Mussel-inspired elastic interpenetrated network hydrogel as an alternative for anti-thrombotic stent coating membrane

Obiweluozor, Francis O.; Maharjan, Bikendra; Emechebe, A. Gladys; Park, Chan Hee; Kim, Cheol Sang

doi:10.1016/j.cej.2018.04.098

Cited by 29 publications

(12 citation statements)

References 63 publications

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“…This reduction in platelet surface coverage was far greater than the amount of reduction observed for recent heparin drug-eluting stents [ 23 , 24 , 26 ], which showed far more platelet adhesion to their modified steel samples as compared to MEG-OH-coated samples, and poorer reduction in adhesion of less than 80% compared to the greater-than-90% adhesion observed for MEG-OH. Additionally, the amount of platelet reduction was greater than that observed for recent graphene surface coatings on steel which display an 80–90% reduction [ 30 , 31 , 32 ], and performed similarly to hydrogel coatings, with a greater-than-90% reduction [ 33 , 34 ]. As such, MEG-OH performs as well or better than the so-called state-of-the-art alternative coatings as it pertains to the prevention of thrombus formation.…”

Section: Resultsmentioning

confidence: 95%

“…These coatings may show greater reduction in platelet adhesion compared to heparin-eluting stents, with some reducing adhesion by 80–90%, but these also show slightly elevated cytotoxicity compared to bare stents. Anti-thrombogenic hydrogel coatings have also seen advances in recent years [ 33 , 34 ], which display reasonable reduction in platelet adhesion to stainless steel with slightly over 90% reduction in platelet adhesion observed.…”

Section: Introductionmentioning

confidence: 99%

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Anti-Thrombogenicity Study of a Covalently-Attached Monolayer on Stent-Grade Stainless Steel

2021

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Implantable devices fabricated from austenitic type 316L stainless steel have been employed significantly in medicine, principally because the material displays excellent mechanical characteristics and corrosion resistance. It is well known, however, that interaction of exposure of such a material to blood can initiate platelet adhesion and blood coagulation, leading to a harmful medical condition. In order to prevent undesirable surface platelet adhesion on biomaterials employed in procedures such as renal dialysis, we developed an ultrathin anti-thrombogenic covalently attached monolayer based on monoethylene glycol silane chemistry. This functions by forming an interstitial hydration layer which displays restricted mobility in the prevention of surface fouling. In the present work, the promising anti-thrombogenic properties of this film are examined with respect to platelet aggregation on 316L austenitic stainless steel exposed to whole human blood. Prior to exposure with blood, all major surface modification steps were examined by X-ray photoelectron spectroscopic analysis and surface free-angle measurement by contact angle goniometry. End-stage anti-thrombogenicity detection after 20 min of blood exposure at 100 s−1, 300 s−1, 600 s−1, 750 s−1, and 900 s−1 shear rates revealed that a significant reduction (>90%) of platelet adhesion and aggregation was achieved for surface-modified steel, compared with untreated material. This result is confirmed by experiments conducted in real time for 60-minute exposure to blood at 100 s−1, 600 s−1, and 900 s−1 shear rates.

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Section: Resultsmentioning

confidence: 95%

Section: Introductionmentioning

confidence: 99%

Anti-Thrombogenicity Study of a Covalently-Attached Monolayer on Stent-Grade Stainless Steel

2021

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“…Effort to improve the efficiency of stent therapy has been going on for decades. From the early generation of bare mental stents (BMS), drug eluting stents (DES) to biodegradable stents (BDS), various of materials [ [28] , [29] , [30] , [31] , [32] , [33] ] and surface coatings [ 30 , [34] , [35] , [36] ] have been investigated together with surface texturing and surface chemistry modifications to improve the stents performance and reduce ISR and LST rate.,.…”

Section: Effects Of Topography and Surface Chemistry On Stentsmentioning

confidence: 99%

“…Bio-originated and biomimetic polymer coatings are other two types of novel and popular coatings for stent applications. Some of these coatings have good performance as stent coatings, such as phospholipid-based coatings [ 103 ], phosphorylcholine-based copolymers [ 104 ] and mussel-inspired hydrogel [ 36 ]. The high biocompatibility and hemocompatibility of these coatings are important properties.…”

Section: Effects Of Topography and Surface Chemistry On Stentsmentioning

confidence: 99%

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Surface engineering and the application of laser-based processes to stents - A review of the latest development

Dong

Pacella

Liu

et al. 2022

Bioactive Materials

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Late in-stent thrombus and restenosis still represent two major challenges in stents’ design. Surface treatment of stent is attracting attention due to the increasing importance of stenting intervention for coronary artery diseases. Several surface engineering techniques have been utilised to improve the biological response in vivo on a wide range of biomedical devices. As a tailorable, precise, and ultra-fast process, laser surface engineering offers the potential to treat stent materials and fabricate various 3D textures, including grooves, pillars, nanowires, porous and freeform structures, while also modifying surface chemistry through nitridation, oxidation and coatings. Laser-based processes can reduce the biodegradable materials' degradation rate, offering many advantages to improve stents’ performance, such as increased endothelialisation rate, prohibition of SMC proliferation, reduced platelet adhesion and controlled corrosion and degradation. Nowadays, adequate research has been conducted on laser surface texturing and surface chemistry modification. Laser texturing on commercial stents has been also investigated and a promotion of performance of laser-textured stents has been proved. In this critical review, the influence of surface texture and surface chemistry on stents performance is firstly reviewed to understand the surface characteristics of stents required to facilitate cellular response. This is followed by the explicit illustration of laser surface engineering of stents and/or related materials. Laser induced periodic surface structure (LIPSS) on stent materials is then explored, and finally the application of laser surface modification techniques on latest generation of stent devices is highlighted to provide future trends and research direction on laser surface engineering of stents.

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Bilayer Scaffolds Synergize Immunomodulation and Rejuvenation via Layer‐Specific Release of CK2.1 and the “Exercise Hormone” Lac‐Phe for Enhanced Osteochondral Regeneration

Liu,

He,

Shen

et al. 2024

Adv Healthcare Materials

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Repairing osteochondral defects necessitates the intricate reestablishment of the microenvironment. The cartilage layer consists of a porous gelatin methacryloyl hydrogel (PGelMA) covalently crosslinked with the chondroinductive peptide CK2.1 via a “linker” acrylate‐PEG‐N‐hydroxysuccinimide (AC‐PEG‐NHS). This layer is optimized for remodeling the senescent microenvironment in the cartilage region, thereby establishing a regenerative microenvironment that supports chondrogenesis. For the bone layer, silk fibroin methacryloyl (SilMA) is coated onto a three dimensional (3D)‐printed 45S5 bioactive glass scaffold (BG scaffold). The “exercise hormone” N‐lactoyl‐phenylalanine (Lac‐Phe) is loaded onto the SilMA, endowing it with diversified functions to regulate the osteogenic microenvironment. Systematic analysis in vitro reveals that PGelMA‐CK2.1 shifts the microenvironment from a pro‐inflammatory into an anti‐inflammatory condition, and alleviates cellular senescence, thus modifying the cartilage microenvironment to improve the recruitment, proliferation and chondral differentiation of bone marrow mesenchymal stem cells (BMSCs). The scaffold bone layer enhances microvascular endothelial cell proliferation, migration, and angiogenic activities, which, couple with increased BMSC recruitment and regulatory mechanisms directing BMSC differentiation, favor a shift in the “osteogenesis–adipogenesis” balance toward enhanced osteogenesis. In vivo, it is found that this biphasic biomimetic scaffold favors simultaneous dual tissue regeneration. This approach facilitates the development of bioactive regenerative scaffolds and holds great potential for clinical application.

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Mussel-inspired elastic interpenetrated network hydrogel as an alternative for anti-thrombotic stent coating membrane

Cited by 29 publications

References 63 publications

Anti-Thrombogenicity Study of a Covalently-Attached Monolayer on Stent-Grade Stainless Steel

Anti-Thrombogenicity Study of a Covalently-Attached Monolayer on Stent-Grade Stainless Steel

Surface engineering and the application of laser-based processes to stents - A review of the latest development

Bilayer Scaffolds Synergize Immunomodulation and Rejuvenation via Layer‐Specific Release of CK2.1 and the “Exercise Hormone” Lac‐Phe for Enhanced Osteochondral Regeneration

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