Mussel foot protein inspired tough tissue-selective underwater adhesive hydrogel

Cotton gauze is a widely used topical hemostatic material for bleeding control, but its high blood absorption capacity tends to cause extra blood loss. Therefore, development of rapid hemostatic cotton gauze with less blood loss is of great significance. Here, we develop an efficient hemostatic cotton gauze whose surface is slightly modified with a catechol compound which features a flexible long hydrophobic alkyl chain terminated with a catechol group. Its hemostatic performance in animal injuries is superior to standard cotton gauze and Combat GauzeTM. Its biosafety is similar to cotton gauze and rebleeding hardly occurs when the gauze is removed. Here, we show its hemostatic capability is attributable to the rapid formation of big and thick primary erythrocyte clots, due to its effective controlling of blood movement through blocking effect from tissue adhesion by catechol, blood wicking in cotton, and the hydrophobic effect from long alkyl chains.

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“…13 ). This further confirms that catechol group plays an essential role in the wet tissue adhesion 26 – 28 .…”

Section: Resultssupporting

confidence: 76%

Efficient, biosafe and tissue adhesive hemostatic cotton gauze with controlled balance of hydrophilicity and hydrophobicity

Zhou

Gao

et al. 2022

Nat Commun

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“…e) Strong adhesion (>5 kg) demonstration between PAA–Fe–Li and PVA, where the adhesion interface diameter was 6 mm. The PAA–Fe–Li and PVA hydrogels had been adhered for 24 h. f) Adhesive strength of PAA–Fe–Li hydrogels compared to other soft material adhesives, whose adhered substrates were biological tissues (orange), [ 7,15,37,40–43 ] hydrogels (purple), [ 10,20,44,45 ] and elastomers (blue). [ 19 ] g) Comparison of adhesion performance between the proposed electroadhesion strategy and existing hydrogel–hydrogel adhesion strategies reported in the literature.…”

Section: Resultsmentioning

confidence: 99%

“…[ 49,50 ] This was advantageous for PAA–Fe–Li to effectively facilitate hydrogel adhesion while preventing unintended adhesion. [ 40,41,48 ] In terms of PVA, the peak adhesive strength and adhesive energy could reach 1.2 MPa and 3750 J m −2 , respectively (Figures S13 and S14, Supporting Information). The adhered PAA–Fe–Li and PVA samples with a cross‐sectional diameter of 6 mm could bear a weight of at least 5 kg, as confirmed in Figure 4e and Movie S2 (Supporting Information).…”

Section: Resultsmentioning

confidence: 99%

Electrically Programmable Interfacial Adhesion for Ultrastrong Hydrogel Bonding

Liu

Wang

et al. 2022

Advanced Materials

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Adjustable interfacial adhesion is of great significance in smart‐hydrogel‐related engineering fields. This study presents an electroadhesion strategy for universal and ultrastrong hydrogel bonding with electrically programmable strength. An ionic hydrogel containing lithium ions is designed to achieve hydrated‐ion‐diffusion‐mediated interfacial adhesion, where external electric fields are employed to precisely control spatiotemporal dynamics of the ion diffusion across ionic adhesion region (IAR). The hydrogel can realize a universal, ultrastrong, efficient, tough, reversible, and environmentally tolerant electroadhesion to diverse hydrogels, whose peak adhesion strength and interfacial adhesion toughness are as high as 1.2 MPa and 3750 J m−2, respectively. With a mechanoelectric coupling model, the dominant role of the hydrated ions in IAR played in the interfacial electroadhesion is further quantitatively revealed. The proposed strategy opens a door for developing high‐performance adhesion hydrogels with electrically programmable functions, which are indispensable for various emerging fields like flexible electronics and soft robotics.

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“…This further confirms that catechol group plays an essential role in the wet tissue adhesion. [26][27][28] In order to demonstrate the importance of tissue adhesion of catechol to high hemostatic efficiency, the catechol group on USO-g-gauze is transformed to lower its tissue adhesiveness. Hence, USOFe-g-gauze and USOQu-g-gauze were fabricated.…”

Section: Hemostatic Mechanism Of the Highly Efficient Uso-g-gauzementioning

confidence: 99%

A super-efficient and biosafe hemostatic cotton gauze with controlled balance of hydrophilicity/hydrophobicity and tissue adhesiveness

Zhou

Gao

et al. 2021

Preprint

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Cotton gauze is a widely used topical hemostatic material for bleeding control in military and civil accidents and surgical operations, but its high blood absorption capacity tends to cause extra blood loss of the wounded person, which may increase the risk of shock and death. Therefore, development of rapid hemostatic cotton gauze with less blood loss is of great significance. Herein, we prepared a super-efficient hemostatic cotton gauze whose surface was slightly modified with a catechol compound which features a flexible long hydrophobic alkyl chain terminated with a catechol group. Its hemostatic performance in rat and pig injury models was far superior to standard cotton gauze and Combat GauzeTM. The latter is a well-known commercial gauze for controlling massive hemorrhaging. Additionally, after stoppage of bleeding, the wound sites hardly re-bleed upon the gauze was peeled off. Histological analysis proved that the novel cotton gauze well kept the biosafety of cotton gauze. Interestingly, a similar impressive hemostatic performance was also achieved for chitosan nonwoven gauze modified with the same procedure. Density functional theory calculation and instrumental measurements demonstrate that their extraordinary hemostatic capability is attributable to the highly efficient formation of big and thick primary blood clot made of massive aggregated erythrocytes, due to gauze’s effective controlling of blood movement through its blocking effect from tissue adhesion by catechol, platelet activation by cotton fiber, blood absorption by cotton, and hydrophobic effect from long alkyl chain. The methodology and hemostatic mechanisms presented in this work may open a new avenue for developing highly efficient hemostatic gauzes.

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Mussel foot protein inspired tough tissue-selective underwater adhesive hydrogel

Abstract: Novel underwater tissue-selective adhesive hydrogels with adhesion energy to wet porcine skin of ∼1011 J m−2 were made by bio-mimicking Mfps.

Cited by 167 publications

References 43 publications

Efficient, biosafe and tissue adhesive hemostatic cotton gauze with controlled balance of hydrophilicity and hydrophobicity

Efficient, biosafe and tissue adhesive hemostatic cotton gauze with controlled balance of hydrophilicity and hydrophobicity

Electrically Programmable Interfacial Adhesion for Ultrastrong Hydrogel Bonding

A super-efficient and biosafe hemostatic cotton gauze with controlled balance of hydrophilicity/hydrophobicity and tissue adhesiveness

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