Mussel patterned with 4D biodegrading elastomer durably recruits regenerative macrophages to promote regeneration of craniofacial bone

Liu, Xuzheng; Chen, Wan-Li; Shao, Bo; Zhang, Xinchi; Wang, Yinggang; Zhang, Siqian; Wu, Wei

doi:10.1016/j.biomaterials.2021.120998

Cited by 62 publications

(69 citation statements)

References 62 publications

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“…1, L and M). As described in our previous study ( 29 ), the potential of further shape morphing (the straight tube was morphed into the “S” shape) also met the variant anatomic requirements in humans (Fig. 1N).…”

Section: Resultssupporting

confidence: 60%

Recombinant DTβ4-inspired porous 3D vascular graft enhanced antithrombogenicity and recruited circulating CD93 ⁺ /CD34 ⁺ cells for endothelialization

et al. 2022

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Matching material degradation with host remodeling, including endothelialization and muscular remodeling, is important to vascular regeneration. We fabricated 3D PGS-PCL vascular grafts, which presented tunable polymer components, porosity, mechanical strength, and degrading rate. Furthermore, highly porous structures enabled 3D patterning of conjugated heparin-binding peptide, dimeric thymosin β4 (DTβ4), which played key roles in antiplatelets, fibrinogenesis inhibition, and recruiting circulating progenitor cells, thereafter contributed to high patency rate, and unprecedentedly acquired carotid arterial regeneration in rabbit model. Through single-cell RNA sequencing analysis and cell tracing studies, a subset of endothelial progenitor cells, myeloid-derived CD93 + /CD34 + cells, was identified as the main contributor to final endothelium regeneration. To conclude, DTβ4-inspired porous 3DVGs present adjustable physical properties, superior anticoagulating, and re-endothelializing potentials, which leads to the regeneration of small-caliber artery, thus offering a promising tool for vessel replacement in clinical applications.

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Section: Resultssupporting

confidence: 60%

Recombinant DTβ4-inspired porous 3D vascular graft enhanced antithrombogenicity and recruited circulating CD93 ⁺ /CD34 ⁺ cells for endothelialization

et al. 2022

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“…Bone marrow derived monocytes were obtained from the freshly isolated bone marrow of the femur and tibia of 2 weeks old SD rats. The monocytes were isolated using the differential adhesion method as previously reported [ 32 , 33 ]. Macrophages were differentiated from bone marrow derived monocytes in the presence of macrophage colony stimulating factor (M-CSF, Peprotech) and then seeded on the PBS, Rapa, and 3-MA loaded scaffolds.…”

Section: Methodsmentioning

confidence: 99%

Pharmacological manipulation of macrophage autophagy effectively rejuvenates the regenerative potential of biodegrading vascular graft in aging body

Chen

Xiao

Liu

et al. 2022

Bioactive Materials

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Declined regenerative potential and aggravated inflammation upon aging create an inappropriate environment for arterial regeneration. Macrophages are one of vital effector cells in the immune microenvironment, especially during biomaterials mediated repairing process. Here, we revealed that the macrophage autophagy decreased with aging, which led to aggravated inflammation, thereby causing poor vascular remodeling of artificial grafts in aging body. Through loading the autophagy-targeted drugs, rapamycin and 3-MA (3-methyladenine), in PCL (polycaprolactone) sheath of the PGS (poly glycerol sebacate) - PCL vascular graft, the essential role of macrophage autophagy was confirmed in regulating macrophage polarization and biomaterial degradation. Moreover, the utilization of rapamycin promoted anti-inflammatory polarization of macrophage by activating autophagy, which further promoted myogenic differentiation of vascular progenitor cells and accelerated endothelialization. Our study elucidated the contribution of pharmacological manipulation of macrophage autophagy in promoting regeneration of small caliber artery, which may pave a new avenue for clinical translation of vascular grafts in aging body.

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“…Poly(glycerol sebacate) (PGS) is a polyester synthesized from glycerin-3 and sebacic acid-2 that has received considerable attention in tissue-engineering applications [ 80 ]. PGS was modified by 3D-printing technology with nano-HA [ 32 ], PEG/TCP [ 81 ], PHB [ 82 ], PCL [ 83 , 84 ], poly(vinyl alcohol) (PVA) [ 85 ], and poly(acrylic acid) (PAA) [ 86 ] to obtain potential scaffolds for reconstruction of bone tissue, especially craniofacial bone. Among the characteristics of an ideal polyester for bone regeneration, there is increasing interest in the development of novel materials with antibacterial properties [ 87 ].…”

Section: Orthopedic Applicationsmentioning

confidence: 99%

Special Features of Polyester-Based Materials for Medical Applications

Darie-Niță¹,

Râpă

Frąckowiak

2022

Polymers

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This article presents current possibilities of using polyester-based materials in hard and soft tissue engineering, wound dressings, surgical implants, vascular reconstructive surgery, ophthalmology, and other medical applications. The review summarizes the recent literature on the key features of processing methods and potential suitable combinations of polyester-based materials with improved physicochemical and biological properties that meet the specific requirements for selected medical fields. The polyester materials used in multiresistant infection prevention, including during the COVID-19 pandemic, as well as aspects covering environmental concerns, current risks and limitations, and potential future directions are also addressed. Depending on the different features of polyester types, as well as their specific medical applications, it can be generally estimated that 25–50% polyesters are used in the medical field, while an increase of at least 20% has been achieved since the COVID-19 pandemic started. The remaining percentage is provided by other types of natural or synthetic polymers; i.e., 25% polyolefins in personal protection equipment (PPE).

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Mussel patterned with 4D biodegrading elastomer durably recruits regenerative macrophages to promote regeneration of craniofacial bone

Cited by 62 publications

References 62 publications

Recombinant DTβ4-inspired porous 3D vascular graft enhanced antithrombogenicity and recruited circulating CD93 ⁺ /CD34 ⁺ cells for endothelialization

Recombinant DTβ4-inspired porous 3D vascular graft enhanced antithrombogenicity and recruited circulating CD93 ⁺ /CD34 ⁺ cells for endothelialization

Pharmacological manipulation of macrophage autophagy effectively rejuvenates the regenerative potential of biodegrading vascular graft in aging body

Special Features of Polyester-Based Materials for Medical Applications

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Mussel patterned with 4D biodegrading elastomer durably recruits regenerative macrophages to promote regeneration of craniofacial bone

Cited by 62 publications

References 62 publications

Recombinant DTβ4-inspired porous 3D vascular graft enhanced antithrombogenicity and recruited circulating CD93 + /CD34 + cells for endothelialization

Recombinant DTβ4-inspired porous 3D vascular graft enhanced antithrombogenicity and recruited circulating CD93 + /CD34 + cells for endothelialization

Pharmacological manipulation of macrophage autophagy effectively rejuvenates the regenerative potential of biodegrading vascular graft in aging body

Special Features of Polyester-Based Materials for Medical Applications

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Product

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About

Recombinant DTβ4-inspired porous 3D vascular graft enhanced antithrombogenicity and recruited circulating CD93 ⁺ /CD34 ⁺ cells for endothelialization

Recombinant DTβ4-inspired porous 3D vascular graft enhanced antithrombogenicity and recruited circulating CD93 ⁺ /CD34 ⁺ cells for endothelialization