Mussel-inspired load bearing metal–polymer glues

Prevention of postsurgery infection and promotion of biointegration are the key factors to achieve long-term success in orthopedic implants. Localized delivery of antibiotics and bioactive molecules by the implant surface serves as a promising approach toward these goals. However, previously reported methods for surface functionalization of the titanium alloy implants to load bioactive ingredients suffer from time-consuming complex processes and lack of long-term stability. Here, we present the design and characterization of an adhesive, osteoconductive, and antimicrobial hydrogel coating for Ti implants. To form this multifunctional hydrogel, a photo-cross-linkable gelatin-based hydrogel was modified with catechol motifs to enhance adhesion to Ti surfaces and thus promote coating stability. To induce antimicrobial and osteoconductive properties, a short cationic antimicrobial peptide (AMP) and synthetic silicate nanoparticles (SNs) were introduced into the hydrogel formulation. The controlled release of AMP loaded in the hydrogel demonstrated excellent antimicrobial activity to prevent biofilm formation. Moreover, the addition of SNs to the hydrogel formulation enhanced osteogenesis when cultured with human mesenchymal stem cells, suggesting the potential to promote new bone formation in the surrounding tissues. Considering the unique features of our implant hydrogel coating, including high adhesion, antimicrobial capability, and the ability to induce osteogenesis, it is believed that our design provides a useful alternative method for bone implant surface modification and functionalization.

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“…This comparison highlighted the feasibility of introducing catechol motifs to enhance hydrogel–metal adhesion. 31 …”

Section: Resultsmentioning

confidence: 99%

Mussel-Inspired Multifunctional Hydrogel Coating for Prevention of Infections and Enhanced Osteogenesis

Cheng

Yue

Kazemzadeh-Narbat

et al. 2017

ACS Appl. Mater. Interfaces

223

125

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“…Since this discovery, researchers have focused on incorporating DOPA into polymers for a variety of adhesive applications [18][19][20][21]. Stepuk and collaborators introduced a mussel-inspired synthetic adhesive based on the copolymer of dopamine methacrylamide (DMA) with methyl methacrylate (MMA), which is a copolymer with catechol functionality [22]. When this coating was subjected to a macroscopic load, effective transfers of mechanical stress from the metal matrix to the polymer cement improved the strength of conventional PMMA cements bonded to titanium and aluminum.…”

Section: Introductionmentioning

confidence: 99%

Bioinspired dopamine-conjugated polyaspartamide as a novel and versatile adhesive material

Wang¹,

Jeon²,

Bhang³

et al. 2017

Express Polym. Lett.

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Abstract. Biomimetic dopamine-conjugated polyaspartamides as novel adhesive materials were synthesized and characterized. These modified polyaspartamides contain three different groups combined with dopamine (DOPA), i.e., γ-amino butyric acid (GABA), ethanolamine (EA) and octylamine (OA), which are referred to as PolyAspAm (DOPA/GABA), PolyAspAm(DOPA/EA) and PolyAspAm(DOPA/OA), respectively. These three water-swollen polymer glues show good adhesion (0.1~0.4 MPa) with various daily-life materials (aluminum foil, glass and paper) as well as some plastic substrates (PET and PMMA). Compared to the polymers with more hydrophilic groups (GABA and EA), the polymer glue with the hydrophobic alkyl group (OA) exhibited higher adhesive strength values on most substrates. In addition, when applied to biological porcine skin, these glues demonstrated adhesion of values of 15~20 kPa with EA-and OA-conjugated polymers. These results suggest the great potential of dopamine-modified polyaspartamides as versatile and efficient polymeric glues for industrial and biomedical applications.

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“…The catechols can strongly coordinate with metal ions, such as Fe 3+ , Al 3+ , Mg 2+ , and Zn 2+ . Studies have shown that several catechols can coordinate with a metal ion to form a coordination point to promote bulk cross‐linking density .…”

Section: Resultsmentioning

confidence: 99%

Synthesis and Adhesive Property Study of a Mussel-Inspired Adhesive Based on Poly(vinyl alcohol) Backbone

et al. 2017

Macromol. Chem. Phys.

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In this study, an effective way is presented to synthesize a mussel‐inspired adhesive from two inexpensive commercially available materials: polyvinyl alcohol (PVA) and 3,4‐dihydroxybenzoic acid via the esterification reaction and deprotection technology. This bioinspired adhesive exhibits good bonding ability on metal, glass, plastic, and wood, and the maximum bonding strength can be up to 4.0 MPa at dry conditions on glass substrate. Meanwhile, this adhesive can also be used as a wet/underwater adhesive. Such a PVA‐based bioinspired adhesive may be used as a potential candidate for applications in industrial field.

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Mussel-inspired load bearing metal–polymer glues

Abstract: A mussel-inspired synthetic adhesive based on dopamine containing methacrylate copolymers was developed to bond polymers to metal surfaces at an adhesion strength of up to 20 MPa for bulk samples.

Cited by 57 publications

References 27 publications

Mussel-Inspired Multifunctional Hydrogel Coating for Prevention of Infections and Enhanced Osteogenesis

Mussel-Inspired Multifunctional Hydrogel Coating for Prevention of Infections and Enhanced Osteogenesis

Bioinspired dopamine-conjugated polyaspartamide as a novel and versatile adhesive material

Synthesis and Adhesive Property Study of a Mussel-Inspired Adhesive Based on Poly(vinyl alcohol) Backbone

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