Mussel mimetic tissue adhesive for fetal membrane repair: initial in vivo investigation in rabbits

Kiveliö, Anna-Sofia; DeKoninck, Philip; Perrini, Michela; Brubaker, Carrie E.; Messersmith, Phillip B.; Mazza, Edoardo; Deprest, Jan; Zimmermann, Roland; Ehrbar, Martin; Ochsenbein-Koelble, N.

doi:10.1016/j.ejogrb.2013.09.003

Cited by 50 publications

(55 citation statements)

References 16 publications

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“…Indeed, previous studies showing the deposition of hydrogel materials or blood coagulation-derived materials lacked a controlled method specifically designed for this matter [9, 12, 15-17, 20, 34]. The deliberate choice of diverse sealing materials -2-component glues like fibrin or the promising mussel glue [23][24][25][26] and Histoacryl ® -was done to demonstrate the compatibility of our device with materials of different natures and to highlight the relevance of our method for the testing of those injectable candidates. As follows, we discuss more in detail the elements that make the device presented here a serious option to be considered for the application of sealing or even healing agents at the site of fetal membrane puncture.…”

Section: Discussionmentioning

confidence: 99%

“…Indeed, this glue showed good sealing potential in vitro [24,26], ex vivo [25], and in rabbit models in vivo [23].…”

Section: Introductionmentioning

confidence: 91%

“…More recently, the development of mussel-inspired adhesives working in wet environments brought new hopes for the efficient closure of the fetal membrane [23][24][25]. Indeed, this glue showed good sealing potential in vitro [24,26], ex vivo [25], and in rabbit models in vivo [23].…”

Section: Introductionmentioning

confidence: 99%

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Minimally Invasive Surgical Device for Precise Application of Bioadhesives to Prevent iPPROM

et al. 2018

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Introduction: The benefits of endoscopic fetal surgery are deteriorated by the high risk of iatrogenic preterm prelabor rupture of fetal membranes (iPPROM). While previous studies have reported good sealing candidates to prevent membrane rupture, the delivery of these materials to the location of membrane puncture remains unsolved. Materials and Methods: We describe an approach to apply sealing materials onto the amnion through the fetoscopy port. We developed a device composed of an umbrella-shaped polyester coated nitinol mesh and an applicator. The spontaneously unfolding umbrella is pushed through the port, pulled against the amnion, and glued onto the amnion defect site. We tested the adhesion strength of multiple glues and tested the feasibility and reproducibility of this fetal membrane sealing approach in an ex vivo model. Results: The umbrella unfolded and was well positioned in all tests (n = 18). When applied via the fetoscopy port, umbrellas were successfully glued onto the fetal membrane, and all of them completely covered the defect (n = 5). The mean time needed for the whole procedure was 3 min. Discussion: This study is a proof of concept presenting a potential future solution for the precise local application of bioadhesives for the prevention of iPPROM.

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Section: Discussionmentioning

confidence: 99%

“…Indeed, this glue showed good sealing potential in vitro [24,26], ex vivo [25], and in rabbit models in vivo [23].…”

Section: Introductionmentioning

confidence: 91%

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Minimally Invasive Surgical Device for Precise Application of Bioadhesives to Prevent iPPROM

et al. 2018

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“…We were unable to systematically study this in our cohort. Some studies have used animal models to find different substrates (fibrin glue, mussel-mimetic glue, and decellularized amnion scaffold) [20,21] to seal the membranes with promising results. Unfortunately, this has not translated into clinical practice thus far.…”

Section: Discussionmentioning

confidence: 99%

Iatrogenic Preterm Premature Rupture of Membranes after Fetoscopic Laser Ablative Surgery

et al. 2014

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Introduction: To describe the incidence and risk factors for iatrogenic premature preterm rupture of membranes (iPPROM) after fetoscopic laser surgery for the twin-to-twin-transfusion syndrome. Materials and Methods: This is a retrospective review of all patients who have undergone fetoscopic laser surgery at a single fetal treatment center since 2000. We defined iPPROM as spontaneous rupture of membranes before the onset of labor prior to 34 weeks of gestation. The iPPROM cohort was compared to the cohort without iPPROM for several preoperative, operative, and delivery characteristics. Results: Ninety-two consecutive patients were reviewed. The overall rate of iPPROM was 18.5% (n = 17). The rates of iPPROM within 1 and 4 weeks were 5.4 and 10.9%, respectively. The median interval from surgery to delivery was significantly shorter in the iPPROM group (21 vs. 62 days, p = 0.01). The mean gestational age at delivery (27.0 vs. 31.1 weeks, p = 0.02) was lower in the iPPROM group. No other characteristics studied differed significantly between the groups. Discussion: The incidence of iPPROM was substantially lower than in recent multicenter reports; however, no risk factors of iPPROM could be identified. Whether this is related to variations in surgical or anesthetic management will require further investigation.

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“…It has been shown surface chemistry modification of these nanoparticles can enhance particle adsorption to the tissues and form strong bonding between them [22, 23]. In addition, tissue adhesives with antibacterial capabilities can be formed through the incorporation of antimicrobial nanoparticles or hemostatic bioadhesives can be engineered by encapsulation of active nanoparticles in the adhesives [86]. Novel bioadhesives have been also developed for controlled drug-delivery [4, 87, 88].…”

Section: Nanoparticle Incorporated Surgical Materialsmentioning

confidence: 99%

Surgical materials: Current challenges and nano-enabled solutions

et al. 2014

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Surgical adhesive biomaterials have emerged as substitutes to sutures and staples in many clinical applications. Nano-enabled materials containing nanoparticles or having a distinct nanotopography have been utilized for generation of a new class of surgical materials with enhanced functionality. In this review, the state of the art in the development of conventional surgical adhesive biomaterials is critically reviewed and their shortcomings are outlined. Recent advancements in generation of nano-enabled surgical materials with their potential future applications are discussed. This review will open new avenues for the innovative development of the next generation of tissue adhesives, hemostats, and sealants with enhanced functionality for various surgical applications.

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Mussel mimetic tissue adhesive for fetal membrane repair: initial in vivo investigation in rabbits

Cited by 50 publications

References 16 publications

Minimally Invasive Surgical Device for Precise Application of Bioadhesives to Prevent iPPROM

Minimally Invasive Surgical Device for Precise Application of Bioadhesives to Prevent iPPROM

Iatrogenic Preterm Premature Rupture of Membranes after Fetoscopic Laser Ablative Surgery

Surgical materials: Current challenges and nano-enabled solutions

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