Mussel-inspired polymer with catechol and cationic Lys functionalities for dentin wet bonding

Hu, Zunhan; Wu, Wenzhen; Yu, Mengshi; Wang, Zhi; Yang, Zhenyu; Xing, Xiaodong; Chen, Xiaofang; L, Niu; Fan, Yu; Xiao, Yuhong; Chen, Ji Hua

doi:10.1016/j.mtbio.2022.100506

Cited by 6 publications

(7 citation statements)

References 58 publications

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“…Researchers have proposed corresponding solutions for either insufficient penetration of adhesives or bacterial infections, such as ethanol wet bonding, 13 hybrid layer remineralization, 14 developing new primer 15,16 and new etching agents, 17,18 constructing antibacterial monomers, 19–21 and incorporating nanoparticles with antibacterial properties. 22 However, none of these strategies challenged the two big problems which made the efforts less effective, as the region unprotected by adhesive is just the bacterial region and other stimulates attacked.…”

Section: Introductionmentioning

confidence: 99%

A polyhexamethylene biguanide-assembly assisted strategy of dentin bonding greatly promotes bonding effects and caries treatment

Shu,

Chen,

Zhang

et al. 2023

J. Mater. Chem. B

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Section: Introductionmentioning

confidence: 99%

A polyhexamethylene biguanide-assembly assisted strategy of dentin bonding greatly promotes bonding effects and caries treatment

Shu,

Chen,

Zhang

et al. 2023

J. Mater. Chem. B

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“…This study differs from Degen et al where the adhesion force was dictated more by the film thickness than potential cation−π interactions. 34 In addition to these hydrogels, cationic catechol-based systems have also been developed for antimicrobial coatings, 35 antiinfective materials, 36 dental adhesives, 37 and wound dressings. 38 At this point, it appears that the influence of cations upon adhesion is rather complex, seems to vary between systems, changes with differing methods of study, and a clear picture has yet to emerge.…”

Section: Previous Studies Of Bulk Polymers and Adhesionmentioning

confidence: 99%

Positive Charge Influences on the Surface Interactions and Cohesive Bonding of a Catechol-Containing Polymer

Garcia-Rodriguez,

Wilker

2024

ACS Appl. Mater. Interfaces

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Achieving robust underwater adhesion remains challenging. Through generations of evolution, marine mussels have developed an adhesive system that allows them to anchor onto wet surfaces. Scientists have taken varied approaches to developing mussel-inspired adhesives. Mussel foot proteins are rich in lysine residues, which may play a role in the removal of salts from surfaces. Displacement of water and ions on substrates could then enable molecular contact with surfaces. The necessity of cations for underwater adhesion is still in debate. Here, we examined the performance of a methacrylate polymer containing quaternary ammonium and catechol groups. Varying amounts of charge in the polymers were studied. As opposed to protonated amines such as lysine, quaternary ammonium groups offer a nonreactive cation for isolating effects from only charge. Results shown for dry bonding demonstrated that cations tended to decrease bulk cohesion while increasing surface interactions. Stronger interactions at surfaces, along with weaker bulk bonding, indicate that cations decreased the cohesive forces. When under salt water, overall bulk adhesion also dropped with higher cation loadings. Surface attachment under salt water also dropped, indicating that the polymer cations could not displace surface waters or sodium ions. Salt did, however, appear to shield bulk cation−cation repulsions. These studies help to distinguish influences upon bulk cohesion from attachment at surfaces. The roles of cations in adhesion are complex, with both cohesive and surface bonding being relevant in different ways, sometimes even working in opposite directions.

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“…Efficient polymerization of a dental adhesive is primordial for good bonding performance. The experimental Zn-PDA@SiO 2 primers were mixed with the CSE adhesive resin "Bond" at a ratio of 1:9 [23][24] to mimic the effect of the experimental primer (clinically) applied prior to the adhesive resin (and eventually mixed with the adhesive resin) on the polymerization efficiency of the two-step adhesive. DC measurement revealed no statistical differences between any of the groups (Figure 5E), indicating that the addition of different concentrations of Zn-PDA@SiO 2 (1, 3, and 5 wt%) did not affect polymerization of the adhesive monomers.…”

Section: Enhanced Dental-bonding Stability By the Zn-pda@sio 2 -Incor...mentioning

confidence: 99%

“…[22] Previous research demonstrated that dopamine methacrylamide (DMA) pretreatment and catechol-and Lys-functionalized polymerizable polymer (catechol-Lys-methacrylate [CLM]) can improve dentinbonding durability. [23][24] However, the antibacterial activity and in vivo biosafety of mussel-inspired materials remain equally highly important. As reported, PDA plays a significant role in suppressing bacterial protein adsorption [25] and Zn ions stimulate initial cell adhesion and proliferation, [26] thereby potentially benefitting the antibacterial ability and biocompatibility of Zn-PDA complexes.…”

Section: Introductionmentioning

confidence: 99%

High‐Performance Bioinspired Microspheres for Boosting Dental Adhesion

Yao,

Liang,

et al. 2024

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Dental adhesives are widely used in daily practice for minimally invasive restorative dentistry but suffer from bond degradation and biofilm attack. Bio‐inspired by marine mussels having excellent surface‐adhesion capability and high chemical affinity of polydopamine (PDA) to metal ions, herein, experimental zinc (Zn)‐containing polydopamine‐based adhesive formulation, further being referred to as “Zn–PDA@SiO2”‐incorporated adhesive is proposed as a novel dental adhesive. Different Zn contents (5 and 10 mm) of Zn–PDA@SiO2 are prepared. Considering the synergistic effect of Zn and PDA, Zn–PDA@SiO2 not only presents excellent antibacterial potential and notably inhibits enzymatic activity (soluble and matrix‐bound proteases), but also exhibits superior biocompatibility and biosafety in vitro/vivo. The long‐term bond stability is substantially improved by adding 5 wt% 5 mm Zn–PDA@SiO2 to the primer. The aged bond strength of the experimentally formulated dental adhesives applied in self‐etch (SE) bonding mode is 1.9 times higher than that of the SE gold‐standard adhesive. Molecular dynamics calculations indicate the stable formation of covalent bonds, Zn‐assisted coordinative bonds, and hydrogen bonds between PDA and collagen. Overall, this bioinspired dental adhesive provides an avenue technology for innovative biomedical applications and has already revealed promising perspectives for dental restorative dentistry.

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Mussel-inspired polymer with catechol and cationic Lys functionalities for dentin wet bonding

Cited by 6 publications

References 58 publications

A polyhexamethylene biguanide-assembly assisted strategy of dentin bonding greatly promotes bonding effects and caries treatment

A polyhexamethylene biguanide-assembly assisted strategy of dentin bonding greatly promotes bonding effects and caries treatment

Positive Charge Influences on the Surface Interactions and Cohesive Bonding of a Catechol-Containing Polymer

High‐Performance Bioinspired Microspheres for Boosting Dental Adhesion

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