyamide polyelectrolytes (TPEs). The thiol content of the constituent PEs was varied to assess its influence on the adhesive properties of the resulting glues. These catechol‐free, redox‐responsive TPE‐adhesives were formulated in aquo and exhibited high optical transparency and strong adhesion even on submerged or moist surfaces of diverse polar substrates such as glass, aluminium, wood, and bone pieces. The adhesives could be cured under water through oxidative disulphide crosslinking of the constituent TPEs. The polyamide backbone provided multi‐site H‐bonding interactions with the substrates while the disulphide crosslinking provided the cohesive strength to the glue. Strong adhesion of mammalian bones (load bearing capacity upto 7 kg/cm2) was achieved using the adhesive containing 30 mol% thiol residues. Higher pH and use of oxidants such as povidone‐iodine solution enhanced the curing rate of the adhesives, and so did the use of Tris buffer instead of Phosphate buffer. The porous architecture of the adhesive and its progressive degradation in aqueous medium over the course of three weeks bode well for diverse biomedical applications where temporary adhesion of tissues is required.

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Mussel Foot Protein Inspired Tape‐Type Adhesive with Water‐Responsive, High Conformal, Tough, and On‐Demand Detachable Adhesion to Wet Tissue

Cited by 9 publications

References 41 publications

Robust but On-Demand Detachable Wet Tissue Adhesive Hydrogel Enhanced with Modified Tannic Acid

Robust but On-Demand Detachable Wet Tissue Adhesive Hydrogel Enhanced with Modified Tannic Acid

Tough and On‐Demand Detachable Wet Tissue Adhesive Hydrogel Made from Catechol Derivatives with a Long Aliphatic Side Chain

Underwater Adhesives from Redox‐Responsive Polyplexes of Thiolated Polyamide Polyelectrolytes

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