Mussel-inspired nanoparticle composite hydrogels for hemostasis and wound healing

Abstract

Uncontrolled hemorrhage caused by trauma can easily lead to death. Efficient and safe hemostatic materials are an urgent and increasing need for hemostatic research. Following a trauma, wound healing is induced by various cellular mechanisms and proteins. Hemostatic biomaterials that can not only halt bleeding quickly but also provide an environment to promote wound healing have been the focus of research in recent years. Mussel-inspired nanoparticle composite hydrogels have been propelling the development of hemostatic materials owing to their unique advantages in adhesion, hemostasis, and bacteriostasis. This review summarizes the hemostatic and antimicrobial fundamentals of polydopamine (PDA)-based nanomaterials and emphasizes current developments in hemorrhage-related PDA nanomaterials. Moreover, it briefly discusses safety concerns and clinical application problems with PDA hemostatic nanomaterials.

Facile Solvent-Free Fabrication of All-Small-Molecule Supramolecular Photothermal Bioadhesive for Sutureless Wound Closure

“…This might be attributed to the fact that polyphenol groups in proanthocyanidins interact with active residues of proteins or polysaccharides in the blood, thus accelerating blood clotting. In addition, a lot of negative charges in polyphenols could activate coagulation factor XII in the body, thereby triggering its own coagulation cascade and improving its hemostatic ability Figure c shows qualitative photographs of hemorrhage.…”

“…In addition, a lot of negative charges in polyphenols could activate coagulation factor XII in the body, thereby triggering its own coagulation cascade and improving its hemostatic ability. 56 Figure 7c shows qualitative photographs of hemorrhage. As can be seen from Figure 7d, the blood loss in the blank control group (2361.50 ± 38.89 mg) was significantly higher than that in the gauze (1082.00 ± 16.97 mg) and the TPFe bioadhesive groups (934.00 ± 78.08 mg), indicating that the TPFe bioadhesive had good hemostatic performance.…”

Glucose oxidase and metal catalysts combined tumor synergistic therapy: mechanism, advance and nanodelivery system

“…Polydopamine was used as a surface-modified PTT therapeutic material due to its good biocompatibility and photothermal conversion properties [ 112 ]. Hyaluronic acid targets the highly expressed CD44 receptor in tumor cells, aiding NPs in localizing to tumor regions [ 113 ]. In experiments, increased · OH concentration and significantly decreased glucose concentration confirmed the efficient ST/CDT achieved by iron ions working with GOx.…”

3D shape morphing of stimuli-responsive composite hydrogels

“…In recent years, composite hydrogels, an effective way to fabricate smart hydrogels, attract significant attention due to their numerous advantages and unique properties that allow them to overcome some limitations, including low strength, limited functionalities, and isotropic volume change, inherent to traditional hydrogels. 19,21,22 Typically, composite hydrogels involve combining a hydrogel matrix with other materials, such as inorganic fillers, organic compounds, or other polymers, significantly enhancing their functionality and performance. One key advantage of composite hydrogels is their improved mechanical properties.…”