Mussel-inspired hybrid network hydrogel for continuous adhesion in water

Fu, Yifu; Ren, Pengfei; Wang, Faming; Min, Liang; Hu, Wanjun; Zhou, Naizhen; Zhang, Lu; Zhang, Tianzhu

doi:10.1039/c9tb02863c

Cited by 48 publications

(34 citation statements)

References 41 publications

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“…This extraction or elusion technique is a well-known method to study the cytocompatibility of different types of implants. [57,58] XTT results showed excellent cell viability for the 3D printed substrates both before and after the grafting procedure (Figure 9a,b) demonstrating their high cytocompatibility. For a more intuitive visualization of the cell viability, we further performed the live-dead staining assay on 3T3 cells treated with the extracted DMEM (24 h incubation with the constructs) for 24 h of culture (Figure 9c-f) using staining with fluorescein diacetate, a cell membrane dye indicating live cells (green), and propidium iodide, a DNA stain indicating dead cells (red).…”

Section: Rendering the Stent With Anti-fouling Behaviormentioning

confidence: 96%

A Personalized Multifunctional 3D Printed Shape Memory‐Displaying, Drug Releasing Tracheal Stent

Maity

Mansour

Chakraborty

et al. 2021

Adv Funct Materials

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The ability to engineer custom-made medical devices and to implant them minimally invasively are two important trends in modern surgery. The personalization of the device is achieved by 3D printing it, while the capacity to deploy it minimally invasively harnesses the shape memory behavior displayed by the inks used. This study introduces a 3D printed, shape memorydisplaying tracheal stent based on novel, flexible photo-polymerizable inks comprising polypropylene glycol/polycaprolactone triblocks. This research introduces the in situ welding strategy, whereby thin and flexible layers of the stent are separately printed, sequentially deployed, and then welded together at the tracheal site. By doing so, the insertion profile of the device is dramatically reduced and its flexibility largely increased. Porous stents are 3D printed seeking to prevent mucus plugging. By combining more than one ink, their properties are further fine-tuned. Polyethylene glycol chains are covalently bonded to the stent surface to minimize biofilm formation, an important drawback of current tracheal stents. The in vitro cell viability and cell adhesion behavior of the treated surfaces reveal their compatibility and anti-adhesive behavior. In order to prevent implant-related infections, ciprofloxacin is added to the ink, and released in vitro over time, rendering the stent with antibacterial activity.

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Section: Rendering the Stent With Anti-fouling Behaviormentioning

confidence: 96%

A Personalized Multifunctional 3D Printed Shape Memory‐Displaying, Drug Releasing Tracheal Stent

Maity

Mansour

Chakraborty

et al. 2021

Adv Funct Materials

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show abstract

“…The results of the vibration test show that the G ′ is significantly higher than the G “, thereby indicating that these hydrogels (FT3, FT6, and FT9) and Re‐gel behave more like a viscoelastic gel rather than a viscous fluid (Figure 8c). [ 45 ] Furthermore, G ′ increased with the FT cycles, which indicated that, to a certain extent, the rheological properties of the hydrogels depended on the FT cycles. Ice crystals might be formed and the NFLMP was present in frozen solutions of RHK at temperatures below the eutectic point of the corresponding system.…”

Section: Resultsmentioning

confidence: 97%

Molecular Mechanism of Rabbit Hair Keratin Hydrogel Fabricated via Cryoablation

Wang

Shi

Tian

et al. 2021

Macro Chemistry & Physics

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Keratins are highly attractive natural biomaterials for medical applications due to their inherent self-assembly characteristics and biocompatibility. In this study, the molecular mechanism of rabbit hair keratin (RHK) gelation during cryogelation is investigated and the influence of cryogelation parameters on the gelation of keratin is systematically evaluated. Re-xidation of free cysteine thiols and formation of hydrogen bond are determined to be the main stabilizing forces in self-assembly of RHK gel, and ionic bonds are found to affect the uniformity of keratin hydrogels. pH affects the gelation by changing the electrostatic interaction between keratin molecules. Keratin will accumulate when pH is too low, but the stability of keratin hydrogels becomes worse when the pH is too high. With successive freezing-thawing (FT) cycles, the storage modulus of RHK cryogels substantially improved from 240.66 Pa at FT cycle 3 to 2483.3 Pa at FT cycle 9. Maintaining the balance of the interactive force between keratin molecules and between keratin molecules and water molecules is the basis of preparing uniform and stable keratin hydrogels.

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“…Fu et al [ 44 ] designed a hybrid system, based on CMC, to be used as an underwater adhesion hydrogel. For this purpose, oxidised CMC (OCMC) was prepared using the periodate oxidation method, and subsequently modified by combination with DA via carbodiimide (EDC/NHS) crosslinker chemistry (average DS = 15%).…”

Section: Resultsmentioning

confidence: 99%

Mussel-Inspired Catechol Functionalisation as a Strategy to Enhance Biomaterial Adhesion: A Systematic Review

et al. 2021

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Biomaterials have long been explored in regenerative medicine strategies for the repair or replacement of damaged organs and tissues, due to their biocompatibility, versatile physicochemical properties and tuneable mechanical cues capable of matching those of native tissues. However, poor adhesion under wet conditions (such as those found in tissues) has thus far limited their wider application. Indeed, despite its favourable physicochemical properties, facile gelation and biocompatibility, gellan gum (GG)-based hydrogels lack the tissue adhesiveness required for effective clinical use. Aiming at assessing whether substitution of GG by dopamine (DA) could be a suitable approach to overcome this problem, database searches were conducted on PubMed® and Embase® up to 2 March 2021, for studies using biomaterials covalently modified with a catechol-containing substituent conferring improved adhesion properties. In this regard, a total of 47 reports (out of 700 manuscripts, ~6.7%) were found to comply with the search/selection criteria, the majority of which (34/47, ~72%) were describing the modification of natural polymers, such as chitosan (11/47, ~23%) and hyaluronic acid (6/47, ~13%); conjugation of dopamine (as catechol “donor”) via carbodiimide coupling chemistry was also predominant. Importantly, modification with DA did not impact the biocompatibility and mechanical properties of the biomaterials and resulting hydrogels. Overall, there is ample evidence in the literature that the bioinspired substitution of polymers of natural and synthetic origin by DA or other catechol moieties greatly improves adhesion to biological tissues (and other inorganic surfaces).

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Mussel-inspired hybrid network hydrogel for continuous adhesion in water

Abstract: The mussel-inspired catechol-based strategy has been widely used in the development of adhesives.

Cited by 48 publications

References 41 publications

A Personalized Multifunctional 3D Printed Shape Memory‐Displaying, Drug Releasing Tracheal Stent

A Personalized Multifunctional 3D Printed Shape Memory‐Displaying, Drug Releasing Tracheal Stent

Molecular Mechanism of Rabbit Hair Keratin Hydrogel Fabricated via Cryoablation

Mussel-Inspired Catechol Functionalisation as a Strategy to Enhance Biomaterial Adhesion: A Systematic Review

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