Mussel oligopeptides ameliorate cognition deficit and attenuate brain senescence in d-galactose-induced aging mice

Zhou, Yue; Dong, Ying; Qi, Xu; He, Yuanqing; Tian, Shi-Lei; Zhu, Shuyun; Zhu, Ying; Dong, Xiuping

doi:10.1016/j.fct.2013.06.009

Cited by 41 publications

(20 citation statements)

References 49 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This in turn can lead to increased malondialdehyde (MDA) levels and decreased superoxide dismutase (SOD) and glutathione peroxidase (GSH-px) activities [ 9 – 11 ]. Its administration in rodents also has been reported to cause neurobehavioral changes including cognition and motor impairment; reduced neurogenesis; neurodegeneration; and caspase-dependent apoptosis and mitochondrial dysfunction [ 12 ].…”

Section: Introductionmentioning

confidence: 99%

D-galactose-induced brain ageing model: A systematic review and meta-analysis on cognitive outcomes and oxidative stress indices

et al. 2017

View full text Add to dashboard Cite

Animal models are commonly used in brain ageing research. Amongst these, models where rodents are exposed to d-galactose are held to recapitulate a number of features of ageing including neurobehavioral and neurochemical changes. However, results from animal studies are often inconsistent. To better understand the characteristics of the model and effects of d-galactose on neurobehavioral and neurochemical outcomes in rodents we performed a systematic review and meta-analysis. We applied random-effects meta-analysis to evaluate the effect of study features. Our results give an overview of the characteristics of the dgalactose rodent ageing model, including neurobehavioral and neurochemical outcomes. We found that few studies took measures to reduce risks of bias, and substantial heterogeneity in the reported effects of d-galactose in included studies. This highlights the need for improvements in the use of the d-galactose rodent ageing model if it is to provide useful in the development of drugs to treat human ageing.

show abstract

Section: Introductionmentioning

confidence: 99%

D-galactose-induced brain ageing model: A systematic review and meta-analysis on cognitive outcomes and oxidative stress indices

et al. 2017

View full text Add to dashboard Cite

show abstract

“…Compared with healthy animals, animals chronically treated with d -gal display shortened life span, cognitive dysfunction, neurodegeneration, and impaired immune responses, which resembles natural aging 22,23. Recently, studies focused on the roles of galactose in cellular senescence have shown that the mechanisms underlying d -gal -induced aging likely involve glucose and 1ipid metabolic disorders, increased oxidative damage, the accumulation of advanced glycation end products, impaired elimination of abnormal substances, accelerated cell apoptosis, and enhanced insulin resistance 22,24.…”

Section: Discussionmentioning

confidence: 99%

Acute kidney injury and inflammatory response of sepsis following cecal ligation and puncture in D-galactose-induced aging rats

Liu¹,

Hu²,

Mao³

et al. 2017

CIA

View full text Add to dashboard Cite

BackgroundRecently, the d-galactose (d-gal)-induced mimetic aging rat model has been widely used in studies of age-associated diseases, which have shown that chronic d-gal exposure induces premature aging similar to natural aging in rats. With the increasing rate of sepsis in the geriatric population, an easy-access animal model for preclinical studies of elderly sepsis is urgently needed. This study investigates whether a sepsis model that is established in d-gal-induced aging rats can serve as a suitable model for preclinical studies of elderly patients with sepsis.ObjectiveTo investigate the acute kidney injury (AKI) and inflammatory response of sepsis following cecal ligation and puncture (CLP) in d-gal-induced aging rats.MethodsTwelve-week-old male Sprague Dawley rats were divided into low-dose d-gal (L d-gal, 125 mg/kg/d), high-dose d-gal (H d-gal, 500 mg/kg/d), and control groups. After daily subcutaneous injection of d-gal for 6 weeks, the CLP method was used to establish a sepsis model.ResultsThe mortality was 73.3%, 40%, and 33.3% in the H d-gal, L d-gal, and control groups, respectively. Blood urea nitrogen, creatinine, plasma neutrophil gelatinase-associated lipocalin, interleukin-6, interleukin-10, and tumor necrosis factor-α were markedly increased in the H d-gal group after establishment of the sepsis model (H d-gal vs control, P<0.05 at 12 h and 24 h post-CLP). The rate of severe AKI (RIFLE-F) at 24 h post-CLP was 43% for both the control and L d-gal groups and 80% for the H d-gal group.ConclusionHigh-dose- d-gal-induced aging rats are more likely to die from sepsis than are young rats, and probably this is associated with increased severity of septic AKI and an increased inflammatory response. Therefore, use of the high-dose- d-gal-induced aging rat model of sepsis for preclinical studies can provide more useful information for the treatment of sepsis in elderly patients.

show abstract

“…In vivo assessment of the effects of Porphyra yezoensis enzyme degradation extract on D-galactose-treated mice Animals and experimental design. Female ICR mice (27,28) (18-20 g) at 3 weeks of age were purchased from Vital River Laboratory Animal Centre (Beijing, China; Licensed ID: SCXK2012-0001). Animals were kept in a polyacrylic cage and maintained under constant conditions (room temperature 23 ± 1°C and humidity 50 ± 10 %) with alternative 12 h light-12 h dark cycles.…”

Section: Sample Preparation and Composition Analysismentioning

confidence: 99%

Protective effects of enzyme degradation extract from Porphyra yezoensis against oxidative stress and brain injury in d-galactose-induced ageing mice

Wang¹,

Shen²,

Yu³

et al. 2019

Br J Nutr

View full text Add to dashboard Cite

The present study investigated the effects of Porphyra yezoensis enzyme degradation extract (PYEDE) on the brain injuries and neurodegenerative diseases due to oxidative stress. We used in vitro antioxidant systems to verify the antioxidant potential of PYEDE. The results indicated that the PYEDE alleviated weight loss and organ atrophy, reduced the levels of lipid peroxidation and protein carbonylation and elevated reduced glutathione (GSH) content in the serum and brains of the d-galactose-induced ageing model mice. The PYEDE also renewed the glutathione peroxidase (GSH-Px), superoxide dismutase and total antioxidant capability activities, down-regulated the inducible nitric oxide synthase activity and nitric oxide levels, normalised the hippocampal neurons and modulated multiple neurotransmitter systems by inhibiting the activities of acetylcholinesterase and monoamine oxidase in the up-regulation of acetylcholine, dopamine and noradrenaline levels. Overall, the PYEDE is a promising supplement for the alleviation of oxidative stress and age-associated brain diseases.

show abstract

Mussel oligopeptides ameliorate cognition deficit and attenuate brain senescence in d-galactose-induced aging mice

Cited by 41 publications

References 49 publications

D-galactose-induced brain ageing model: A systematic review and meta-analysis on cognitive outcomes and oxidative stress indices

D-galactose-induced brain ageing model: A systematic review and meta-analysis on cognitive outcomes and oxidative stress indices

Acute kidney injury and inflammatory response of sepsis following cecal ligation and puncture in D-galactose-induced aging rats

Protective effects of enzyme degradation extract from Porphyra yezoensis against oxidative stress and brain injury in d-galactose-induced ageing mice

Contact Info

Product

Resources

About