2020
DOI: 10.1021/acsbiomaterials.9b01864
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Mussel-Inspired Naturally Derived Double-Network Hydrogels and Their Application in 3D Printing: From Soft, Injectable Bioadhesives to Mechanically Strong Hydrogels

Abstract: As promising candidates for tissue engineering, hydrogels possess great potential, especially in bioadhesives and load-bearing tissue scaffolds. However, a strategy for synthesizing hydrogels that could achieve the above requirements remains a challenge. Here, a mussel-inspired naturally derived double-network (DN) hydrogel composed of a special combination of two well-characterized natural polymers, hyaluronic acid and alginate, is presented. The key features are its two-step synthesis strategy, which generat… Show more

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Cited by 41 publications
(31 citation statements)
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“…The rheological properties of hydrogel precursors play a crucial role in their application as injectable bioinks in 3D printing. [31,44] As shown in Figure 6b, the viscosity of HAMA and Alg was lower than that of nanoclay at a low shear rate. However, the viscosity of the nanoclay and its mixture with HAMA and Alg decreased significantly with increasing shear rate, thus demonstrating typical shear-thinning properties.…”
Section: Extrusion Path: Synthesis and Characterization Of The 1d Filaments And 3d Constructsmentioning
confidence: 86%
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“…The rheological properties of hydrogel precursors play a crucial role in their application as injectable bioinks in 3D printing. [31,44] As shown in Figure 6b, the viscosity of HAMA and Alg was lower than that of nanoclay at a low shear rate. However, the viscosity of the nanoclay and its mixture with HAMA and Alg decreased significantly with increasing shear rate, thus demonstrating typical shear-thinning properties.…”
Section: Extrusion Path: Synthesis and Characterization Of The 1d Filaments And 3d Constructsmentioning
confidence: 86%
“…This phenomenon has been commonly observed in hydrogels based on ionic crosslinking networks. [31] Besides, the addition of hyaluronidase could degrade the backbone of HAMA, which leads to the disintegration of covalent HAMA crosslinking networks. [55] Furthermore, Van Gieson's staining of calvarial undecalcified sections was performed to determine the degradation of NIDN hydrogels in vivo and tissue regeneration induced by this process (Figure S16, Supporting Information).…”
Section: Biocompatibility Of Nidn Hydrogels and Their Application In Calvarial Defect Reconstructionmentioning
confidence: 99%
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“…Of particular interest, smart hydrogels have been extensively utilized for the sustained release of pharmaceutics with controlled pH [7][8][9], electric fields [10], osmosis [11], molecular structure [12,13], and temperature [14][15][16][17], regulating their swelling properties. In the meantime, numerous studies have been performed to improve the physical, mechanical, and biomedical properties of hydrogels, making them attractive for a wide range of applications [18,19].…”
Section: Introductionmentioning
confidence: 99%