Mussel-inspired “plug-and-play” hydrogel glue for postoperative tumor recurrence and wound infection inhibition

Li, Zimu; Yang, Li; Zhang, Dan; Wang, Wenyan; Huang, Qili; Liu, Qingyun; Shi, Kexin; Yu, Ying‐Hui; Gao, Nansha; Chen, Hongzhong; Jiang, Shiwei; Xie, Zhongjian; Zeng, Xiaowei

doi:10.1016/j.jcis.2023.07.154

Cited by 18 publications

(11 citation statements)

References 49 publications

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“…It can seamlessly integrate with various cancer imaging and treatment techniques, thereby enhancing its effectiveness. 26,27 It is worth noting that traditional treatment methods like surgery, chemotherapy, and radiotherapy have limitations. Surgery might leave residual disease and cause harm to nearby tissue and organs, diminishing its efficacy.…”

Section: Introductionmentioning

confidence: 99%

“…Utilizing PTT can potentially eliminate early‐stage cancer cells without the need for invasive interventions. It can seamlessly integrate with various cancer imaging and treatment techniques, thereby enhancing its effectiveness 26,27 …”

Section: Introductionmentioning

confidence: 99%

“…These groups enable PDA‐NPs to chelate metal ions directly, eliminating the need for external chelating agents and making them promising candidates for use as T1 MRI CAs 34,35 . Moreover, PDA shows potential as a PTT agent due to its biocompatibility and ability to convert laser photons into heat energy 27–36 . However, there is a need to address targeting issues to optimize diagnosis and treatment outcomes.…”

Section: Introductionmentioning

confidence: 99%

“…34,35 Moreover, PDA shows potential as a PTT agent due to its biocompatibility and ability to convert laser photons into heat energy. [27][28][29][30][31][32][33][34][35][36] However, there is a need to address targeting issues to optimize diagnosis and treatment outcomes. Different functionalization approaches, including polyethylene glycol (PEG)functionalized PDA nanoparticles [34][35][36][37]38 for imaging and therapy, folate-functionalized PDA nanoparticles, 39 and a PDA theranostics nanoprobe 34 have been used, but they have limitations like complexity, high cost, and time-consuming processes.…”

Section: Introductionmentioning

confidence: 99%

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Targeted theranostics agent based on polydopamine/hyaluronic acid nanoparticles for MRI and photothermal therapy

Orangi,

Delavari H.,

Davaran

et al. 2023

Polymers for Advanced Techs

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Theranostics based on magnetic resonance imaging (MRI) and photothermal therapy can provide high‐resolution imaging with the minimum side effect of cancer treatment. In this research, polydopamine nanoparticles (PDA‐NPs) are synthesized and functionalized with hyaluronic acid (HA) as a cancer‐targeting theranostics agent. The synthesis of PDA‐NPs with an average size of 25 nm is confirmed by field emission scanning electron microscope, and the functionalization of PDA‐NPs with HA is confirmed by ultraviolet–visible spectroscopy and Fourier transform infrared spectroscopy. The highest longitudinal relaxation rate (r1) is observed at the Fe to PDA weight ratio of 0.25 by MRI analysis. MTT results confirm that the PDA/HA‐NPs to Fe ion concentration of 6 μg mL−1 are not toxic (cell viability, 80%–95%). The result of immunocytochemistry analysis shows the binding of 78% of PDA/HA‐NPs to the human bone marrow mesenchymal stem cells with CD44 antigens. Finally, PDA/HA‐NPs are irradiated by an 808 nm laser to investigate their photothermal property. The specific absorption rate of PDA/HA‐NPs at a concentration of 0.4 mg mL−1 with an iron ratio of 0.25 is determined as 107.95 W g−1 when irradiated with a laser of 500 mW cm−2 power density.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Targeted theranostics agent based on polydopamine/hyaluronic acid nanoparticles for MRI and photothermal therapy

Orangi,

Delavari H.,

Davaran

et al. 2023

Polymers for Advanced Techs

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“…This method facilitated targeted delivery and controlled release of the hydrophobic drug PTX. Because polydopamine (PDA) possesses multiple advantages such as strong adhesion, responsive degradability under weak acid conditions, favorable photothermal effect and biocompatibility, etc., − we thus employed the oxidative self-polymerization of dopamine to form a thin film shell on the surface of PTX-PHBV NPs, serving as a pH-responsive switch for drug release. Folate receptor alpha (FOLR1) levels have been found to be elevated in tumors of epithelial origin compared to normal tissue.…”

Section: Introductionmentioning

confidence: 99%

Enhancing Targeted Therapy in Hepatocellular Carcinoma through a pH-Responsive Delivery System: Folic Acid-Modified Polydopamine-Paclitaxel-Loaded Poly(3-hydroxybutyrate-co-3-hydroxyvalerate) Nanoparticles

Wu,

Wang,

Peng

et al. 2023

Mol. Pharmaceutics

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Currently, there is an inherent contradiction between the multifunctionality and excellent biocompatibility of anticancer drug nanocarriers, which limits their application. Therefore, to overcome this limitation, we aimed to develop a biocompatible drug delivery system for the treatment of hepatocellular carcinoma (HCC). In this study, we employed poly(3-hydroxybutyrate-co-3hydroxyvalerate) (PHBV) as the fundamental framework of the nanocarrier and utilized the emulsion solvent evaporation method to fabricate nanoparticles loaded with paclitaxel (PTX), known as PTX-PHBV NPs. To enhance the tumortargeting capability, a dopamine self-polymerization strategy was employed to form a pH-sensitive coating on the surface of the nanoparticles. Then, folic acid (FA)-targeting HCC was conjugated to the nanoparticles with a polydopamine (PDA) coating by using the Michael addition reaction, resulting in the formation of HCC-targeted nanoparticles

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Recent Advances in Biomacromolecule‐Reinforced 2D Material (2DM) Hydrogels: From Interactions, Synthesis, and Functionalization to Biomedical Applications

Gu,

Cui,

et al. 2024

Adv Funct Materials

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Regenerative biomedicine has emerged as a forefront area in medical research, heralding a new era of therapeutic strategies. This review delineates the integration of 2D materials (2DMs) within the area of biomedical engineering, leveraging their superior physicochemical attributes for enhance biomedical outcomes. The synergistic interaction between biomacromolecules and 2DMs is explored, demonstrating their potential to mitigate the limitations inherent to each while simultaneously augmenting their beneficial properties. In particular, incorporating 2DMs into hydrogels highlights their capability to enhance the mechanical strength of hydrogels, providing a biomimetic scaffold for tissue engineering regeneration and cancer diagnosis and therapy. An overview of the synthetic methodologies are provided for 2DMs, elucidating their interaction dynamics with biomacromolecules. The review primarily concentrates on the applications of biomacromolecule‐reinforced 2DM hydrogels across various biomedical fields, including bone tissue engineering, wound healing, neural tissue engineering, cardiac tissue engineering, as well as in the delivery of drugs and genes, cancer therapy, and biosensing technologies. Finally, the review discusses the existing challenges and future outlook for developing and using biomacromolecule‐reinforced 2DM hydrogels, underlining their transformative potential in regenerative medicine.

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Mussel-inspired “plug-and-play” hydrogel glue for postoperative tumor recurrence and wound infection inhibition

Cited by 18 publications

References 49 publications

Targeted theranostics agent based on polydopamine/hyaluronic acid nanoparticles for MRI and photothermal therapy

Targeted theranostics agent based on polydopamine/hyaluronic acid nanoparticles for MRI and photothermal therapy

Enhancing Targeted Therapy in Hepatocellular Carcinoma through a pH-Responsive Delivery System: Folic Acid-Modified Polydopamine-Paclitaxel-Loaded Poly(3-hydroxybutyrate-co-3-hydroxyvalerate) Nanoparticles

Recent Advances in Biomacromolecule‐Reinforced 2D Material (2DM) Hydrogels: From Interactions, Synthesis, and Functionalization to Biomedical Applications

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