Mussel-inspired adhesive hydrogels for local immunomodulation

Xie, Chaoming; Li, Yazhen; Guo, Xiaochuan; Ding, Yonghui; Li, Xiong; Rao, Shuquan

doi:10.1039/d2qm01232d

Cited by 15 publications

(7 citation statements)

References 185 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Therefore, substantial efforts have been made to design inherent immunomodulatory hydrogels that can induce pro-regenerative macrophage polarization. [19][20][21][22] 3. Design of Hydrogels for Immunomodulation…”

Section: Immunomodulation Opportunities For Tissue Repair and Regener...mentioning

confidence: 99%

Designing Hydrogels for Immunomodulation in Cancer Therapy and Regenerative Medicine

Zhang,

He,

Chen

2023

Advanced Materials

View full text Add to dashboard Cite

The immune system not only acts as a defense against pathogen and cancer cells, but also plays an important role in homeostasis and tissue regeneration. Targeting immune systems is a promising strategy for efficient cancer treatment and regenerative medicine. Current systemic immunomodulation therapies are usually associated with low persistence time, poor targeting to action sites and severe side effects. Due to their ECM‐mimetic nature, tunable properties and diverse bioactivities, hydrogels are intriguing platforms to locally deliver immunomodulatory agents and cells, as well as provide an immunomodulatory microenvironment to recruit, activate and expand host immune cells. In this review, we focus on the design considerations, including polymer backbones, crosslinking mechanisms, physicochemical nature, and immunomodulation‐related components, of the hydrogel platforms. The immunomodulatory effects and therapeutic outcomes in cancer therapy and tissue regeneration of different hydrogel systems are emphasized, including hydrogel depots for delivery of immunomodulatory agents, hydrogel scaffolds for cell delivery, and immunomodulatory hydrogels depending on the intrinsic properties of materials. Finally, the remained challenges in current systems and future development of immunomodulatory hydrogels are discussed.This article is protected by copyright. All rights reserved

show abstract

Section: Immunomodulation Opportunities For Tissue Repair and Regener...mentioning

confidence: 99%

Designing Hydrogels for Immunomodulation in Cancer Therapy and Regenerative Medicine

Zhang,

He,

Chen

2023

Advanced Materials

View full text Add to dashboard Cite

show abstract

“…However, many studies have successfully incorporated synthetic molecules which resemble the catechol structure of DOPA, [102][103][104] the abundant adhesive substance found in the mussel foot proteins, to fabricate tissue-adhesive hydrogels. [105][106][107] Some synthetic chemicals mimicking the polyol structure of mussel adhesives are dopamine (DA), tannic acid (TA), GA, caffeic acid, etc. For example, Montazerian et al developed a Gel-methacryloyl (GelMA)-DA-adhesive hydrogel via photo-cross-linking using different photo-initiators [108] (Figure 4G).…”

Section: Catechol Chemistrymentioning

confidence: 99%

From Adhesion to Detachment: Strategies to Design Tissue‐Adhesive Hydrogels

Ho,

van Hilst,

Cui

et al. 2023

Advanced NanoBiomed Research

View full text Add to dashboard Cite

The use of tissue adhesives dates to 1940s when surgical glues were introduced for wound closure applications. However, current clinically used tissue adhesives (fibrin and cyanoacrylate glues) have limited adhesion strength and biocompatibility issues which restrict their performance in targeted applications. Due to this unmet clinical challenge, there is a need to develop next‐generation tissue adhesives to expand the current limited available options. Another factor that is often overlooked in the field is the consequence of when these tissue adhesives fail while in use in specific applications. In this review, the complications arising from tissue adhesives that have insufficient adhesion strength are covered, where unintentional loosening and detachment can lead to serious complications depending on both the applications and scenarios in which the adhesives are used. Next, the current methodologies employed to design tissue‐adhesive hydrogels targeting specific applications are also collated. Finally, the different strategies to engineer on‐demand removal property of these tissue‐adhesive hydrogels are consolidated, including some perspectives on current challenges and outlooks in this field.

show abstract

“…It has been reported that catechol compounds play a role in the local immune response by virtue of their capacity to scavenge reactive oxygen species. [52][53][54] Collectively, the RAP patch acts as an inhibitor of inflammation in chronic wounds through its antimicrobial and anti-inflammatory properties, providing a promising therapeutic approach for the treatment of chronic inflammatory skin conditions.…”

Section: Proposed Mechanism Of Rap In Chronic Inflammatory Skin Suppr...mentioning

confidence: 99%

Mussel‐Inspired Recombinant Adhesive Protein‐Based Functionalization for Consistent and Effective Antimicrobial Treatment in Chronic Inflammatory Skin Diseases

Kim,

Khaleel

et al. 2023

Advanced Therapeutics

View full text Add to dashboard Cite

Chronic inflammatory skin diseases, characterized by a vicious cycle of infection and hyperinflammation, necessitate consistent and effective antimicrobial treatment of target lesions to achieve practical therapeutic outcomes. Antimicrobial dressing materials offer notable advantages over conventional therapeutic drugs, including ease of application, extended contact time, and targeted antimicrobial action, resulting in enhanced efficacy in breaking the vicious cycle. In line with these advantages, this study aims to develop a plug‐and‐playable recombinant adhesive protein (RAP) inspired by the adhesive properties of marine mussels, serving as a durable and effective surface functionalization strategy. By genetically recombining mussel foot protein with antimicrobial peptides, RAP effectively incorporates antimicrobial properties into biomaterials for treating chronic inflammatory skin diseases. The durable adhesion of RAP ensures long‐lasting antimicrobial functionality on target surfaces, MFP making it a promising approach to inhibit chronic inflammation. In addition, when dip‐coated onto cotton gauze, RAP can be utilized as an antimicrobial patch, effectively suppressing chronic inflammation through the inhibition of bacteria‐induced toll‐like receptor signaling. These findings underscore the potential of nature‐inspired protein‐based surface functionalization of biomaterials as a compelling approach to advance the treatment of chronic inflammatory skin diseases.

show abstract

Mussel-inspired adhesive hydrogels for local immunomodulation

Abstract: The important function of the immune system is to protect the body from foreign pathogens and tumor cells, and to participate in the process of tissue repair and anti-tumor activity...

Cited by 15 publications

References 185 publications

Designing Hydrogels for Immunomodulation in Cancer Therapy and Regenerative Medicine

Designing Hydrogels for Immunomodulation in Cancer Therapy and Regenerative Medicine

From Adhesion to Detachment: Strategies to Design Tissue‐Adhesive Hydrogels

Mussel‐Inspired Recombinant Adhesive Protein‐Based Functionalization for Consistent and Effective Antimicrobial Treatment in Chronic Inflammatory Skin Diseases

Contact Info

Product

Resources

About